Increased levels of circulating progenitor cells after 1-week sojourn at moderate altitude (Austrian Moderate Altitude Study II, AMAS II)

Respiratory Physiology and Neurobiology

Volumn 160, Issue 2, 2008, Pages 232-238

  Theiss, Hans D ^a   Adam, Michaela ^a   Greie, Sven ^b   Schobersberger, Wolfgang ^b   Humpeler, Egon ^b,c   Franz, Wolfgang M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY FOR HEALTH SCIENCES   (Austria)

^c Institute Humpeler Schobersberger GmbH   (Austria)

Author keywords

Altitude; Hypoxia; Prevention; Progenitor cell; Stem cell

Indexed keywords

CD31 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN;

ADULT; ALTITUDE; ARTICLE; CD34 SELECTION; CELL POPULATION; CIRCULATION; CLINICAL STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; STEM CELL;

ADAPTATION, PHYSIOLOGICAL; ADULT; ADULT STEM CELLS; ALTITUDE; ANTIGENS, CD34; EXERCISE; FEMALE; HUMANS; LYMPHOCYTE SUBSETS; MALE; RECEPTORS, CXCR4; REFERENCE VALUES; TIME FACTORS;

EID: 38649109104     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2007.10.006     Document Type: Article

References (31)

1. Abbott J.D., Huang Y., Liu D., Hickey R., Krause D.S., and Giordano F.J. Stromal cell-derived factor-1 alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110 23 (2004) 3300-3305
2. Adams V., Lenk K., Linke A., Lenz D., Erbs S., Sandri M., Tarnok A., Gielen S., Emmrich F., Schuler G., and Hambrecht R. Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler. Thromb. Vasc. Biol. 24 4 (2004) 684-690
3. Asahara T., Takahashi T., Masuda H., Kalka C., Chen D., Iwaguro H., Inai Y., Silver M., and Isner J.M. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J. 18 15 (1999) 3964-3972
4. Askari A.T., Unzek S., Popovic Z.B., Goldman C.K., Forudi F., Kiedrowski M., Rovner A., Ellis S.G., Thomas J.D., DiCorleto P.E., Topol E.J., and Penn M.S. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 362 30 (2003) 697-703
5. Ceradini D.J., Kulkarni A.R., Callaghan M.J., Tepper O.M., Bastidas N., Kleinman M.E., Capla J.M., Galiano R.D., Levine J.P., and Gurtner G.C. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med. 10 (2004) 858-864
6. Dempsey J.A., and Wagner P.D. Exercise-induced arterial hypoxemia. J. Appl. Physiol. 87 6 (1999) 1997-2006
7. Goette A., Jentsch-Ullrich K., Lendeckel U., Rocken C., Agbaria M., Auricchio A., Mohren M., Franke A., and Klein H.U. Effect of atrial fibrillation on hematopoietic progenitor cells: a novel pathophysiological role of the atrial natriuretic peptide?. Circulation 108 20 (2003) 2446-2449
8. Greie S., Humpeler E., Gunga H.C., Koralewski E., Klingler A., Mittermayr M., Fries D., Lechleitner M., Hoertnagl H., Hoffmann G., Strauss-Blasche G., and Schobersberger W. Improvement of metabolic syndrome markers through altitude specific hiking vacations. J. Endocrinol. Invest. 29 6 (2006) 497-504
9. Gunga H.C., Fries D., Humpeler E., Kirsch K., Boldt L.E., Koralewski E., Johannes B., Klingler A., Mittermayr M., Rocker L., Yaban B., Behn C., Jelkmann W., and Schobersberger W. Austrian Moderate Altitude Study (AMAS 2000)-fluid shifts, erythropoiesis, and angiogenesis in patients with metabolic syndrome at moderate altitude (congruent with 1700 m). Eur. J. Appl. Physiol. 88 6 (2003) 497-505
10. Gunga, H.C., Kirsch, K.A., Roecker, L. Kohlberg, E., Tiedemann, J., Steinach, M., Schobersberger, W., 2007. Erythropoietin regulations in humans under different environmental and experimental conditions. Respir. Physiol. Neurobiol. 12 [Epub ahead of print].
11. Hattori K., Heissig B., Tashiro K., Honjo T., Tateno M., Shieh J.H., Hackett N.R., Quitoriano M.S., Crystal R.G., Rafii S., and Moore M.A. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 97 1 (2001) 3354-3360
12. Joint National Committee. The sixth report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure (JNC VI). Arch. Int. Med. 157 (1997) 2413-2416
13. Kocher A.A., Schuster M.D., Szabolcs M.J., Takuma S., Burkhoff D., Wang J., Homma S., Edwards N.M., and Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. 7 (2001) 430-436
14. Kollet O., Shivtiel S., Chen Y.Q., Suriawinata J., Thung S.N., Dabeva M.D., Kahn J., Spiegel A., Dar A., Samira S., Goichberg P., Kalinkovich A., Arenzana-Seisdedos F., Nagler A., Hardan I., Revel M., Shafritz D.A., and Lapidot T. HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. J. Clin. Invest. 112 2 (2003) 160-169
15. Laufs U., Werner N., Link A., Endres M., Wassmann S., Jurgens K., Miche E., Bohm M., and Nickenig G. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109 2 (2004) 220-226
16. Laufs U., Urhausen A., Werner N., Scharhag J., Heitz A., Kissner G., Bohm M., Kindermann W., and Nickenig G. Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects. Eur. J. Cardiovasc. Prev. Rehabil. 12 4 (2005) 407-414
17. Leuner S., Arland M., Kahl C., Jentsch-Ullrich K., Franke A., and Hoffkes H.G. Enumeration of CD34-positive hematopoietic progenitor cells by flow cytometry: comparison of a volumetric assay and the ISHAGE gating strategy. Bone Marrow Transplant. 22 7 (1998) 699-706
18. Mollard P., Woorons X., Letournel M., Lamberto C., Favret F., Pichon A., Beaudry M., and Richalet J.-P. Determinants of maximal oxygen uptake in moderate acute hypoxia in endurance athletes. Eur. J. Appl. Physiol. 100 (2007) 663-673
19. Peichev M., Naiyer A.J., Pereira D., Zhu Z., Lane W.J., Williams M., Oz M.C., Hicklin D.J., Witte L., Moore M.A., and Rafii S. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood 95 1 (2000) 952-958
20. Sandri M., Adams V., Gielen S., Linke A., Lenk K., Krankel N., Lenz D., Erbs S., Scheinert D., Mohr F.W., Schuler G., and Hambrecht R. Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation 111 25 (2005) 3391-3399 Epub 2005 Jun 13
21. Schobersberger W., Schmid P., Lechleitner M., von Duvillard S.P., Hortnagl H., Gunga H.C., Klingler A., Fries D., Kirsch K., Spiesberger R., Pokan R., Hofmann P., Hoppichler F., Riedmann G., Baumgartner H., and Humpeler E. Austrian Moderate Altitude Study 2000 (AMAS 2000). The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome. Eur. J. Appl. Physiol. 88 6 (2003) 506-514
22. Schobersberger W., Greie S., Humpeler E., Mittermayr M., Fries D., Schobersberger B., Artner-Dworzak E., Hasibeder W., Klingler A., and Gunga H.C. Austrian Moderate Altitude Study (AMAS 2000): erythropoietic activity and Hb-O(2) affinity during a 3-week hiking holiday at moderate altitude in persons with metabolic syndrome. High Alt. Med. Biol. 6 2 (2005) 167-177
23. Shintani S., Murohara T., Ikeda H., Ueno T., Honma T., Katoh A., Sasaki K., Shimada T., Oike Y., and Imaizumi T. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 103 12 (2001) 2776-2779
24. Steiner S., Niessner A., Ziegler S., Richter B., Seidinger D., Pleiner J., Penka M., Wolzt M., Huber K., Wojta J., Minar E., and Kopp C.W. Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis 181 2 (2005) 305-310
25. St-Onge M., Mignault D., Allison D.B., and Rabasa-Lhoret R. Evaluation of a portable device to measure daily energy expenditure in free-living adults. Am. J. Clin. Nutr. 85 3 (2007) 742-749
26. Tang Y.L., Tang Y., Zhang Y.C., Qian K., Shen L., and Phillips M.I. Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J. Am. Coll. Cardiol. 46 7 (2005) 1339-1350
27. Vasa M., Fichtlscherer S., Adler K., Aicher A., Martin H., Zeiher A.M., and Dimmeler S. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103 24 (2001) 2885-2890
28. Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H., Zeiher A.M., and Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ. Res. 89 6 (2001) E1-E7
29. Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., Bohm M., and Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N. Engl. J. Med. 353 10 (2005) 999-1007
30. Yamaguchi J., Kusano K.F., Masuo O., Kawamoto A., Silver M., Murasawa S., Bosch-Marce M., Masuda H., Losordo D.W., Isner J.M., and Asahara T. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 107 11 (2003) 1322-1328
31. Yoshioka T., Ageyama N., Shibata H., Yasu T., Misawa Y., Takeuchi K., Matsui K., Yamamoto K., Terao K., Shimada K., Ikeda U., Ozawa K., and Hanazono Y. Repair of infarcted myocardium mediated by transplanted bone marrow-derived CD34+ stem cells in a nonhuman primate model. Stem Cells 23 3 (2005) 355-364