Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: Possible role of a P-glycoprotein and parasite cyclophilins

Parasitology

Volumn 135, Issue 2, 2008, Pages 217-228

  Bua J ^a,e   Fichera, L E ^a   Fuchs, A G ^b,c   Potenza, M ^a   Dubin, M ^b   Wenger, R O ^d   Moretti, G ^a   Scabone, C M ^a   Ruiz, A M ^a  

^a Administracion Nacional de Laboratorios E Institutos de Salud Dr Carlos G Malbran   (Argentina)

^b Centre de Estudios Farmacologicos y Botanicos   (Argentina)

^c UNIVERSIDAD ABIERTA INTERAMERICANA   (Argentina)

^d Wenger Chemtech   (Switzerland)

^e NONE   (Argentina)

Author keywords

Cyclophilins; Cyclosporin A derivatives; P glycoprotein; Parasiticidal activity; Trypanosoma cruzi

Indexed keywords

AMINOPYRINE N DEMETHYLASE; CYCLOPHILIN; CYCLOSPORIN A; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; CYCLOSPORIN A DERIVATIVE; CYCLOSPORIN A[3 N DEXRO METHYLALANINE 4 ETHYLVALINE]; CYCLOSPORIN A[4 N METHYLVALINE]; F 762; GLYCOPROTEIN P; H 794; PEPTIDYLPROLYL ISOMERASE; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN; RHODAMINE 123; SDZ 208 849; SDZ 208 851; SDZ 220 384; UNCLASSIFIED DRUG; VERAPAMIL;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVITY; ENZYME INHIBITION; EPIMASTIGOTE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MAMMAL CELL; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; TRYPOMASTIGOTE;

AMINOPYRINE N-DEMETHYLASE; ANIMALS; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; CYCLOPHILINS; CYCLOSPORINS; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, INBRED BALB C; P-GLYCOPROTEIN; PEPTIDYLPROLYL ISOMERASE; RHODAMINE 123; TIME FACTORS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; U937 CELLS; VERO CELLS;

MAMMALIA; TRYPANOSOMA CRUZI;

EID: 38549084108     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S003118200700371X     Document Type: Article

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