Austrian Moderate Altitude Study 2000 (AMAS 2000). The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome

European Journal of Applied Physiology

Volumn 88, Issue 6, 2003, Pages 506-514

  Schobersberger, Wolfgang ^b   Schmid, Peter ^c   Lechleitner, Monika ^d   von Duvillard, Serge P ^e,i   Hörtnagl, Helmut ^f   Gunga, Hanns Christian ^a   Klingler, Anton ^g   Fries, Dietmar ^b   Kirsch, Karl ^a   Spiesberger, Reinhard ^h   Pokan, Rochus ^h   Hofmann, Peter ⁱ   Hoppicher, Fritz ^j   Riedmann, Gebhard ^k   Baumgartner, Holger ^l   Humpeler, Egon ^m  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Klinische Abteilung fur Allgemeine   (Austria)

^c Rehabilitations Kurzentrum Austria   (Austria)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^e UNIVERSITY OF NORTH DAKOTA   (United States)

^f Institut fur Sport /Kreislaufmedizin   (Austria)

^g Labor fur Theoretische Chirurgie   (Austria)

^h UNIVERSITY OF VIENNA   (Austria)

ⁱ UNIVERSITY OF GRAZ   (Austria)

^j KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Austria)

^k Osterreichische Gessell fur Alpin   (Austria)

^l UNIVERSITY OF INNSBRUCK   (Austria)

^m Institute Humpeler Schobersberger GmbH   (Austria)

more..

Author keywords

Altitude; Coronary heart disease; Hypertension; Metabolic syndrome; Obesity

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ALTITUDE ACCLIMATIZATION; ARTICLE; AUSTRIA; BICYCLE ERGOMETER; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; CARDIOVASCULAR SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; GLUCOSE BLOOD LEVEL; HEART RATE; HEART VENTRICLE EXTRASYSTOLE; HOLTER MONITORING; HUMAN; INSULIN RESISTANCE; LEISURE; LIPID METABOLISM; MALE; METABOLIC DISORDER; METABOLISM; ORAL GLUCOSE TOLERANCE TEST; PHYSICAL CAPACITY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SIMULATION; SPORT; ST SEGMENT;

EID: 0037635331     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-002-0736-8     Document Type: Article

References (43)

1. Aitbaev KA, Madaminov I, Meimanaliev TS, Shleifer EZ, Kim NM (1990) Study of the effect of migration to high-mountain regions on the blood lipoprotein system. Kosm Biol Aviakosm Med 24:45-46
2. Alexander JK (1994) Coronary heart disease at altitude. Tex Heart Inst J 21:261-266
3. Auwerks J, Staels B (1998) Leptin. Lancet 351:737-742
4. Bernardi L, Passino C, Spadacini G, Calciati A, Robergs R et al (1998) Cardiovascular autonomic modulation and activity of carotid baroreceptors at altitude. Clin Sci (Lond) 95:565-573
5. Björntorp P (1999). Neuroendocrine perturbations as a cause of insulin resistance. Diabetes Metab Res Rev 15:427-441
6. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F et al (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 1:57-63
7. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS et al (1991) Increased dependence on blood glucose after acclimatization to 4300 m. J Appl Physiol 70:919-927
8. Consolazio CF, Jonston HL, Krzywicki HJ, Daws TA (1972) Metabolic aspects of acute altitude exposure (4,300 meters) in adequately nourished humans. Am J Clin Nutr 25: 23-29
9. DeFronzo RA, Ferrannini E (1991) Insulin resistance :a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:291-299
10. Dominguez Coello SD, Cabrera De Leon A, Bosa Ojeda F, Perez Mendez LI, Diaz Gonzalez L, Aguirre-Jaime AJ (2000) High density lipoprotein cholesterol increases with living altitude. Int J Epidem 29:65-70
11. Duplain M, Vollenweider L, Delebays A, Nicod P, Bartsch P, Scherrer U (1999) Augmented sympathetic activation during short term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 13:1713-1718
12. Erdmann J, Sun KT, Masar P, Niederhauser H (1998) Effects of exposure to altitude on men with coronary artery disease and impaired left ventricular dysfunction. Am J Cardiol 81:266-270
13. Ferezou J, Richalet JP, Serougne C, Coste T, Wirquin E, Mathe D (1993) Reduction of postprandial lipemia after acute exposure to high altitude hypoxia. Int J Sports Med 14:78-85
14. Fischer R (1998) Trekking trotz Herzerkrankung. Fortschr Med 116:42-43
15. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 18:499-502
16. Gunga H-Ch, Fries D, Humpeler E, Kirsch K, Boldt L-E, Koralewski E, Johannes B, Klingler A, Mittermayr M, Röcker L, Yaban B, Behn C, Jelkmann W, AMAS-Res Team, Schobersberger W (2002) Austrian Moderate Altitude Study (AMAS 2000) - fluid shifts, erythropoiesis, and angiogenesis in patients with metabolic syndrome at moderate altitude (≅1,700 m). Eur J Appl Physiol DOI 10.1007/s00421-002-0734-x
17. Halhuber MJ, Humpeler E, Inama R, Jungmarm H (1985) Does altitude cause exhaustion of the heart and circulatory system? Med Sport Sci 19:192-202
18. Hultgren HN (1992) Effects of altitude upon cardiovascular diseases. J Wilderness Med 3:301-308
19. Inama K, Halhuber MJ (1975) Der Herz-Kreislaufkranke im Hochgebirgsklima. Untersuchungen im Kühtai (Tirol) und Obertauern (Salzburg) während kombinierter Klima-Terrainkuren in 1.800 bis 2.500 NN in den Jahren 1965 his 1971. Deutsche Zentrale für Volksgesundheitspflege e.V., Schriftenreihe Heft 25, Frankfurt
20. Inama K, Humpeler E (1981) Alpine Höhenlagen als Therapie-faktor bei Herz- Kreislauf-Erkrankungen. In: Deetjen P, Humpeler E (eds) Medizinische Aspekte der Höhe. Thieme, New York, pp 91-103
21. Joint National Committee (1997) The sixth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI). Arch Intern Med 157:2413-2446
22. Kayser B (1992) Nutrition and high altitude exposure. Int J Sports Med 13:S129-S132
23. Kennedy SL, Stanley WC, Panchal AR, Mazzeo RS (2001) Alterations in enzymes involved in fat metabolism after acute and chronic altitude exposure. J Appl Physiol 90:17-22
24. Larsen JJ, Hansen JM, Olsen NV, Galbo H, Delta F (1997) The effect of altitude hypoxia on glucose homeostasis in men. J Physiol (Lond) 504:241-249
25. Levine BD, Zuckermann JH, Filipi CR (1997) Effect of high-altitude exposure in the elderly: The Tenth Mountain Division study. Circulation 96:1224-1232
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RL (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
27. Mazzeo RS, Child A, Butterfield GE, Mawson JT, Zamudion S, Moore LG (1998) Catecholamine response during 12 days of high-altitude exposure (4,300 m) in women. J Appl Physiol 84:1151-1155
28. Morgan BJ, Alexander JK, Nicoli SA, Brammel HI (1990) The patient with coronary heart disease at altitude: observations during acute exposure to 3100 meters. J Wilderness Med 1:147-153
29. Nikolowa P, Dikova M, Dimitrowa D (1989) Klimatotherapie von Kranken mit ischämischer Herzkrankheit in mittelhohen Gebirgen. Z Physiother 41:109-114
30. Palatini P, Businaro R, Berton G, Mormino P, Rossi G et al (1989) Effects of low altitude exposure on 24 h blood pressure and adrenergic activity. Am J Cardiol 64:1379-1382
31. Patsch W, Brown SA, Morrisett J, Gotto AM Jr, Patsch JR (1989) A dual precipitation method evaluated for measurement of cholesterol in high-density lipoprotein HDL2 and HDL3 in human plasma. Clin Chem 35:265-270
32. Pokan R, Eber B, Fruhwald FM, Brusse H, Grisold M, Klein W (1994) Körperliche Aktivität in mittleren Höhenlagen bei Gesunden und Patienten mit Koronarsklerose. Wien Med Wschr 7:121-124
33. Reaven GM (1996) Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473-486
34. Roach RC, Houston CS, Honigman B, Nicholas RA, Yaron M et al (1995) How well do older persons tolerate moderate altitude. West J Med 162:32-36
35. Savonitto S, Cardellino G, Sardina M, Chebat E, Baldi G et al (1991) Effects of a cable car trip on blood pressure and cardiovascular hormones in lowlander and highlander normotensives. Cardiologica 36:385-390
36. Sawhney RC, Malhotra AS, Singh T (1991) Glucoregulatory hormones in man at high altitude. Eur J Appl Physiol 62:286-291
37. Sharma S (1990) Clinical, biochemical, electrocardiographic and noninvasive hemodynamic assessment of cardiovascular status in natives at high to extreme altitudes (3000-5500 m) of the Himalayan region. Indian Heart J 42:375-379
38. Smith ML, Muenter NK (2000) Effects of hypoxia on sympathetic neural control in humans. Respir Physiol 121:163-171
39. Steinacker JM, Liu Y, Bärtsch P (2000) Going to high altitude: patients with cardiovascular disease. Dtsch Z Sportmed 51:407-411
40. Thompson PD, Crouse SF, Goodpaster B, Kelley D, Moyna N, Pescatello L (2001) The acute versus the chronic response to exercise. Med Sci Sports Exerc Suppl 33:S438-S445
41. Tschopp M, Strasburger CJ, Hartman G, Biollaz J, Bartsch P (1998) Raised leptin concentrations at higher altitude associated with loss of appetite. Lancet 352:1119-1120
42. Veglio M, Maule S, Cametti G, Cogo A, Lussiana L et al. (1999) The effects of exposure to moderate attitude on cardiovascular autonomic function in normal subjects. Clin Autonom Res 9:123-127
43. Whelton SP, Chin A, Xin X, He J (2002) Effect of aerobic exercise on blood pressure :a meta-analysis of randomized, controlled trials. Ann Intern Med 136:493-503