Parathyroid hormone increases prostaglandin G/H synthase-2 transcription by a cyclic adenosine 3',5'-monophosphate-mediated pathway in murine osteoblastic MC3T3-E1 cells

Endocrinology

Volumn 138, Issue 9, 1997, Pages 3594-3600

  Tetradis, Sotirios ^a,d   Pilbeam, Carol C ^e   Liu, Yong ^e   Herschman, Harvey R ^b   Kream, Barbara E ^c  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d HARVARD INSTITUTES OF MEDICINE   (United States)

^e Harvard Institutes of Medicine ^*

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM IONOPHORE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLOHEXIMIDE; IONOMYCIN; LUCIFERASE; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PARATHYROID HORMONE; PHORBOL ESTER; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; GENE ACTIVATION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0030756167     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.9.5391     Document Type: Article

References (12)

1. Juppner H, Abou-Samra A, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LFJ, Hock J, Potts JTJ, Kronenberg HM, Segre GV 1991 A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1025
2. Fujimori A, Cheng S, Avioli LV, Civitelli R 1992 Structure-function relationship of parathyroid hormone: activation of phopholipase-C, protein kinase-A and -C in osteosarcoma cells. Endocrinology 130:29-36
3. Partridge NC, Bloch SR, Pearman AT 1994 Signal transduction pathways mediating parathyroid homone regulation of osteoblastic gene expression. J Cell Biochem 55:321-327
4. Raisz LG, Simmons HA 1985 Effects of parathyroid hormone and cortisol on prostaglandin production by neonatal rat calvariae in vitro. Endocr Res 11:59-74
5. Klein-Nulend J, Pilbeam CC, Harrison JR, Fall PM, Raisz LG 1991 Mechanism of regulation of prostaglandin production by parathyroid hormone, interleukin-1, and cortisol in culture mouse parietal bones. Endocrinology 128:2503-2510
6. Feyen JHM, van der Will G, Moonen P, Di Bon A, Nijweide PJ 1984 Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells in culture. Prostaglandins 28:769-781
7. 2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor I. Endocrinology 133:1504-1510
8. Raisz LG, Fall PM, Petersen DN, Lichtler A, Kream BE 1993 Prostaglandin E2 inhibits alphal(I) procollagen gene transcription and promoter activity in the immortalized rat osteoblastic clonal cell line Pyla. Mol Endocrinol 7:17-22
9. Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG 1995 The role of prostaglandins in the regulation of bone metabolism. Clin Orthop 313:36-46
10. Kujubu DA, Fletcher BS, Vamum BC, Lim RW, Herschman HR 1991 TIS 10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266:12866-12872
11. Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL 1991 Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 88:2692-2696
12. Herschman HR 1995 Prostaglandin synthase 2. Biochim Biophys Acta 1299:125-140