The effect of immunosuppressive agents (FK-506, rapamycin) on renal P450 systems in rat models

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 8, 1999, Pages 941-948

  Yoshimura, Rikio ^a,b   Yoshimura, Norio ^a   Ohyama, Akira ^a   Ohmachi, Tetsuji ^a   Yamamoto, Keisuke ^a   Kishimoto, Taketoshi ^a   Wada, Seiji ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRINE N DEMETHYLASE; CYCLOSPORIN; CYTOCHROME P450; IMMUNOSUPPRESSIVE AGENT; KIDNEY ENZYME; OXYGENASE; PROSTAGLANDIN A1; RAPAMYCIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; HISTOCHEMISTRY; IMMUNOBLOTTING; KIDNEY; KIDNEY FUNCTION; KIDNEY MICROSOME; MALE; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0032847899     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991773203     Document Type: Article

References (55)

1. Andoh, T. F., Burdmann, E. A., Fransechini, N., Houghton, D. C., Bennet, W. M. (1996) Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK-506. Kidney Int. 50: 1110-1117
2. Bertault-Peres, P., Bonfils, C., Faber, G., Just, S., Cano, J. P., Maurel, P. (1987) Metabolism of cyclosporine A. II. Implication of the macrolide antibiotic-inducible cytochrome P450 3c from rabbit liver microsomes. Drug. Metab. Dispos. 15: 391-398
3. Bram, R. J., Hung, D. T., Martin, P. K., Schreiber, S. L., Grabtree, G. R. (1993) Identification of a immunophilin capable of mediating inhibition of signal transduction by cyclosporin A and FK-506, Role of calcineulin binding and cellular localization. Mol. Cell Biol. 13: 4760-4769
4. Calen, R. Y. (1987) Cyclosporin in cadaveric renal transplantation. Lancet 2: 506-507
5. Coffman, T. M., Carr, D. R., Yarger, W. E., Klotman, P. E. (1987) Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity. Transplantation 43: 282-285
6. Combalbert, J., Fabre, I., Fabre, G., Dalet, I., Derancourt, J., Cano, J. P., Maurel, P. (1989) Metabolism of cyclosporine A. IV. Purification and identification of the rifampicininducible human liver cytochrome P450 (cyclosporine A oxidase) as a product of P450 III A gene subfamily. Drug. Metab. Dispos. 17: 197-207
7. English, J., Evan, A., Houghton, D. C., Bennett, W. M. (1987) Cyclosporine-induced acute renal dysfunction in the rat. Evidence of arteriolar vasoconstriction with preservation of tubular function. Transplantation 44: 135-141
8. Fromm, M. F., Busse, D., Kroemer, H. K., Eichelbaum, M. (1996) Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin. Hepatology 24: 796-801
9. Gan, L. L., Moseley, M. A., Khosla, B., Augustijns, P. F., Bradshaw, T. P., Hendren, R. W., Thakker, D. R. (1996) CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporine A in Caco-2 cells. Drug Metab. Dispos. 24: 344-349
10. Goldberg, H. J., Wong, P. Y., Cole, E. H., Levy, G. A., Skorecki, K. L. (1989) Dissociation between the immunosuppressive activity of cyclosporine derivatives and their effects on intracellular calcium signaling in mesangial cells. Transplantation 47: 731-733
11. Hakim, M., Spiegelbalter, D., English, T. A., Caine, N., Wallwork, J. (1988) Cardiac transplantation with cyclosporine and steroids. Transplant. Proc. 20: 327-332
12. Hariharan, S., Munda, R., Cavello, T., Demmy, A. M., Schroeder, T. J., Alexander, J. W., First, M. R. (1996) Rescue therapy with tacrolimus after combined kidney/pancreas and isolated pancreas transplantation in patients with severe cyclosporine nephrotoxicity. Transplantation 61: 1161-1165
13. Hernandez-Herrera, G., Del Castillo, D., Perez, R., Lopez-Rubio, F., Aljama, P. (1998) Tacrolims rescue therapy for cyclosporine-induced nephrotoxicity. Transpl. Int. 11: 104-106
14. Imai, Y., Hashimoto, Y. G., Satake, K., Girardin, A., Sato, R. (1980) Multiple forms of cytochrome P450 purified from liver microsomes of phenobarbital and 3-methylcholanthrene-pretreated rabbits. Resolution, purification, and molecular properties. J. Biochem. 88: 489-503
15. Iwatsuki, S. (1988) 1000 liver transplants using cyclosporin A. Transplant. Proc. 20: 499-504
16. Kahan, B. D. (1989) Cyclosporine. New Engl. J. Med. 321: 1725-1738
17. Kahan, B. D., Chang, J. Y., Sehgal, S. N. (1991) Preclinical evaluation of a new potent immuno-suppressive agent, rapamycin. Transplantation 52: 185-191
18. 2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases. Biochem. Biophys. Acta 1123: 156-162
19. Kino, T., Hatanaka, H., Hashimoto, M., Nishiyama, M., Goto, T., Okuhara, M., Kohsaka, M., Aoki, H., Imanaka, H. (1987) FK-506, a novel immunosuppressant isolated from Streptomyces. I. Fermentation, isolation, and physicochemical and biological characteristics. J. Antibiot. 1249-1255
20. Krueger, B. A., Trakshel, G. M., Sluss, P. M., Mains, M. D. (1991) Cyclosporin-mediated depression of luteinizing hormone receptors and heme biosynthesis in rat testes: a possible mechanism for decrease in serum testosterone. Endocrinology 129: 2647-2654
21. Kusunose, E., Ogita, K., Ichihara, K., Kusunose, M. (1981) Effect of cytochrome B on fatty acid ω- and (ω-1)-hydroxylation catalyzed by partially purified cytochrome P-450 from rabbit kidney cortex microsomes. J. Biochem. 90: 1069-1076
22. 1 by the microsomes of rabbit intestine mucosa. J. Biochem. 95: 1733-1739
23. Kusunose, M., Kikuta, Y., Kusunose, E. (1989) Isolation of two forms of rabbit hepatic cytochrome P450 with prostaglandin hydroxylase activity. In: Biochemistry and Biophysics, Taylor and Francis, London, p. 129
24. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
25. Machkov'a, Z., Mostech'a, H., Seifert, J., Masek, K. (1990) The effect of cyclosporine A on renal and hepatic microsomal mixed function oxidase systems in rats. Methods. Find. Exp. Clin. Pharmacol. 12: 239-244
26. Marray, B. M., Paller, M. S., Ferris, T. F. (1985) Effect of cyclosporine administration on renal hemodynamics in conscious rats. Kidney Int. 28: 767-774
27. Massicot, F., Thevenin, M., Martin, C., Warnet, J. M., Dutertre-Catella, H., Claude, J. R. (1994) Effects of cyclosporine on kidney glutathione metabolism and cytochrome P450 in the rabbit: possible implication of eicosanoid metabolism. Drug. Chem. Toxicol. 27: 449-462
28. Mayer, R. D., Berman, S., Cockett, A. T., Maines, M. D. (1989) Differential effects of cyclosporine on hepatic and renal heme, cytochrome P450 and drug metabolism. Biochem. Pharmacol. 38: 1001-1007
29. McCauley, J. (1993) The nephrotoxicity of FK506 as compared with cyclosporine. Curr. Opin. Nephrol. Hypertens. 2: 662-669
30. Morris, R. E., Wu, J., Shorthouse, R. (1990) A study of contrasting effects of cyclosporine, FK-506 and rapamycin on the suppression of allograft rejection. Transplant. Proc. 22: 1638-1641
31. Morris-Stiff, G., Baboolal, K., Singh, J., Balaji, V., Ostrowski, K., Moore, R., Lord, R., Jurewicz, A. (1998) Conversion from cyclosporine to tacrolimus in renal allograft recipients with chronic graft nephropathy: Preliminary Report. Transplant. Proc. 30: 1245-1246
32. Morrissey, P. E., Gohh, R., Shaffer, D., Crosson, A., Madras, P. N., Sahyoun, A. I., Monaco, A. P. (1997) Correlation of clinical outcomes after Tacrolims conversion for resistant kidney rejection or cyclosporine toxicity with pathologic staging by the banff criteria. Transplantation 63: 845-848
33. Nakamura, M., Imaoka, S., Miura, K., Tanaka, E., Misawa, S., Funae, Y. (1994) Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporine A. Biochem. Pharmacol. 48: 1743-1746
34. Nash, T. (1953) The calorimetric estimation of formaldehyde by means of the Hantzche reaction. Biochem. J. 55: 416-421
35. Ochiai, T., Nakajima, K., Nagata, M., Suzuki, T., Asano, T., Uematsu, T., Goto, T., Hori, S., Kenmochi, T., Nakagoori, T. (1987) Effect of a new immunosuppressive agent, FK-506, on heterotropic cardiac allotransplantation in allotransplantation in the rat. Transplant. Proc. 19: 1284-1286
36. Ogita, K., Kusunose, E., Ichihara, K., Kusunose, M. (1982) Multiple forms of cytochrome P450 in kidney cortex microsomes of rabbits treated with 3-methylcholanthrene. J. Biochem. 92: 921-928
37. 1 and lauric acid by pig kidney microsomes and purified kidney cytochrome P450. J. Biol. Chem. 256: 5962
38. Omura, T., Sato, R. (1964) The carbon monoxide binding pigment of liver microsomes. J. Biol. Chem. 239: 2379-2385
39. Pichard, L., Fabre, J. M., Domergue, J., Fabre, G., Saint-Aubert, B., Mourad, G., Maurel, P. (1991) Molecular mechanism of cyclosporine A drug interactions: inducers and inhibitors of cytochrome P450 screening in primary cultures of human hepatocytes. Transplant. Proc. 23: 978-979
40. Pichard, L., Domergue, J., Fourtanier, G., Koch, P., Schran, H. F., Maurel, P. (1996) Metabolism of the new immunosuppressor cyclosporin G by human liver cytochrome P450. Biochem. Pharmacol. 51: 591-598
41. Platz, K. P., Sollinger, H. W., Hullett, D. A., Eckhoff, D. E., Eugui, E. M., Allison, A. C. (1991) RS-61443 - a new, potent immunosuppressive agent. Transplantation 51: O27-O31
42. Pratschke, J., Neuhaus, R., Tullius, S. G., Haller, G. W., Jonas, S., Steinmueller, T., Bechstein, W.-O., Neuhaus, P. (1997) Treatment of cyclosporine-related adverse effects by conversion to tacrolimus after liver transplantation. Transplantation 64: 938-940
43. Sattler, M., Guengerich, F. P., Yun, C. H., Christians, U., Sewing, K. F. (1992) Cytochrome P450 3A enzymes are responsible for biotransformation of FK-506 and rapamycin in man and rat. Drug. Metab. Dispos. 20: 753-761
44. Shaw, P. M., Barnes, T. S., Cameron, D., Engeset, J., Melvin, W. T., Omar, G., Petrie, J. C., Rush, W. R., Snyder, C. P., Whiting, P. H. (1989) Purification and characterization of anticonvulsant-induced human cytochrome P450 catalysing cyclosporine metabolism. Biochem. J. 263: 653-663
45. Siekierka, J. J., Hung, S. H., Poe, M., Lin, C. S., Sigal, N. H. (1989) A cytosolic binding protein for the immunosuppressant FK-506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 341: 755-757
46. Solders, G., Wilczek, H., Gunnarsson, R., Tyd'en, G., Persson, A., Groth, C. G. (1987) Effects of combined pancreatic and renal transplantation on diabetic neuropathy: a two-year follow-up study. Lancet 2: 1232-1235
47. Stepkowski, S. M., Chen, H., Daloze, P., Kahan, B. D. (1991) Rapamycin, a potent immunoppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat. Transplantation 51: O22-O26
48. Todo, S., Demetris, A. J., Ueda, Y., Imventarza, O., Okuda, K., Casavilla, A., Cemaj, S., Ghalab, A., Mazzaferro, V., Rhoe, B. S. (1987) Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. Transplant. Proc. 19: 57-61
49. Vincent, S. H., Wang, R. W., Karanam, B. V., Klimko, M., Alvaro, R., Chiu, S.-H. (1991) Effects of the immunosuppressant FK-506 and its analog FK-520 on hepatic and renal cytochrome P450 mixed-function oxidase. Biochem. Pharmacol. 41: 1325-1330
50. Watkins, P. B. (1990) The role of cytochromes P450 in cyclosporine metabolism. J. Am. Acad. Dermatol. 23: 1301-1309
51. Watkins, P. B. (1996) Erythromycin breath test and clinical transplantation. Ther. Drug. Monit. 18: 368-371
52. Yamamoto, S., Kusunose, E., Kaku, M., Ichihara, K., Kusunose, M. (1986) Effect of peroxisomal proliferators on microsomal prostaglandin A hydroxylase. J. Biochem. 100: 1449-1455
53. Yoshimoto, M., Kusunose, E., Yamamoto, S., Maekawa, M., Kusunose, M. (1986) Purification and characterization of two forms of cytochrome P450 from rat kidney cortex microsomes. Biochem. Int. 13: 749-755
54. Yoshimura, R., Yoshimura, N., Kusunose, E., Nakatani, T., Maekawa, M. (1989) Role of kidney microsomal cytochrome P450 in cyclosporin-induced nephropathy. Transplant. Proc. 21: 934
55. Zhou, L. X., Pihlstrom, B., Hardwick, J. P., Park, S. S., Wrighton, S. A., Holtzman, J. L. (1996) Metabolism of phenytoin by the gingiva of normal humans: the possible role of reactive metabolites of phenytoin in the initiation of gingival hyperplasia. Clin. Pharmacol. Ther. 60: 191-198