Parathyroid hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic adenosine 3′,5′-monophosphate signaling in osteoblasts

Endocrinology

Volumn 145, Issue 8, 2004, Pages 3696-3703

  Ozkurt, Ibrahim C ^a   Pirih, Flavia Q ^a   Tetradis, Sotirios ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; BINDING PROTEIN; CALCIUM ION; CALCIUM IONOPHORE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP DERIVATIVE; E4 PROMOTER BINDING PROTEIN; FLUPROSTENOL; FORSKOLIN; IONOMYCIN; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PARATHYROID HORMONE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE[1-34]; PARATHYROID HORMONE[3-34]; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM SIGNALING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; DNA-BINDING PROTEINS; G-BOX BINDING FACTORS; GENE EXPRESSION REGULATION; MICE; OSTEOBLASTS; PARATHYROID HORMONE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 3843052410     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1436     Document Type: Article

References (65)

1. Juppner H 1999 Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance. Bone 25:87-90
2. Swarthout JT, D'Alonzo RC, Selvamurugan N, Partridge NC 2002 Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene 282:1-17
3. Henderson JE, Kremer R, Rhim JS, Goltzman D 1992 Identification and functional characterization of adenylate cyclase-linked receptors for parathyroid hormone-like peptides on immortalized human keratinocytes. Endocrinology 130:449-457
4. Gardella TJ, Juppner H 2001 Molecular properties of the PTH/PTHrP receptor. Trends Endocrinol Metab 12:210-217
5. Partridge NC, Bloch SR, Pearman AT 1994 Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression. J Cell Biochem 55:321-327
6. Miles RR, Sluka JP, Halladay DL, Santerre RF, Hale LV, Bloem L, Patanjali SR, Galvin RJ, Ma L, Hock JM, Onyia JE 2002 Parathyroid hormone (hPTH 1-38) stimulates the expression of UBP41, an ubiquitin-specific protease, in bone. J Cell Biochem 85:229-242
7. Miles RR, Sluka JP, Halladay DL, Santerre RF, Hale LV, Bloem L, Thirunavukkarasu K, Galvin RJ, Hock JM, Onyia JE 2000 ADAMTS-1: a cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone. Endocrinology 141:4533-4542
8. Miles RR, Sluka JP, Santerre RF, Hale LV, Bloem L, Boguslawski G, Thirunavukkarasu K, Hock JM, Onyia JE 2000 Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms. Endocrinology 141:28-36
9. Onyia JE, Miles RR, Yang X, Halladay DL, Hale J, Glasebrook A, McClure D, Seno G, Churgay L, Chandrasekhar S, Martin TJ 2000 In vivo demonstration that human parathyroid hormone 1-38 inhibits the expression of osteoprotegerin in bone with the kinetics of an immediate early gene. J Bone Miner Res 15:863-871
10. Fujimori A, Cheng SL, Avioli LV, Civitelli R 1992 Structure-function relationship of parathyroid hormone: activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells. Endocrinology 130:29-36
11. Herschman HR 1991 Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 60:281-319
12. McMahon SB, Monroe JG 1992 Role of primary response genes in generating cellular responses to growth factors. FASEB J 6:2707-2715
13. Clohisy JC, Scott DK, Brakenhoff KD, Quinn CO, Partridge NC 1992 Parathyroid hormone induces c-fos and c-jun messenger RNA in rat osteoblastic cells. Mol Endocrinol 6:1834-1842
14. Tsingotjidou A, Nervina JM, Pham L, Bezouglaia O, Tetradis S 2002 Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3′,5′-monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone 30:677-684
15. Doggett TA, Swarthout JT, Jefcoat Jr SC, Wilhelm D, Dieckmann A, Angel P, Partridge NC 2002 Parathyroid hormone inhibits c-Jun N-terminal kinase activity in rat osteoblastic cells by a protein kinase A-dependent pathway. Endocrinology 143:1880-1888
16. Tetradis S, Bezouglaia O, Tsingotjidou A 2001 Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells. Endocrinology 142:663-670
17. Tetradis S, Bezouglaia O, Tsingotjidou A, Vila A 2001 Regulation of the nuclear orphan receptor Nur77 in bone by parathyroid hormone. Biochem Biophys Res Commun 281:913-916
18. Greenfield EM, Horowitz MC, Lavish SA 1996 Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction. J Biol Chem 271:10984-10989
19. Nervina JM, Tetradis S, Huang YF, Harrison D, Molina C, Kream BE 2003 Expression of inducible cAMP early repressor is coupled to the cAMP-protein kinase A signaling pathway in osteoblasts. Bone 32:483-490
20. Pirih FQ, Nervina JM, Pham L, Aghaloo T, Tetradis S 2003 Parathyroid hormone induces the nuclear orphan receptor NOR-1 in osteoblasts. Biochem Biophys Res Commun 306:144-150
21. Ozkurt IC, Tetradis S 2003 Parathyroid hormone-induced E4BP4/NFIL3 downregulates transcription in osteoblasts. J Biol Chem 278:26803-26809
22. Cowell IG, Skinner A, Hurst HC 1992 Transcriptional repression by a novel member of the bZIP family of transcription factors. Mol Cell Biol 12:3070-3077
23. Blackshear PJ, Witters LA, Girard PR, Kuo JF, Quamo SN 1985 Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways. J Biol Chem 260:13304-13315
24. Gardella TJ, Axelrod D, Rubin D, Keutmann HT, Potts Jr JT, Kronenberg HM, Nussbaum SR 1991 Mutational analysis of the receptor-activating region of human parathyroid hormone. J Biol Chem 266:13141-13146
25. Aubin JE 2001 Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2:81-94
26. Liu F, Malaval L, Aubin JE 2003 Global amplification polymerase chain reaction reveals novel transitional stages during osteoprogenitor differentiation. J Cell Sci 116:1787-1796
27. Zhao Q, Brauer PR, Xiao L, McGuire MH, Yee JA 2002 Expression of parathyroid hormone-related peptide (PthrP) and its receptor (PTH1R) during the histogenesis of cartilage and bone in the chicken mandibular process. J Anat 201:137-151
28. Rosen CJ 2003 The cellular and clinical parameters of anabolic therapy for osteoporosis. Crit Rev Eukaryot Gene Expr 13:25-38
29. Iida-Klein A, Zhou H, Lu SS, Levine LR, Ducayen-Knowles M, Dempster DW, Nieves J, Lindsay R 2002 Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice. J Bone Miner Res 17:808-816
30. Locklin RM, Khosla S, Turner RT, Riggs BL 2003 Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone. J Cell Biochem 89:180-190
31. Rubin MR, Bilezikian JP 2003 New anabolic therapies in osteoporosis. Endocrinol Metab Clin North Am 32:285-307
32. D'Alonzo RC, Selvamurugan N, Karsenty G, Partridge NC 2002 Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem 277:816-822
33. Krishnan V, Moore TL, Ma YL, Helvering LM, Frolik CA, Valasek KM, Ducy P, Geiser AG 2003 Parathyroid hormone bone anabolic action requires cbfa1/ runx2-dependent signaling. Mol Endocrinol 17:423-435
34. Qin L, Qiu P, Wang L, Li X, Swarthout JT, Soteropoulos P, Tolias P, Partridge NC 2003 Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics. J Biol Chem 278:19723-19731
35. Dossing DA, Radeff JM, Sanders J, Lee SK, Hsieh MR, Stern PH 2001 Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells. Bone 29:223-230
36. Miao D, Tong XK, Chan GK, Panda D, McPherson PS, Goltzman D 2001 Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem 276:32204-32213
37. Kawane T, Mimura J, Yanagawa T, Fujii-Kuriyama Y, Horiuchi N, Chin KV, Yang WL, Ravatn R, Kita T, Reitman E, Vettori D, Cvijic ME, Shin M, Iacono L 2003 Parathyroid hormone (PTH) down-regulates PTH/PTH-related protein receptor gene expression in UMR-106 osteoblast-like cells via a 3′,5′-cyclic adenosine monophosphate-dependent, protein kinase A-independent pathway. J Endocrinol 178:247-256
38. Chin KV, Yang WL, Ravatn R, Kita T, Reitman E, Vettori D, Cvijic ME, Shin M, Iacono L 2002 Reinventing the wheel of cyclic AMP: novel mechanisms of cAMP signaling. Ann NY Acad Sci 968:49-64
39. Fujimori A, Cheng SL, Avioli LV, Civitelli R 1991 Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells. Endocrinology 128:3032-3039
40. Coleman RA, Smith WL, Narumiya S 1994 International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46:205-229
41. Ashby B 1998 Co-expression of prostaglandin receptors with opposite effects: a model for homeostatic control of autocrine and paracrine signaling. Biochem Pharmacol 55:239-246
42. Negishi M, Sugimoto Y, Ichikawa A 1995 Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1259:109-119
43. Breyer RM, Bagdassarian CK, Myers SA, Breyer MD 2001 Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 41:661-690
44. Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R 1994 Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem 269:2632-2636
45. 2 receptor EP2 subtype. J Biol Chem 269:11873-11877
46. 2α receptor. J Biol Chem 269:3881-3886
47. Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD 1995 Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. Mol Cell Biol 15:6055-6063
48. Nishimura Y, Tanaka T 2001 Calcium-dependent activation of nuclear factor regulated by interleukin 3/adenovirus E4 promoter-binding protein gene expression by calcineurin/nuclear factor of activated T cells and calcium/ calmodulin-dependent protein kinase signaling. J Biol Chem 276:19921-19928
49. Wallace AD, Wheeler TT, Young DA 1997 Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids. Biochem Biophys Res Commun 232:403-406
50. Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT 1997 Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc Natl Acad Sci USA 94: 2609-2614
51. Chu CC, Paul WE 1998 Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol 35:487-502
52. Yu YL, Chiang YJ, Yen JJ 2002 GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells. J Biol Chem 277:27144-27153
53. Kuribara R, Kinoshita T, Miyajima A, Shinjyo T, Yoshihara T, Inukai T, Ozawa K, Look AT, Inaba T 1999 Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. Mol Cell Biol 19:2754-2762
54. Unoki M, Nakamura Y 2001 Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene 20:4457-4465
55. Mohan S, Kutilek S, Zhang C, Shen HG, Kodama Y, Srivastava AK, Wergedal JE, Beamer WG, Baylink DJ 2000 Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice. Bone 27:471-478
56. Alexander JM, Bab I, Fish S, Muller R, Uchiyama T, Gronowicz G, Nahounou M, Zhao Q, White DW, Chorev M, Gazit D, Rosenblatt M 2001 Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice. J Bone Miner Res 16:1665-1673
57. Kitahara K, Ishijima M, Rittling SR, Tsuji K, Kurosawa H, Nifuji A, Denhardt DT, Noda M 2003 Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation. Endocrinology 144: 2132-2140
58. Newman JR, Keating AE 2003 Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science 300:2097-2101
59. Stanislaus D, Devanarayan V, Hock JM 2000 In vivo comparison of activated protein-1 gene activation in response to human parathyroid hormone (hPTH)(1-34) and hPTH(1-84) in the distal femur metaphyses of young mice. Bone 27:819-826
60. McCauley LK, Koh-Paige AJ, Chen H, Chen C, Ontiveros C, Irwin R, McCabe LR 2001 Parathyroid hormone stimulates fra-2 expression in osteoblastic cells in vitro and in vivo. Endocrinology 142:1975-1981
61. Wagner EF 2002 Functions of AP1 (Fos/Jun) in bone development. Ann Rheum Dis 61:ii40-ii42
62. Selvamurugan N, Chou WY, Pearman AT, Pulumati MR, Partridge NC 1998 Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence. J Biol Chem 273:10647-10657
63. Fu Q, Jilka RL, Manolagas SC, O'Brien CA 2002 Parathyroid hormone stimulates receptor activator of NFKB ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J Biol Chem 277:48868-48875
64. Tyson DR, Swarthout JT, Jefcoat SC, Partridge NC 2002 PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Endocrinology 143:674-682
65. Tetradis S, Pilbeam CC, Liu Y, Herschman HR, Kream BE 1997 Parathyroid hormone increases prostaglandin G/H synthase-2 transcription by a cyclic adenosine 3′,5′-monophosphate-mediated pathway in murine osteoblastic MC3T3-E1 cells. Endocrinology 138:3594-3600