Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells

Bone

Volumn 29, Issue 3, 2001, Pages 223-230

  Dossing, D A ^a   Radeff, J M ^a   Sanders, J ^a   Lee, S K ^a   Hsieh, M R ^a   Stern, P H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Osteoblast; Parathyroid hormone (PTH); Phorbol dibutyrate; Protein kinase C isozymes; UMR 106

Indexed keywords

ISOENZYME; PARATHYROID HORMONE; PHORBOL DIBUTYRATE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL FRACTIONATION; CELL LYSATE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME LOCALIZATION; HORMONE ACTION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MEMBRANE; NONHUMAN; OSTEOBLAST; OSTEOSARCOMA CELL; PROTEIN TRANSPORT; RAT;

ANIMALS; BONE NEOPLASMS; CARCINOGENS; CELL MEMBRANE; CYTOSOL; ISOENZYMES; OSTEOBLASTS; OSTEOSARCOMA; PARATHYROID HORMONE; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; PROTEIN KINASE C-EPSILON; RATS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0034839934     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00507-5     Document Type: Article

References (39)

1. Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells
2. Enhancement of fetal rat limb bone resorption by phorbol ester (PMA) and ionophore A-23187
3. G-protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes
4. The regulation and cellular functions of phosphatidylcholine hydrolysis
5. Role of protein kinase C (PKC) in bone resorption: Effect of the specific PKC inhibitor 1-alkyl-2-methylglycerol
6. Parathyroid hormone fragment [3-34] stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphocyte cells
7. PTH elevates inositol phosphates and diacylglycerol in a rat osteoblast-like cell line
8. Stimulation of inositol phosphate formation in ROS 17/2.8 cell membranes by guanine nucleotide, calcium and parathyroid hormone
9. Protein kinase C - A question of specificity
10. Signaling through phosphatidylcholine breakdown
11. Structure-function relationship of parathyroid hormone: Activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells
12. +-coupled ion carriers in isolated mammalian kidney epithelial cells: Regulation by protein kinase C
13. Insulin acutely suppresses parathyroid hormone second messenger generation in UMR-106-01 osteoblast-like cells - Differential effects on phospholipase-C and adenylate cyclase activation
14. Protein kinase C activity in UMR-106-01 cells: Effects of parathyroid hormone and insulin
15. The protein kinase-C activation domain of the parathyroid hormone
16. Protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I (GF109203X) have divergent effects on bone resorption
17. Phorbol esters stimulate bone resorption in fetal rat long-bone cultures by mechanisms independent of prostaglandin synthesis
18. Protein measurement with the folin phenol reagent
19. Stimulation of IL-6 promoter by parathyroid hormone, tumor necrosis factor-α, and interleukin-1β in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists
20. Effect of parathyroid hormone on rat renal cAMP-dependent protein kinase and protein kinase C activity measured using synthetic peptide substrates
21. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
22. i cotransporters by PTH
23. Abnormalities of parathyroid hormone-mediated signal transduction mechanisms in opossum kidney cells
24. Protein kinase C-β-selective antagonist LY379196 inhibits resorption of fetal rat limb bones and interleukin-6 promoter expression in UMR-106 cells
25. 12-O-Tetradecanoylphorbol-13-acetate, a phorbol ester stimulating protein kinase C, inhibits bone resorption in vitro induced by parathyroid hormone and parathyroid hormone-related peptide of malignancy
26. Parathyroid hormone and calcitonin modify inositol phospholipid metabolism in fetal rat limb bones
27. Parathyroid hormone acutely elevates intracellular calcium in osteoblastlike cells
28. Expression and phorbol ester-induced downregulation of protein kinase C isozymes in osteoblasts
29. Protein kinase C involvement in interleukin-6 production by parathyroid hormone and tumor necrosis factor-α in UMR-106 osteoblastic cells
30. 34] PTH-(3-34) amide, PTH-(1-31) amide, and PTH-related peptide-(1-34) stimulate phosphatidylcholine hydrolysis in UMR-106 osteoblastic cells: Comparison with effects of phorbol 12,13-dibutyrate
31. Parathyroid hormone-induced calcium efflux from cultured bone is mediated by protein kinase C translocation
32. Calcium/phosphatidylserine-stimulated protein phosphorylation in bone: Effect of parathyroid hormone
33. 34-parathyroid hormone (3-34) amide increase diacylglycerol in neonatal mouse calvaria
34. Parathyroid hormone 1-34, but not 3-34 or 7-34, transiently translocates protein kinase C in cultured renal (OK) cells
35. Stimulation of prostaglandin production in bone by phorbol diesters and melittin
36. U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells
37. i cotransporter
38. Parathyroid hormone-activated calcium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-dependent and cAMP-independent calcium channels
39. Down-regulation of protein kinase C is due to an increased rate of degradation