Similar myeloid recovery despite superior overall engraftment in NOD/SCID mice after transplantation of human CD34+ cells from umbilical cord blood as compared to adult sources

Bone Marrow Transplantation

Volumn 28, Issue 2, 2001, Pages 163-171

  Noort, W A ^a   Wilpshaar, J ^a   Hertogh, C D P ^a   Rad, M ^a   Lurvink, E G A ^a   Van Luxemburg Heijs, S A P ^a   Zwinderman, K ^a   Verwey, R A ^b   Willemze, R ^a   Falkenburg, J H F ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MEDICAL CENTER HAAGLANDEN   (Netherlands)

Author keywords

Human CD34+ cells; Myeloid engraftment; NOD SCID mice; Transplantation

Indexed keywords

ANTIBODY; CD34 ANTIGEN; CD45 ANTIGEN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BLOOD; BONE MARROW; BONE MARROW CELL; CELL COUNT; CELL LINEAGE; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; LIVER; LYMPHOID CELL; MOUSE STRAIN; NONHUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; SCID MOUSE; SPLEEN; SURGICAL TECHNIQUE; THYMUS; TIME; UMBILICAL CORD BLOOD;

ADULT; ANIMALS; ANTIGENS, CD; ANTIGENS, CD34; BONE MARROW CELLS; FETAL BLOOD; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT, NEWBORN; LIVER; MICE; MICE, INBRED NOD; MICE, SCID; SPLEEN; THYMUS GLAND; TRANSPLANTATION, HETEROLOGOUS;

EID: 0034898541     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703120     Document Type: Article

References (35)

1. Uses and growth of hematopoietic cell transplantation
2. Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies. A retrospective comparison with marrow transplantation
3. Allogeneic blood stem cell transplantation in advanced hematologic cancers
4. Allogeneic blood stem cell (BSC) vs bone marrow transplantation (BMT); improved leukemia free survival in high risk but not low risk patients
5. Placental and/or umbilical cord blood: An alternative source of hematopoietic stem cells for transplantation
6. Outcomes among 562 recipients of placental blood transplants from unrelated donors
7. Outcome of cord-blood transplantation from related and unrelated donors
8. - cells in cord blood and bone marrow
9. + human hematopoietic progenitors from fetal liver, cord blood and adult bone marrow respond differently to hematopoietic cytokines depending on the ontogenic source
10. In vivo engraftment potential of clinical hematopoetic grafts
11. Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow
12. Cord blood progenitor cells have greater transendothelial migratory activity and increased responses to SDF-1 and MIP-3beta compared with mobilized adult progenitor cells
13. + cells in NOD/SCID mice
14. + cells an enhanced ex vivo expansion potential
15. + cells derived from human fetal liver as compared to fetal bone marrow
16. Hematopoietic and immune recovery after transplantation of cord blood progenitor cells in children
17. Immunological reconstitution and correlation of circulating serum inflammatory mediators/cytokines with the incidence of acute graft-versus-host disease during the first 100 days following unrelated transplantation
18. Immune recovery post unrelated allogeneic umbilical cord blood (UCB) transplantation in adult recipients
19. Reconstitution of the immune system after unrelated or partially matched T-cell-depleted bone marrow transplantation in children: Immunophenotypic analysis and factors affecting the speed of recovery
20. Phenotypic and functional reconstitution of peripheral blood lymphocytes following T cell-depleted bone marrow transplantation from partially mismatched related donors
21. High gradient magnetic cell separation with MACS
22. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
23. Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood
24. +-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice
25. - cells
26. The number and generative capacity of human B lymphocyte progenitors, measured in vitro and in vivo, is higher in umbilical cord blood than in adult or pediatric bone marrow
27. Comparison of hematopoietic activities of human bone marrow and umbilical cord blood CD34 positive and negative cells
28. + peripheral blood progenitor cells
29. Seeding efficiency of primitive human hematopoietic cells in nonobese diabetic/severe combined immune deficiency mice: Implications for stem cell frequency assessment
30. A newly discovered class of human hematopoietic cells with SCID-repopulating activity
31. + cells
32. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay
33. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
34. Purification of primitive human hematopoietic cells capable of repopulating immunodeficient mice
35. Ex vivo expansion of cord blood cells: The clinical potential