Austrian moderate altitude study (AMAS 2000): Erythropoietic activity and Hb-O2 affinity during a 3-week hiking holiday at moderate altitude in persons with metabolic syndrome

High Altitude Medicine and Biology

Volumn 6, Issue 2, 2005, Pages 167-177

  Schobersberger, Wolfgang ^a   Greie, Sven ^a   Humpeler, Egon ^b   Mittermayr, Markus ^c   Fries, Dietmar ^c   Schobersberger, Beatrix ^b   Artner Dworzak, Erika ^c   Hasibeder, Walter ^d   Klingler, Anton ^c   Gunga, Hanns Christian ^e  

^a UNIVERSITY FOR HEALTH SCIENCES   (Austria)

^b Institute Humpeler Schobersberger GmbH   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d District Hospital Barmherzige Schwestern   (Austria)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Erythropoiesis; Erythropoietin; Hypertension; Hypoxia; Obesity

Indexed keywords

ERYTHROPOIETIN; FERRITIN; HEMOGLOBIN; IRON; OXYGEN; TRANSFERRIN;

ADAPTATION; ADULT; ALTITUDE DISEASE; ARTICLE; BINDING AFFINITY; BLOOD OXYGEN TENSION; BLOOD PH; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE COUNT; ERYTHROPOIESIS; FIELD EXPERIMENT; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; HYPOXIA; MALE; MEAN CORPUSCULAR HEMOGLOBIN; METABOLIC SYNDROME X; OXYGEN DISSOCIATION CURVE; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETICULOCYTE COUNT; STANDARDIZATION; TIME; TOURISM; VOLUNTEER;

ACCLIMATIZATION; ALTITUDE; ANALYSIS OF VARIANCE; AUSTRIA; ERYTHROPOIESIS; ERYTHROPOIETIN; FOLLOW-UP STUDIES; HEMOGLOBINS; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OXYGEN CONSUMPTION; PROSPECTIVE STUDIES; RETICULOCYTE COUNT; TIME FACTORS;

EID: 25844530063     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2005.6.167     Document Type: Article

References (30)

1. Abbrecht P.H., and Littell J.K. (1972). Plasma erythropoietin in men and mice during acclimatization to different altitudes. J. Appl. Physiol. 32:54-58.
2. Birgegard G., and Sandhagen B. (2001). Erythropoietin treatment can increase 2,3-diphosphoglycerate levels in red blood cells. Scand. J. Clin. Lab. Invest. 61:337-340.
3. Buchwald H., O'Dea T.J., Menchaka H.J., Van Michalek N., and Rohde T.D. (2000). Effect of plasma cholesterol on red blood cell oxygen transport. Clin. Exp. Pharmacol. Physiol. 27:951-955.
4. de Paula E., and Meirelles N.C. (1992). Interactions between vasodilator drugs and human hemoglobin. Braz. J. Med. Biol. Res. 25:557-565.
5. Eckardt K.U., Boutellier U., Kurtz A., Schopen M., Koller E.A., and Bauer C. (1989). Rate of erythropoietin in humans in response to acute hypobaric hypoxia. J. Appl. Physiol. 66:1785-1788.
6. Fisher J.W. (2003). Erythropoietin: physiology and pharmacology update. Exp. Biol. Med. (Maywood) 228:1-14.
7. Friedmann B., Jost J., Rating T., Weller E., Werle E., Eckardt K.-U., Bärtsch P., and Mairbäurl H. (1999). Effects of iron supplementation on total body haemoglobin during endurance training at moderate altitude. Int. J. Sports Med. 20:78-85.
8. Ge R.L., Witkowski S., Zhang Y., Alfrey C., Sivieri M., Karlsen T., Resaland G.K., Harber M., Stray-Gundersen J., and Levine B.D. (2002). Determinants of erythropoietin release in response to short-term hypobaric hypoxia. J. Appl. Physiol. 92:2361-2367.
9. 2max in world champion track cyclists. J. Sci. Med. Sport 1:156-170.
10. Gunga H.C., Fries D., Humpeler E., Kirsch K., Boldt L.-E., Koralewski E., Johannes B., Klingler A., Mittermayr M., Röcker L., Yaban B., Behn C., Jelkmann W., and Schobersberger W. (2003). Austrian Moderate Altitude Study (AMAS 2000) - fluid shifts, erythropoiesis, and angiogenesis in patients with metabolic syndrome at moderate altitude (1700 m). Eur. J. Appl. Physiol. 88:497-505.
11. Gunga H.C., Kirsch K., Röcker L., and Schobersberger W. (1994). Time course of erythropoietin, triiodothyronine, thyroxine, and thyroid-stimulating hormone at 2.315 m. J. Appl. Physiol. 73:1068-1072.
12. Gunga H.C., Kirsch K., Roecker L., and Schobersberger W. (2002). Erythropoietin regulation in humans during exercise and in extreme environments. In: Erythropoietin: Molecular Biology and Clinical Use, W. Jelkmann, ed. F.P. Graham Publishing Co., Johnson City, TN, pp. 219-244.
13. Gunga H.C., Röcker L., Behm C., Hildebrandt W., Koralewski E., Rich I., Schobersberger W., and Kirsch W. (1996). Shift working in the Chilean Andes (>3,600 m) and its influence on erythropoietin and the low-pressure system. J. Appl. Physiol. 81: 846-852.
14. Humpeler E., Inama K., and Deetjen P. (1979). Improvement of tissue oxygenation during a 20-days stay at moderate altitude in connection with mild exercise. Klin. Wochenschrift 57:267-272.
15. Knaupp W., Khilnani S., Sherwood J., Scharf S., and Steinberg H. (1992). Erythropoietin response to acute normobaric hypoxia in humans. J. Appl. Physiol. 73: 837-840.
16. Koistinen P.O., Rusko H., Irjala K., Rajamaki A., Penttinen K., Sarparanta V.P., Karpakka J., and Leppaluoto J. (2000). EPO, red cells, and serum transferrin receptor in continuous and intermittent hypoxia. Med. Sci. Sports Exerc. 32:800-804.
17. Mairbäurl H. (1994). Red blood cell function in hypoxia at altitude and exercise. Int. J. Sports Med. 15:51-63.
18. Mairbäurl H., Schobersberger W., Humpeler E., Hasibeder W., Fischer W., and Raas E. (1986). Beneficial effects of exercising at moderate altitude on red cell oxygen transport and on exercise performance. Pflügers Arch. 406:594-599.
19. Mairbäurl H., Schobersberger W., Oelz O., Bärtsch P., Eckardt K.-U., and Bauer C. (1990). Unchanged in vivo P50 at high altitude decreased erythrocyte age and elevated 2,3-diphosphoglycerate. J. Appl. Physiol. 68: 1186-1194.
20. Meigs J.B., Wilson P.W.F., Nathan D.M., D'Agostino R.B., Williams K., and Haffner S.M. (2003). Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offsprings Studies. Diabetes 52:2160-2167.
21. Milledge J.S., and Coates P.M. (1985). Serum erythropoietin in humans at high altitude and its relation to plasma renin. J. Appl. Physiol. 59:360-364.
22. National Cholesterol Education Program. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) (2001). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486-2497.
23. Perutz M.F., and Poyart C. (1983). Bezafibrate lowers oxygen affinity of haemoglobin. Lancet 2:881-882.
24. Poyart C., Marden M.C., and Kister J. (1994). Bezafibrate derivatives as potent effectors of hemoglobin. Methods Enzymol. 232:496-513.
25. 2 delivery in dog muscle in situ. J. Appl. Physiol. 84:995-1002.
26. Roberts D., and Smith D.J. (1992). Training at moderate altitude: iron status of elite male swimmers. J. Lab. Clin. Med. 120:387-391.
27. Samaja M., Crespi T., Guazzi M., and Vandegriff K.D. (2003). Oxygen transport in blood at high altitude: role of the haemoglobin-oxygen affinity and impact of the phenomena related to haemoglobin allosterism and red cell function. Eur. J. Appl. Physiol. 90:351-359.
28. Schmidt W., Böning D., Maassen N., et al. (1994). Die bedeutung des blutvolumens für den ausdauersportler. Leistungssport 5:27-37.
29. Schrumpf J.D., Sheps D.S., Wolfson S., Aronson A.L., and Cohen L.S. (1977). Altered haemoglobin-oxygen affinity with long-term propranolol therapy in patients with coronary artery disease. Am. J. Cardiol. 40:76-82.
30. World Health Organization. (1999). Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. Report of a WHO Consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva, Switzerland (WHO/NCD/NCS/99.2).