Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel

Nuclear Medicine and Biology

Volumn 35, Issue 2, 2008, Pages 203-212

  Fuchigami, Takeshi ^a,c   Haradahira, Terushi ^b   Fujimoto, Noriko ^a   Okauchi, Takashi ^b   Maeda, Jun ^b   Suzuki, Kazutoshi ^b   Suhara, Tetsuya ^b   Yamamoto, Fumihiko ^a   Sasaki, Shigeki ^a   Mukai, Takahiro ^a   Yamaguchi, Hiroshi ^c   Ogawa, Mikako ^c   Magata, Yasuhiro ^c   Maeda, Minoru ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

4 hydroxy 2(1H) quinolone; Agonist sensitivity; Glycine site antagonist; PET

Indexed keywords

4 HYDROXY 3 (3 METHOXYPHENYL) 2(1H)QUINOLONE C 11; 5 ETHYL 4 HYDROXY 3 (3 METHOXYPHENYL) 2(1H)QUINOLONE C 11; 5 IODO 4 HYDROXY 3 (3 METHOXYPHENYL) 2(1H)QUINOLONE C 11; 7 CHLORO 4 HYDROXY 3 [3 (4 METHOXYBENZYL)PHENYL] 2 QUINOLONE; 7 CHLORO 4 HYDROXY 3 [3 (4 METHOXYBENZYL)PHENYL] 2 QUINOLONE C 11; AMINO ACID RECEPTOR AFFECTING AGENT; GLYCINE; GLYCINE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; QUINOLONE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG UPTAKE; FOREBRAIN; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT;

ANIMALS; ANTICOAGULANTS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; GLYCINE; HYDROXYQUINOLINES; ION CHANNELS; MICE; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RECEPTORS, N-METHYL-D-ASPARTATE; TISSUE DISTRIBUTION; WARFARIN;

EID: 38849086644     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.10.007     Document Type: Article

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