Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro- 3-[3-(4-[11C] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography

Synapse

Volumn 61, Issue 10, 2007, Pages 795-800

  Matsumoto, Ryohei ^a,b   Haradahira, Terushi ^a   Ito, Hiroshi ^a   Fujimura, Yota ^a   Seki, Chie ^a   Ikoma, Yoko ^a   Maeda, Jun ^a   Arakawa, Ryosuke ^a   Takano, Akihiro ^a   Takahashi, Hidehiko ^a   Higuchi, Makoto ^a   Suzuki, Kazutoshi ^a   Fukui, Kenji ^b   Suhara, Tetsuya ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

D serine; Glycine site; Human brain; N methyl D aspartate (NMDA) receptors; NR2C subunit; PET

Indexed keywords

4 ACETOXY 7 CHLORO 3 [3 (4 METHOXYBENZYL C 11) PHENYL] 2(1H) QUINOLINE; 7 CHLORO 4 HYDROXY 3 [3 (4 METHOXYBENZYL)PHENYL] 2 QUINOLONE; CARBON 11; CYCLOSPORIN; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUINOLINE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN; CEREBELLUM CORTEX; CONTROLLED STUDY; DATA ANALYSIS; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; MALE; MEASUREMENT; NONHUMAN; NORMAL HUMAN; PERMEABILITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RAT; WHITE MATTER;

ADULT; ANIMALS; BINDING SITES; BRAIN; BUTYRIC ACIDS; CYCLOSPORINS; DRUG INTERACTIONS; ENZYME INHIBITORS; FEASIBILITY STUDIES; GLYCINE; HUMANS; HYDROXYQUINOLINES; MALE; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDINONES; QUINOLONES; RADIOPHARMACEUTICALS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; TISSUE DISTRIBUTION;

EID: 34548245979     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20415     Document Type: Article

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