Control of sulfatase and sulfotransferase activities by medrogestone in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines

Journal of Steroid Biochemistry and Molecular Biology

Volumn 70, Issue 1-3, 1999, Pages 39-45

  Chetrite, Gérard S ^a   Ebert, Christa ^b   Wright, Françoise ^c   Philippe, A C ^d   Pasqualini, Jorge R ^a  

^a Hormones and Cancer Research Unit   (France)

^b Solvay Pharmaceuticals GmbH   (Germany)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d Institut de Puericulture   (France)

Author keywords

Breast cancer; MCF 7 and T 47D cell lines; Medrogestone; Progestins; Sulfatase; Sulfotransferase

Indexed keywords

MEDROGESTONE; SULFATASE; SULFOTRANSFERASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; PROTEIN SYNTHESIS;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTRONE; FEMALE; HUMANS; MEDROGESTONE; PROGESTERONE CONGENERS; SULFATASES; SULFOTRANSFERASES; TUMOR CELLS, CULTURED;

EID: 0032865412     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(99)00095-3     Document Type: Article

References (49)

1. Segaloff A. Hormones and mammary carcinogenesis. McGuire W.L. Breast Cancer 2: Advances in Research and Treatment: Experimental Biology. 1978;1-22 Plenum, New York.
2. Henderson B.E., Ross R., Bernstein L. Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res. 48:1988;246-253.
3. Kirschner M.A. The role of hormones in the development of human breast cancer. McGuire W.L. Cancer 3: Advances in Research and Treatment: Current Topics. 1979;199-226 Plenum, New York.
4. Pasqualini J.R., Cortes-Prieto J., Chetrite G., Talbi M., Ruiz A. Concentrations of estrone, estradiol and their sulfates and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. Int. J. Cancer. 70:1997;639-643.
5. van Landeghem A.A.J., Poortman J., Nabuurs M., Thijssen J.H.H. Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res. 45:1985;2900-2906.
6. Pasqualini J.R., Chetrite G., Blacker C., Feinstein M.C., Delalonde L., Talbi M., Maloche C. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer. J. Clin. Endocr. Metab. 81:1996;1460-1464.
7. Vermeulen A., Deslypere J.P., Paridaens R., Leclercq G., Roy F., Heuson J.C. Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur. J. Cancer Clin. Oncol. 22:1986;515-525.
8. Pasqualini J.R., Gelly C., Nguyen B.-L., Vella C. Importance of estrogen sulfates in breast cancer. J. Steroid Biochem. 34:1989;155-163.
9. 3H-oestradiol by normal breast and breast tumour tissues in post-menopausal women. Int. J. Cancer. 38:1986;193-196.
10. Pasqualini J.R., Chetrite G. Activity, regulation and expression of sulfatase, sulfotransferase and 17β-hydroxysteroid dehydrogenase in breast cancer. Pasqualini J.R., Katzenellenbogen B.S. Hormone-dependent Cancer. 1996;25-80 Marcel Dekker, New York.
11. Raju U., Blaustein A., Levitz M. Conjugation of androgens and estrogens by human breast tumors in vitro. Steroids. 35:1980;685-695.
12. Lipton A., Santner S.J., Santen R.J., Harvey H.A., Feil P.D., White-Hershey D., Bartholomew M.J., Antle C.E. Aromatase activity in primary and metastatic human breast cancer. Cancer. 59:1987;779-782.
13. Silva M.C., Rowlands M.G., Dowsett M., Gusterson B., McKinna J.A., Fryatt I., Coombes R.C. Intratumoral aromatase as a prognostic factor in human breast carcinoma. Cancer Res. 490:1989;2588-2591.
14. Dao T.L., Hayes C., Libby P.R. Steroid sulfatase activities in human breast tumors. Proc. Soc. Exp. Biol. Med. 146:1974;381-384.
15. Vignon F., Terqui M., Westley B., Derocq D., Rochefort H. Effects of plasma estrogen sulfates in mammary cancer cells. Endocrinology. 106:1980;1079-1086.
16. Pasqualini J.R., Gelly C., Lecerf F. Estrogen sulfates: biological and ultrastructural responses and metabolism in MCF-7 human breast cancer cells. Breast Cancer Res. Treat. 8:1986;233-240.
17. Pasqualini J.R., Schatz B., Varin C., Nguyen B-L. Recent data on estrogen sulfatases and sulfotransferases activities in human breast cancer. J. Steroid Biochem. Molec. Biol. 41:1992;323-329.
18. MacIndoe J.H. The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells. Endocrinology. 123:1988;1281-1287.
19. Labrie F., Luu-The V., Lin S.-X., Labrie C., Simard J., Breton R., Bélanger A. The key role of 17β-hydroxysteroid dehydrogenase in sex steroid biology. Steroids. 62:1997;148-158.
20. Abul-Hajj Y.J. Relationship between estrogen receptors, 17β-hydroxysteroid dehydrogenase and estrogen content in human breast cancer. Steroids. 34:1979;217-225.
21. Nguyen B.L., Chetrite G., Pasqualini J.R. Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Breast Cancer Res. Treat. 34:1995;139-146.
22. Santner S.J., Feil P.D., Santen R.J. In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. J. Clin. Endocr. Metab. 59:1984;29-33.
23. Santner S.J., Ohlsson-Wilhelm B., Santen R.J. Estrone sulfate promotes human breast cancer cell replication and nuclear uptake of estradiol in MCF-7 cell cultures. Int. J. Cancer. 54:1993;119-124.
24. Tseng L., Mazella J., Lee L.Y., Stone M.L. Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma. J. Steroid Biochem. 19:1983;1413-1417.
25. Godefroi V.C., Locke E.R., Singh D.V., Brooks S.C. The steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors. Cancer Res. 35:1975;1791-1798.
26. Adams J.B., Philips N.S., Hall R. Metabolic fate of estradiol in human mammary cancer cells in culture: estrogen sulfate formation and cooperativity exhibited by estrogen sulfotransferase. Molec. Cell. Endocr. 58:1988;231-242.
27. Pasqualini J.R., Maloche C., Maroni M., Chetrite G. Effect of the progestagen Promegestone (R-5020) on mRNA of the oestrone sulphatase in the MCF-7 human mammary cancer cells. Anticancer Res. 14:1994;1589-1594.
28. Chetrite G., Le Nestour E., Pasqualini J.R. Human estrogen sulfotransferase (hEST1) activities and its mRNA in various breast cancer cell lines: effect of the progestin, promegestone (R-5020). J. Steroid Biochem. Molec. Biol. 66:1998;295-302.
29. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62:1956;315-323.
30. Anderson E., Howell A. Oestrogen sulphotransferases in malignant and normal human breast tissue. Endocr.-Relat. Cancer. 2:1995;227-233.
31. Bernier F., Leblanc G., Labrie F., Luu-The V. Structure of human estrogen and aryl sulfotransferase gene. J. Biol. Chem. 269:1994;28200-28205.
32. Luu-The V., Bernier F., Dufort I. Steroid sulfotransferases. J. Endocr. 150:1996;S87-S97.
33. Falany C.N., Wheeler J., Oh T.S., Falany J.L. Steroid sulfation by expressed human cytosolic sulfotransferases. J. Steroid Biochem. Molec. Biol. 48:1994;369-375.
34. Hobkirk R. Steroid sulfation: current concepts. Trends Endocr. Metab. 4:1993;69-74.
35. Saunders D.E., Lozon M.M., Corombos J.D., Brooks S.C. Role of porcine endometrial estrogen sulfotransferase in progesterone mediated down-regulation of estrogen receptor. J. Steroid Biochem. 32:1989;749-757.
36. Roy A.K. Regulation of steroid hormone action in target cells by specific hormone-inactivating enzymes. Proc. Soc. Experim. Biol. Med. 199:1992;265-272.
37. Nash A.R., Glenn W.K., Moore S.S., Kerr J., Thompson A.R., Thompson E.O.P. Oestrogen sulfotransferase: molecular cloning and sequencing of cDNA for the bovine placental enzyme. Aust. J. Biol. Sci. 41:1988;507-516.
38. Reddel R.R., Sutherland R.L. Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare. Eur. J. Cancer Clin. Oncol. 20:1984;1419-1424.
39. Adams J.B., Philips N.S. Properties of estrogen and hydroxysteroid sulphotransferases in human mammary cancer. J. Steroid Biochem. 36:1990;695-701.
40. Falany J.L., Lawing L., Falany C.N. Identification and characterization of cytosolic sulfotransferase activities in MCF-7 human breast carcinoma cells. J. Steroid Biochem. Molec. Biol. 46:1993;481-487.
41. Sharp S., Anderson J.M., Coughtrie M.W.H. Immunohistochemical localization of hydroxysteroid sulphotransferase in human breast carcinoma tissue: a preliminary study. Eur. J. Cancer. 30A:1994;1654-1659.
42. Dooley T.P. Cloning of the human phenol sulfotransferase gene family: three genes implicated in the metabolism of catecholamines, thyroid hormones and drugs. Chem.-Biol. Interactions. 109:1998;29-41.
43. Chetrite G.S., Kloosterboer H.J., Pasqualini J.R. Effect of tibolone (Org OD14) and its metabolites on estrone sulphatase activity in MCF-7 and T-47D mammary cancer cells. Anticancer Res. 17:1997;135-140.
44. Pasqualini J.R., Varin C., Nguyen B-L. Effect of the progestagen R5020 (promegestone) and of progesterone on the uptake and on the transformation of estrone sulfate in the MCF-7 and T-47D human mammary cancer cells: correlation with progesterone receptor levels. Cancer Lett. 66:1992;55-60.
45. Chetrite G., Blumberg-Tick J., Pasqualini J.R. Effect of Decapeptyl® (a GnRH analogue) and of transforming growth factor-α (TGF-α), in the presence of heparin, on the sulfatase activity of human breast cancer cells. J. Steroid Biochem. Molec. Biol. 52:1995;451-457.
46. Nguyen B-L., Fermé I., Chetrite C., Pasqualini J.R. Action of danazol on the conversion of estrone sulfate to estradiol and on the sulfatase activity in the MCF-7, T-47D and MDA-231 human mammary cancer cells. J. Steroid Biochem. Molec. Biol. 46:1993;17-23.
47. Chetrite G., Paris J., Botella J., Pasqualini J.R. Effect of nomegestrol acetate on estrone-sulfatase and 17β-hydroxysteroid dehydrogenase activities in human breast cancer cells. J. Steroid Biochem. Molec. Biol. 58:1996;525-531.
48. Pasqualini J.R., Chetrite G., Nguyen B-L., Maloche C., Delalonde L., Talbi M., Feinstein M.-C., Blacker C., Botella J., Paris J. Estrone sulfate-sulfatase and 17β-hydroxysteroid dehydrogenase activities: a hypothesis for their role in the evolution of human breast cancer from hormone-dependence to hormone-independence. J. Steroid Biochem. Molec. Biol. 53:1995;407-412.
49. Chetrite G., Varin C., Delalonde L., Pasqualini J.R. Effect of promegestone, tamoxifen, 4-hydroxytamoxifen and ICI 164,384 on the oestrone sulphatase activity of human breast cancer cells. Anticancer Res. 13:1993;931-934.