PKC-dependent activation of FAK and Src induces tyrosine phosphorylation of Cas and formation of Cas-Crk complexes

Experimental Cell Research

Volumn 264, Issue 2, 2001, Pages 296-306

  Bruce Staskal, Pamela J ^a   Bouton, Amy H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cas; Crk; FAK; PKC; PTK; SH SY5Y; Src; Tyrosine phosphorylation

Indexed keywords

ACTIN; ADAPTOR PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CYTOSKELETON PROTEIN; PROTEIN CRK; PROTEIN KINASE C; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 0035298098     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5137     Document Type: Article

References (82)

1. Phenotypic changes of human neuroblastoma cells in culture induced by TPA
2. Kinetics and concentration effects of TPA-induced differentiation of cultured neuroblastoma cells
3. SRC kinase activity during neuronal differentiation of cultured human neuroblastoma cells
4. Regulation of protein kinase C
5. Novel and classical protein kinase C isoforms have different functions in proliferation, survival, and differentiation of neuroblastoma cells
6. Cas in differentiating neuroblastoma cells
7. Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
8. Cas) are elevated in cytoskeleton-associated fractions following adhesion and cell transformation
9. Requirements for localization of p130(Cas) to focal adhesions
10. Role of tyrosine phosphorylation in matrix-induced neurite outgrowth in human neuroblastoma cells
11. K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells
12. Tyrosine phosphorylation and enhanced expression of paxillin during neural differentiation in vitro
13. Tyrosine phosphorylation of paxillin and focal adhesion kinase during IGF-I stimulate lamellipodial advance
14. A novel signaling molecule, p130, forms stable complexes in vivo with v-CRK and v-SRC in a tyrosine phosphorylation-dependent manner
15. Cas
16. Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix
17. Cas to SH2 and SH3 domains of Src kinase
18. Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs
19. Cas to the guanine nucleotide exchange factor C3G
20. Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate
21. Cas, and Nck adaptor proteins
22. Tyrosine phosphorylation of CRK-associated substrates by focal adhesion kinase
23. Cas
24. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
25. FAK
26. FAK
27. Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: A role for paxillin tyrosine phosphorylation
28. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
29. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases
30. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes
31. Pyk2 and FAK regulate neurite outgrowth induced by growth factors ad integrins
32. Src family kinases are required for integrin but not PDGFR signal transduction
33. Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton
34. Monoclonal antibodies to individual tyrosine phosphorylated substrates of oncogene-encoded tyrosine kinases
35. Integrin signaling and tyrosine phosphorylation: Just the FAKS?
36. Transformation by a temperature-sensitive mutant of Rous sarcoma virus in the absence of serum
37. Use of an oriented peptide library to determine the optimal substrate of protein kinases
38. SH2 domains recognize specific phosphopeptide sequences
39. Cas binding proteins and their role in cellular transformation
40. Cas with CRK and GRB2 adaptor proteins
41. Cas in PC12 cells
42. Cas/CRK coupling serves as a "molecular switch" for induction of cell migration
43. A novel viral oncogene with structural similarity to phospholipase C
44. Both the SH2 and SH3 domains of human CRK proteins are required for neuronal differentiation of PC12 cells
45. CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells
46. Downstream of Crk adaptor signaling pathway: Activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G
47. Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by expression of Crk, CrkL, and Grb2
48. Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein
49. Evidence that DOCK180 up-regulates signals from the CRK-II-Cas complex
50. Cas by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor
51. Cas, focal adhesion kinase, and paxillin
52. Cas tyrosine phosphorylation, translocation, and association with Crk in rat pancreatic acinar cells
53. Cas/Crk signaling mediates uptake of Yersinia into human epithelial cells
54. Cas using a panel of monoclonal antibodies
55. The role of Src-Cas interactions in cellular transformation: Ectopic expression of the carboxy terminus of Cas inhibits Src-Cas interaction but has no effect on cellular transformation
56. CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells
57. Immunoaffinity purification of tyrosine-phosphorylated cellular proteins
58. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
59. Cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
60. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
61. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go6976
62. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimdes
63. Src at a novel site
64. src with two tyrosine-phosphorylated cellular proteins
65. src direct stable association with tyrosine phosphorylated p130 and p110
66. Cytoskeletal and phosphoinositide requirements for muscarinic receptor signaling to focal adhesion kinase and paxillin
67. Integrin-mediated signalling: Regulation by protein tyrosine kinases and small GTP-binding proteins
68. Rho GTPases and the actin cytoskeleton
69. Actin cytoskelton organization in response to integrin-mediated adhesion
70. Integrin signalling: A new Cas(t) of characters enters the stage
71. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
72. HEF1, a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated in ligation of integrin or antigen receptor on human B cells
73. Cas
74. Cas and c-CRK-II by ANG II in vascular smooth muscle cells
75. Growth hormone stimulates the formation of a multiprotein signaling complex involving p130Cas and Crk II
76. Extracellular-regulated kinase activation and Cas/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
77. PKCε, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells
78. Protein kinase C-ε is implicated in neurite outgrowth in differentiating human neuroblastoma cells
79. v-src1
80. Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro
81. Accelerated degradation of 160 kDa epidermal growth factor (EGF) receptor precursor by the tyrosine kinase inhibitor herbimycin A in the endocytoplasmic reticulum of A431 human epidermoid carcinoma cells
82. Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors