Restoration of human B-cell differentiation Into NOD-SCID mice engrafted with gene-corrected CD34+ cells isolated from artemis or RAG1-deficient patients

Molecular Therapy

Volumn 16, Issue 2, 2008, Pages 396-403

  Lagresle Peyrou, Chantal ^a,b   Benjelloun, Fatine ^a,b   Hue, Christophe ^a,b   Andre Schmutz, Isabelle ^a,b   Bonhomme, Delphine ^c   Forveille, Monique ^a   Beldjord, Kheira ^d   Hacein Bey Abina, Salima ^a,b,d   De Villartay, Jean Pierre ^a,b,d   Charneau, Pierre ^e   Durandy, Anne ^a,b   Fischer, Alain ^a,b,d   Cavazzana Calvo, Marina ^a,b,d  

^a Necker Branch   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Cytheris   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; IMMUNOGLOBULIN M; INTERLEUKIN 2 RECEPTOR ANTIBODY; INTERLEUKIN 2 RECEPTOR BETA; LENTIVIRUS VECTOR; RAG1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW TRANSPLANTATION; CELL ISOLATION; CELL MATURATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; NONVIRAL GENE THERAPY; OUTCOME ASSESSMENT; PROTEIN DEFICIENCY; SCID MOUSE; VIRAL GENE DELIVERY SYSTEM;

MUS;

EID: 38649123723     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/sj.mt.6300353     Document Type: Article

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