Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34+ cells

Blood

Volumn 99, Issue 5, 2002, Pages 1620-1626

  Kerre, Tessa C C ^a,b,c,d   De Smet, Greet ^a,b,c,d   De Smedt, Magda ^a,b,c,d   Zippelius, Alfred ^a,b,c,d   Pittet, Mikaël J ^a,b,c,d   Langerak, Anton W ^a,b,c,d   De Bosscher, José ^a,b,c,d   Offner, Fritz ^a,b,c,d   Vandekerckhove, Bart ^a,b,c,d   Plum, Jean ^a,b,c,d  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d BTC Oost Vlaanderen   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ANIMAL MODEL; ARTICLE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE; THYMOCYTE;

EID: 0036493602     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.5.1620     Document Type: Article

References (26)

1. Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex-vivo-expanded human CD34+ cord blood cells
2. Engraftment and development of human CD34+-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice
3. A newly discovered class of human hematopoietic cells with SCID-repopulating activity
4. Human cord blood progenitors sustain thymic T-cell development and a novel form of angiogenesis
5. Distinct classes of human stem cells that differ in proliferative and self-renewal potential
6. The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function
7. + precursor cells
8. + fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment
9. Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells
10. Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody
11. A novel monoclonal antibody against murine IL-2 receptor beta-chain: Characterization of receptor expression in normal lymphoid cells and EL-4 cells
12. Cytokine dependence of V gamma 3 thymocytes: Mature but not immature V gamma 3 cells require endogenous IL-2 and IL-7 to survive: Evidence for cytokine redundancy
13. Changes in thymic function with age and during the treatment of HIV infection
14. Molecular and flow cytometric analysis of the Vβ repertoire for clonality assessment in mature TCRαβ T-cell proliferations
15. Murine IL-2 receptor β-chain blockade improves human leukocyte engraftment in SCID mice
16. Dissecting NK cell development using a novel alymphoid mouse model: Investigating the role of the c-ab/proto-oncogene in murine NK cell differentiation
17. Down-regulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development
18. 11-Color, 13-parameter flow cytometry: Identification of human naive T cells by phenotype, function, and T-cell receptor diversity
19. + T cells
20. Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice
21. A novel immunodeficient mouse model - RAG2 x common cytokine receptor gamma chain double mutants - Requiring exogenous cytokine administration for human hematopoietic stem cell engraftment
22. Emv30null NOD-scid mice: An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells
23. + cells
24. + thymocytes and identification of thymic emigrants
25. Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent
26. Both CD34+38+ and CD34+38- cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion