Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: Evidence for two pharmacological classes of antagonists

British Journal of Pharmacology

Volumn 130, Issue 1, 2000, Pages 65-72

  Chopra, Bela ^a   Chazot, Paul L ^a,b   Stephenson, F Anne ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Glycine site antagonists; Ionotropic glutamate receptors; MDL105,519; NMDA receptor; Radioligand binding; Strychnine insensitive glycine sites

Indexed keywords

3 (2 CARBOXY 2 PHENYLETHENYL) 4,6 DICHLORO 1H INDOLE 2 CARBOXYLIC ACID; 4 [2 (4 AZIDOPHENYL) ACETYLAMINO] 5,7 DICHLORO 1,2,3,4 TETRAHYDROQUINOLINE 2 CARBOXYLIC ACID; 4 [2 (4 AZIDOPHENYL)ACETYLAMINO] 5,7 DICHLORO 1,2,3,4 TETRAHYDRO 2 QUINOLINECARBOXYLIC ACID; 4,6 DICHLORO 3 (2 OXO 1 PHENYL 3 PYRROLIDINYLIDENEMETHYL) 1H INDOLE 2 CARBOXYLIC ACID; 5,7 DICHLORO 1,2,3,4 TETRAHYDRO 4 (3 PHENYLUREIDO) 2 QUINOLINECARBOXYLIC ACID; 5,7 DICHLOROKYNURENIC ACID; 7 CHLORO 4 HYDROXY 3 (3 PHENOXYPHENYL) 2 QUINOLONE; AMINO ACID RECEPTOR BLOCKING AGENT; GAVESTINEL; GLYCINE; GLYCINE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOLECULAR MODEL; PRIORITY JOURNAL;

EID: 0034058131     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703298     Document Type: Article

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