Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro

Life Sciences

Volumn 78, Issue 9, 2006, Pages 950-957

  Sekiguchi, Fumiko ^a   Hasegawa, Naomi ^a   Inoshita, Keiko ^a   Yonezawa, Daiki ^a   Inoi, Naoki ^a   Kanke, Toru ^b   Saito, Naohiro ^b   Kawabata, Atsufumi ^a  

^a KINKI UNIVERSITY   (Japan)

^b KOWA COMPANY LTD   (Japan)

Author keywords

Apamin; Capsaicin; Contraction; Gastrointestinal smooth muscle; Indomethacin; Intestine; PAR 2 knockout mouse; Proteinase (protease) activated receptor (PAR); Relaxation; Stomach

Indexed keywords

APAMIN; CAPSAICIN; INDOMETACIN; POTASSIUM CHANNEL BLOCKING AGENT; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GASTROINTESTINAL MOTILITY; IN VITRO STUDY; INTESTINE CONTRACTION; INTESTINE MUSCLE; MOUSE; NONHUMAN; SMOOTH MUSCLE RELAXATION; STOMACH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APAMIN; CALCIUM CHANNEL BLOCKERS; CAPSAICIN; FEMALE; GASTROINTESTINAL MOTILITY; INDOMETHACIN; INTESTINES; ISOMETRIC CONTRACTION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE RELAXATION; NEURONS, AFFERENT; OLIGOPEPTIDES; POTASSIUM CHANNELS; PROSTAGLANDINS; RECEPTOR, PAR-1; RECEPTOR, PAR-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH;

ANIMALIA;

EID: 30944449423     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.06.035     Document Type: Article

References (46)

1. G. Cirino, C. Cicala, M.R. Bucci, L. Sorrentino, J.M. Maraganore, and S.R. Stone Thrombin functions as an inflammatory mediator through activation of its receptor Journal of Experimental Medicine 183 3 1996 821 827
2. T.M. Cocks, B. Fong, J.M. Chow, G.P. Anderson, A.G. Frauman, R.G. Goldie, P.J. Henry, M.J. Carr, J.R. Hamilton, and J.D. Moffatt A protective role for protease-activated receptors in the airways Nature 398 6723 1999 156 160
3. T.M. Cocks, V. Sozzi, J.D. Moffatt, and S. Selemidis Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle Gastroenterology 116 3 1999 586 592
4. L. de Garavilla, N. Vergnolle, S.H. Young, H. Ennes, M. Steinhoff, V.S. Ossovskaya, M.R. D'Andrea, E.A. Mayer, J.L. Wallace, M.D. Hollenberg, P. Andrade-Gordon, and N.W. Bunnett Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism British Journal of Pharmacology 133 7 2001 975 987
5. W.R. Ferrell, J.C. Lockhart, E.B. Kelso, L. Dunning, R. Plevin, S.E. Meek, A.J. Smith, G.D. Hunter, J.S. McLean, F. McGarry, R. Ramage, L. Jiang, T. Kanke, and J. Kawagoe Essential role for proteinase-activated receptor-2 in arthritis Journal of Clinical Investigation 111 1 2003 35 41
6. C. Gao, S. Liu, H.Z. Hu, N. Gao, G.Y. Kim, Y. Xia, and J.D. Wood Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine Gastroenterology 123 5 2002 1554 1564
7. Y. Gui, R. Loutzenhiser, and M.D. Hollenberg Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney American Journal of Physiology. Renal Physiology 285 1 2003 F95 F104
8. J.R. Hamilton, and T.M. Cocks Heterogeneous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary artery British Journal of Pharmacology 130 1 2000 181 188
9. M.D. Hollenberg, A.A. Laniyonu, M. Saifeddine, and G.J. Moore Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: evidence for receptor subtypes Molecular Pharmacology 43 6 1993 921 930
10. H. Ishihara, A.J. Connolly, D. Zeng, M.L. Kahn, Y.W. Zheng, C. Timmons, T. Tram, and S.R. Coughlin Protease-activated receptor 3 is a second thrombin receptor in humans Nature 386 6624 1997 502 506
11. M.L. Kahn, Y.W. Zheng, W. Huang, V. Bigornia, D. Zeng, S. Moff, R.V. Farese Jr., C. Tam, and S.R. Coughlin A dual thrombin receptor system for platelet activation Nature 394 6694 1998 690 694
12. A. Kawabata PAR-2: structure, function and relevance to human diseases of the gastric mucosa Expert Reviews in Molecular Medicine 2002 2002 1 17 (http://www.expertreviews.org/02004799h.htm )
13. A. Kawabata Gastrointestinal functions of proteinase-activated receptors Life Sciences 74 2-3 2003 247 254
14. A. Kawabata, R. Kuroda, H. Nishikawa, T. Asai, K. Kataoka, and M. Taneda Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide British Journal of Pharmacology 126 8 1999 1856 1862
15. A. Kawabata, R. Kuroda, H. Nishikawa, and K. Kawai Modulation by protease-activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation British Journal of Pharmacology 128 4 1999 865 872
16. A. Kawabata, R. Kuroda, N. Kuroki, H. Nishikawa, K. Kawai, and H. Araki Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle Life Sciences 67 20 2000 2521 2530
17. A. Kawabata, H. Nishikawa, R. Kuroda, K. Kawai, and M.D. Hollenberg Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice British Journal of Pharmacology 129 8 2000 1808 1814
18. A. Kawabata, N. Kawao, R. Kuroda, A. Tanaka, H. Itoh, and H. Nishikawa Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats NeuroReport 12 4 2001 715 719
19. A. Kawabata, M. Kinoshita, H. Nishikawa, R. Kuroda, M. Nishida, H. Araki, N. Arizono, Y. Oda, and K. Kakehi The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection Journal of Clinical Investigation 107 11 2001 1443 1450
20. A. Kawabata, R. Kuroda, N. Nagata, N. Kawao, T. Masuko, H. Nishikawa, and K. Kawai In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse British Journal of Pharmacology 133 8 2001 1213 1218
21. A. Kawabata, N. Kawao, H. Itoh, C. Shimada, K. Takebe, R. Kuroda, T. Masuko, K. Kataoka, and S. Ogawa Role of N-methyl-d-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats Neuroscience Letters 329 3 2002 349 353
22. A. Kawabata, S. Kubo, T. Ishiki, N. Kawao, F. Sekiguchi, R. Kuroda, M.D. Hollenberg, T. Kanke, and N. Saito Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity Journal of Pharmacology and Experimental Therapeutics 311 1 2004 402 410
23. A. Kawabata, S. Kubo, Y. Nakaya, T. Ishiki, R. Kuroda, F. Sekiguchi, N. Kawao, and H. Nishikawa Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery Cardiovascular Research 61 4 2004 683 692
24. A. Kawabata, H. Nishikawa, H. Saitoh, Y. Nakaya, K. Hiramatsu, S. Kubo, M. Nishida, N. Kawao, R. Kuroda, F. Sekiguchi, M. Kinoshita, K. Kakehi, N. Arizono, H. Yamagishi, and K. Kawai A protective role of protease-activated receptor 1 in rat gastric mucosa Gastroenterology 126 1 2004 208 219
25. N. Kawao, Y. Sakaguchi, A. Tagome, R. Kuroda, S. Nishida, K. Irimajiri, H. Nishikawa, K. Kawai, M.D. Hollenberg, and A. Kawabata Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion British Journal of Pharmacology 135 5 2002 1292 1296
26. N. Kawao, H. Ikeda, T. Kitano, R. Kuroda, F. Sekiguchi, K. Kataoka, Y. Kamanaka, and A. Kawabata Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2 Journal of Pharmacological Sciences 94 3 2004 277 285
27. S.R. Macfarlane, M.J. Seatter, T. Kanke, G.D. Hunter, and R. Plevin Proteinase-activated receptors Pharmacological Reviews 53 2 2001 245 282
28. F. Mule, M.C. Baffi, and M.C. Cerra Dual effect mediated by protease-activated receptors on the mechanical activity of rat colon British Journal of Pharmacology 136 3 2002 367 374
29. F. Mule, M.C. Baffi, M. Falzone, and M.C. Cerra Signal transduction pathways involved in the mechanical responses to protease-activated receptors in rat colon Journal of Pharmacology and Experimental Therapeutics 303 3 2002 1265 1272
30. F. Mule, M.C. Baffi, A. Capparelli, and R. Pizzuti Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle British Journal of Pharmacology 139 3 2003 598 604
31. F. Mule, R. Pizzuti, A. Capparelli, and N. Vergnolle Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon Gut 53 2 2004 229 234
32. H. Nishikawa, K. Kawai, S. Nishimura, S. Tanaka, H. Araki, B. Al-Ani, M.D. Hollenberg, R. Kuroda, and A. Kawabata Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats European Journal of Pharmacology 447 1 2002 87 90
33. H. Nishikawa, K. Kawai, M. Tanaka, H. Ohtani, S. Tanaka, C. Kitagawa, M. Nishida, T. Abe, H. Araki, and A. Kawabata Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms Journal of Pharmacology and Experimental Therapeutics 312 1 2005 324 331
34. S. Nystedt, K. Emilsson, C. Wahlestedt, and J. Sundelin Molecular cloning of a potential proteinase activated receptor Proceedings of the National Academy of Sciences of the United States of America 91 20 1994 9208 9212
35. V.S. Ossovskaya, and N.W. Bunnett Protease-activated receptors: contribution to physiology and disease Physiological Reviews 84 2 2004 579 621
36. F.L. Ricciardolo, M. Steinhoff, S. Amadesi, R. Guerrini, M. Tognetto, M. Trevisani, C. Creminon, C. Bertrand, N.W. Bunnett, L.M. Fabbri, S. Salvadori, and P. Geppetti Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways American Journal of Respiratory and Critical Care Medicine 161 5 2000 1672 1680
37. M. Saifeddine, B. al-Ani, C.H. Cheng, L. Wang, and M.D. Hollenberg Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue British Journal of Pharmacology 118 3 1996 521 530
38. F. Sekiguchi, and A. Kawabata Protease-activated receptors (PARs) as therapeutic targets: development of agonists/antagonists and modulation of gastrointestinal functions Drug Design Reviews-Online 1 4 2004 287 296
39. C.G. Sobey, J.D. Moffatt, and T.M. Cocks Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation Stroke 30 9 1999 1933 1940 (discussion 1941)
40. M. Steinhoff, N. Vergnolle, S.H. Young, M. Tognetto, S. Amadesi, H.S. Ennes, M. Trevisani, M.D. Hollenberg, J.L. Wallace, G.H. Caughey, S.E. Mitchell, L.M. Williams, P. Geppetti, E.A. Mayer, and N.W. Bunnett Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism Nature Medicine 6 2 2000 151 158
41. N. Vergnolle Modulation of visceral pain and inflammation by protease-activated receptors British Journal of Pharmacology 141 8 2004 1264 1274
42. N. Vergnolle, N.W. Bunnett, K.A. Sharkey, V. Brussee, S.J. Compton, E.F. Grady, G. Cirino, N. Gerard, A.I. Basbaum, P. Andrade-Gordon, M.D. Hollenberg, and J.L. Wallace Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway Nature Medicine 7 7 2001 821 826
43. N. Vergnolle, C.K. Derian, M.R. D'Andrea, M. Steinhoff, and P. Andrade-Gordon Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4 Journal of Immunology 169 3 2002 1467 1473
44. T.K. Vu, D.T. Hung, V.I. Wheaton, and S.R. Coughlin Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Cell 64 6 1991 1057 1068
45. W.F. Xu, H. Andersen, T.E. Whitmore, S.R. Presnell, D.P. Yee, A. Ching, T. Gilbert, E.W. Davie, and D.C. Foster Cloning and characterization of human protease-activated receptor 4 Proceedings of the National Academy of Sciences of the United States of America 95 12 1998 6642 6646
46. A. Zhao, and T. Shea-Donohue PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors American Journal of Physiology: Gastrointestinal and Liver Physiology 285 4 2003 G696 G703