Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells

International Journal of Molecular Medicine

Volumn 20, Issue 4, 2007, Pages 511-519

  Nomura, Naoko ^a,b   Nomura, Motohiro ^c   Sugiyama, Kazuhisa ^a   Hamada, Jun Ichiro ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c YOKOHAMA SAKAE KYOSAI HOSPITAL   (Japan)

Author keywords

Glioblastoma; Migration; PMA; Protein kinase C; Src

Indexed keywords

ACTIN; CRK ASSOCIATED SUBSTRATE PROTEIN; ONCOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOTYROSINE; PROTEIN KINASE C; PROTEIN KINASE P60; RAC1 PROTEIN;

ARTICLE; CELL MEMBRANE; CELL MOTION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; FOCAL ADHESION; GLIOBLASTOMA; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; PSEUDOPODIUM; SIGNAL TRANSDUCTION;

ACTINS; CELL MEMBRANE; CELL MOVEMENT; CRK-ASSOCIATED SUBSTRATE PROTEIN; ENZYME ACTIVATION; FOCAL ADHESIONS; GLIOBLASTOMA; PHOSPHOTYROSINE; PROTEIN KINASE C; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-CRK; PROTO-ONCOGENE PROTEINS PP60(C-SRC); PSEUDOPODIA; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

EID: 38449123194     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.20.4.511     Document Type: Article

References (40)

1. Berens ME and Giese A: "...those left behind." Biology and oncology of invasive glioma cells. Neoplasia 1: 208-219, 1999.
2. da Rocha AB, Mans DR, Regner A and Schwartsman G: Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? Oncologist 7: 17-33, 2002.
3. Bredel M and Pollack IF: The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to antiglioma therapy. Acta Neurochir 139: 1000-1013, 1997.
4. Sharif TR and Sharif M: Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples. Int J Oncol 5: 237-243, 1999.
5. Cary LA, Klinghoffer RA, Sachsenmaier C and Cooper JA: SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading. Mol Cell Biol 22: 2427-2440, 2002.
6. Fincham VJ and Frame MC: The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J 17: 81-92, 1998.
7. Matsuda M, Mayer BJ, Fukui Y and Hanafusa H: Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science 248: 1537-1539, 1990.
8. Bouton AH, Riggins RB and Bruce-Staskal PJ: Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. Oncogene 20: 6448-6458, 2001.
9. Klemke RL, Leng J, Molander R, Brooks PC, Vuori K and Cheresh DA: CAS/Crk coupling serves as a 'molecular switch' for induction of cell migration. J Cell Biol 140: 961-972, 1998.
10. Burridge K and Wennerberg K: Rho and Rac take center stage. Cell 116: 167-179, 2004.
11. Kraynov VS, Chamberlain C, Bokoch GM, Schwartz MA, Slabaugh S and Hahn KM: Localized Rac activation dynamics visualized in living cells. Science 290: 333-337, 2000.
12. Nomura M, Nomura N and Yamashita J: Geldanamycin-induced degradation of Chk1 is mediated by proteasome. Biochem Biophys Res Commun 335: 900-905, 2005.
13. Brandt DT, Goerke A, Heuer M, et al: Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem 278: 34073-34078, 2003.
14. Fincham VJ, Brunton VG and Frame MC: The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase. Mol Cell Biol 20: 6518-6536, 2000.
15. Hamasaki K, Mimura T, Morino N, et al: Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas. Biochem Biophys Res Commun 222: 338-343, 1996.
16. Sakai R, Iwamatsu A, Hirano N, et al: A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J 13: 3748-3756, 1994.
17. Cherersh DA, Leng J and Klemke RL: Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J Cell Biol 146: 1107-1116, 1999.
18. Cho SY and Klemke RL: Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol 156: 725-736, 2002.
19. Bruce-Staskal and Bouton AH: PKC-dependent activation of FAK and src induces tyrosine phosphorylation of Cas and formation of Cas-Crk complexes. Exp Cell Res 264: 296-306, 2001.
20. Rottner K, Hall A and Small JV: Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol 9: 640-648, 1999.
21. Abassi YA and Vuori K: Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. EMBO J 21: 4571-4582, 2002.
22. Hashimoto Y, Katayama H, Kiyokawa E, et al: Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor. J Biol Chem 273: 17186-17191, 1998.
23. del Pozo MA, Vicente-Manazanares M, Tejedor R, Serrador JM and Sanchez-Madrid F: Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur J Immunol 29: 3609-3620, 1999.
24. Playford MP and Schaller MD: The interplay between Src and integrins in normal and tumor biology. Oncogene 23: 7928-7946, 2004.
25. Schlaepfer DD, Jones KC and Hunter T: Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol 18: 2571-2585, 1998.
26. Xian W, Rosenberg MP and Di Giovanni J: Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion. Oncogene 14: 1435-1444, 1997.
27. Nakamoto T, Sakai R, Ozawa K, Yazaki Y and Hirai H: Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase. J Biol Chem 271: 8959-8965, 1996.
28. Klinghoffer RA, Sachsenmier C, Cooper JA and Soriano P: Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18: 2459-2471, 1999.
29. Caloca MJ, Wang H and Kazanietz MG: Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. Biochem J 375: 313-321, 2003.
30. You HJ, Woo CH, Choi EY, Cho SH, Yoo YJ and Kim JH: Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A2 in response to PMA. Biochem J 388: 527-535, 2005.
31. Zhu T, Goh EL, LeRoith D and Lobie PE: Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK). J Biol Chem 273: 33864-33875, 1998.
32. Cheng CH, Yu KC, Chen HL, et al: Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas). FEBS Lett 557: 221-227, 2004.
33. Chodniewicz D and Klemke RL: Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim Biophys Acta 1692: 63-76, 2004.
34. Ron D and Kazanietz MG: New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13: 1658-1676, 1999.
35. Brandt D, Gimona M, Hillmann M, Haller H and Mischak H: Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway. J Biol Chem 277: 20903-20910, 2002.
36. Nomura N, Nomura M, Sugiyama K and Hamada J: Phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells is mediated via p38MAPK/Hsp27 pathway. Biochem Pharmacol (In press).
37. McMulluen M, Keller R, Sussman M and Pumiqlia K: Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2. Oncogene 23: 1275-1282, 2004.
38. Nagao M, Yamauchi J, Kaziro Y and Itoh H: Involvement of protein kinase C and Src family tyrosine kinase in Galphaq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. J Biol Chem 273: 22892-22898, 1998.
39. Buchsbaum RJ, Connolly BA and Feig LA: Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Mol Cell Biol 22: 4073-4085, 2002.
40. Baldassa S, Gnesutta N, Fascio U, Sturani E and Zippel R: SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth. J Biol Chem 282: 2333-2345, 2007.