A positron-emitter labeled glycineB site antagonist, [11C]L-703,717, preferentially binds to a cerebellar NMDA receptor subtype consisting of GluR ε3 subunit in vivo, but not in vitro

Synapse

Volumn 43, Issue 2, 2002, Pages 131-133

  Haradahira, Terushi ^a,e   Okauchi, Takashi ^a   Maeda, Jun ^a,b   Zhang, Ming Rong ^c   Kida, Takayo ^a,d   Kawabe, Kouichi ^a,e   Mishina, Masayoshi ^a   Watanabe, Yasuyoshi ^d   Suzuki, Kazutoshi ^e   Suhara, Tetsuya ^a,b  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b 141 0032   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

GluR 3 subunit selective; Glycine site; L 703,717; NMDA receptor; PET tracer

Indexed keywords

7 CHLORO 4 HYDROXY 3 [3 (4 METHOXYBENZYL)PHENYL] 2 QUINOLONE; CARBON 11; GLUTAMATE RECEPTOR; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BRAIN CORTEX; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY;

ANIMALS; BINDING, COMPETITIVE; CARBON RADIOISOTOPES; CEREBELLUM; ELECTRONS; GLYCINE; HYDROXYQUINOLINES; MICE; MICE, KNOCKOUT; NEURONS; QUINOLONES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0036140152     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10029     Document Type: Article

References (10)

1. 3H]strychnine binding sites in rat brain
2. Glycine and N-methyl-D-aspartate receptors: Physiological significance and possible therapeutic applications
3. A strategy for increasing the brain uptake of a radioligand in animals: Use of a drug that inhibits plasma protein binding
4. A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeled analog
5. 11C]L-703,717
6. Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase
7. Differentiation of glycine antagonist site of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors
8. Structure and function of the NMDA receptor channel
9. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
10. 11C]methyl-4-Pipendylbenzylate