The effect of water solubility of solutes on their flux through human skin in vitro: A prodrug database integrated into the extended Flynn database

International Journal of Pharmaceutics

Volumn 351, Issue 1-2, 2008, Pages 92-103

  Juntunen, Juha ^a,b   Majumdar, Susruta ^c   Sloan, Kenneth B ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Hydrolysis; Octanol solubility; Prodrugs; Roberts Sloan equation; Water solubility

Indexed keywords

ACETYLSALICYLIC ACID; CARBAMAZEPINE; CYCLIZINE; ESTER DERIVATIVE; FLURBIPROFEN; IBUPROFEN; KETOPROFEN; MORPHINE; NALIDIXIC ACID; NAPROXEN; OCTANOL; PHENOL DERIVATIVE; PRODRUG; WATER;

ARTICLE; DATA BASE; DRUG SOLUBILITY; HUMAN; HUMAN TISSUE; HYDROLYSIS; MOLECULAR WEIGHT; PRIORITY JOURNAL; SKIN; SKINFOLD THICKNESS; SOLUBILITY; SOLUTE;

1-OCTANOL; DATABASES, FACTUAL; HUMANS; MOLECULAR WEIGHT; PERMEABILITY; PRODRUGS; SKIN; SKIN ABSORPTION; SOLUBILITY; SOLVENTS; WATER;

EID: 38749089065     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.09.034     Document Type: Article

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