A strategy for increasing the brain uptake of a radioligand in animals: Use of a drug that inhibits plasma protein binding

Journal of Inorganic Biochemistry

Volumn 78, Issue 3, 2000, Pages 357-360

  Haradahira, T ^a   Zhang, M R ^a   Maeda, J ^a   Okauchi, T ^a   Kawabe, K ^a   Kida, T ^a   Suzuki, K ^a   Suhara, T ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Carbon 11; Competitive inhibition; L 703,717; Plasma protein binding; Warfarin

Indexed keywords

7 CHLORO 4 HYDROXY 3 [3 (4 METHOXYBENZYL)PHENYL] 2 QUINOLONE; CARBON 11; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENOLSULFONPHTHALEIN; RADIOLIGAND; SALICYLIC ACID; SERUM ALBUMIN; TRYPTOPHAN; WARFARIN; CARBON; DIAGNOSTIC AGENT; PLASMA PROTEIN; QUINOLINOL DERIVATIVE; QUINOLONE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD BRAIN BARRIER; COMPETITIVE INHIBITION; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG UPTAKE; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; POSITRON; ANIMAL; BRAIN; MALE; METABOLISM; PROTEIN BINDING; RAT; SPRAGUE DAWLEY RAT;

ANIMALIA; RODENTIA;

ANIMALS; BLOOD PROTEINS; BRAIN; CARBON RADIOISOTOPES; HYDROXYQUINOLINES; MALE; MICE; PROTEIN BINDING; QUINOLONES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; WARFARIN;

EID: 0034182879     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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