Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma

Digestive Diseases and Sciences

Volumn 48, Issue 3, 2003, Pages 459-464

  Xie, Min Jue ^a,b   Motoo, Yoshiharu ^a   Iovanna, Juan Lucio ^b   Su, Shi Bing ^a   Ohtsubo, Koushiro ^a   Matsubara, Fujitsugu ^c   Sawabu, Norio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b INSERM   (France)

^c Houju Memorial Hospital   (Japan)

Author keywords

Immunohistochemistry; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatitis associated protein; Tumor aggressiveness

Indexed keywords

MESSENGER RNA; PANCREATITIS ASSOCIATED PROTEIN;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHRONIC PANCREATITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTADENOCARCINOMA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; CARCINOMA, PANCREATIC DUCTAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LECTINS, C-TYPE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PANCREATIC NEOPLASMS; PROPORTIONAL HAZARDS MODELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0037341953     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022520212447     Document Type: Article

References (26)

1. Keim V, Iovanna JL, Dagorn JC: The acute phase reaction of the exocrine pancreas: gene expression and synthesis of pancreatitis-associated proteins. Digestion 55:65-72, 1994
2. Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL: Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. Genomics 19:108-114, 1994
3. Su SB, Motoo Y, Xie MJ, Sakai J, Taga H, Sawabu N: Expression of pancreatitis-associated protein (PAP) in rat spontaneous chronic pancreatitis: effect of herbal medicine Saiko-keishi-to (TJ-10). Pancreas 19:239-247, 1999
4. Iovanna JL, Keim V, Nordback I, Montalto G, Camarena J, Letoublon C, Lévy P, Berthézène P, Dagorn JC: Serum levels of pancreatitis associated protein as indicators of the course of acute pancreatitis. Gastroenterology 106:728-734, 1994
5. Sarles J, Barthelèmy-Bialas S, Ferec C, Iovanna JL, Roussey M, Farriaux JP, Toutain A, Berthelot J, Maurin N, Codet JP, Berthézène P, Dagorn JC: Blood concentration of pancreatitis associated protein in neonates: relevance to neonatal screening for cystic fibrosis. Arch Dis Child Fetal Neonatal Ed 80:F118-F122, 1999
6. Ortiz EM, Dusetti NJ, Vasseur S, Malka D, Bödeker H, Dagorn JC, Iovanna JL: The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis. Gastroenterology 114:808-816, 1998
7. Heller A, Fiedler F, Schmeck J, Lück V, Med C, Iovanna JL, Koch T: Pancreatitis-associated protein protects the lung from leukocyte-induced injury. Anesthesiology 91:1408-1414, 1999
8. Dusetti NJ, Ortiz EM, Mallo GV, Dagorn JC, Iovanna JL: Pancreatitis associated protein I (PAP I), an acute phase protein induced by cytokines: identification of two functional interleukin-6 response elements in the rat PAP I promoter region. J Biol Chem 270:22417-22421, 1995
9. Iovanna JL, Keim V, Bosshard A, Orelle B, Frigerio JM, Dusetti N, Dagorn JC: PAP, a pancreatic secretory protein induced during acute pancreatitis, is expressed in rat intestine. Am J Physiol 265:G611-G618, 1993
10. Carroccio A, Iovanna JL, Iacono G, Li Pani M, Montalto G, Cavataio F, Marasà L, Barthelémy-Bialas S, Dagorn JC: Pancreatitis-associated protein in patients with celiac disease: serum levels and immunocytochemical localization in small intestine. Digestion 58:98-103, 1997
11. Lasserre C, Christa L, Simon MT, Vernier P, Bréchot C: A novel gene (HIP) activated in human primary liver cancer. Cancer Res 52:5089-5095, 1992
12. Dusetti NJ, Montalto G, Ortiz EM, Masciotra L, Dagorn JC, Iovanna JL: Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications. Br J Cancer 74:1767-1775, 1996
13. Montalto G, Iovanna JL, Soresi M, Dusetti N, Carroccio A, Barthelémy-Bialas S, Cartabellotta A, Dagorn JC: Clinical evaluation of pancreatitis-associated protein as a serum marker of hepatocellular carcinoma: comparison with alpha-fetoprotein. Oncology 55:421-425, 1998
14. Steinberg WM, Gelfand R, Anderson KK, Glenn J, Kurtzman SH, Sindelar WF, Toskes PP: Comparison of the sensitivity and specificity of the CA19-9 and carcinoembryonic antigen assays in detecting cancer of the pancreas. Gastroenterology 90:343-349, 1986
15. Motoo Y, Itoh T, Su SB, Nakatani MT, Watanabe H, Okai T, Sawabu N: Expression of pancreatitis associated protein (PAP) mRNA in gastrointestinal cancers. Int J Pancreatol 23:11-16, 1998
16. Motoo Y, Satomura Y, Mouri H, Ohtsubo K, Sakai J, Fujii T, Taga H, Yamaguchi Y, Watanabe H, Okai T, Sawabu N: Serum levels of pancreatitis associated protein in digestive diseases with special reference to gastrointestinal cancers. Dig Dis Sci 44:1141-1147, 1999
17. Motoo Y, Watanabe H, Yamaguchi Y, Xie MJ, Mouri H, Ohtsubo K, Okai T, Wakabayashi T, Sawabu N: Pancreatitis-associated protein levels in pancreatic juice from patients with pancreatic diseases. Pancreatology 1:43-47, 2001
18. Cerwenka H, Aigner R, Bacher H, Werkgartner G, El-Shabrawi A, Quehenberger F, Mischinger HJ: Pancreatitis-associated protein (PAP) in patients with pancreatic cancer. Anticancer Res 21:1471-1474, 2001
19. Orelle B, Keim V, Masciotra L, Iovanna JL: Human pancreatitis-associated protein: messenger RNA cloning and expression in pancreatic diseases. J Clin Invest 90:2284-2291, 1992
20. Klöppel G: Pancreatic non-endocrine tumors. In G Klöppel (ed). Pancreatic Pathology. Edinburgh, Scotland: Churchill Livingston, 1984, pp 79-113
21. Hermreck AS, Thomas CY, Friesen SR: Importance of pathologic staging in the surgical management of adenocarcinoma of the exocrine pancreas. Am J Surg 85:653-657, 1974
22. Itoh T, Sawabu N, Motoo Y, Funakoshi A, Teraoka H: The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5′ exons. Gene 155:283-287, 1995
23. Rosty C, Christa L, Kuzdzal S, Baldwin WM, Zahurak ML, Carnot F, Chan DW, Canto M, Lillemoe KD, Cameron JL, Yeo CJ, Hruban RH, Goggins M: Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res 62:1868-1875, 2002
24. Malka D, Vasseur S, Bödeker H, Ortiz EM, Dusetti NJ, Verrando P, Dagorn JC, Iovanna JL: Tumor necrosis factor α triggers anti-apoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation. Gastroenterology 119:816-828, 2000
25. Valery C, Vasseur S, Sabatier F, Iovanna JL, Dagorn JC, Grob JJ, Verrando P: Pancreatitis associated protein I (PAP-I) alters adhesion and motility of human melanocytes and melanoma cells. J Invest Dermatol 116:426-433, 2001
26. Frankfurt OS, Robb JA, Sugarbaker EV, Villa L: Apoptosis in breast carcinomas detected with monoclonal antibody to single-stranded DNA: relation to bcl-2 expression, hormone receptors, and lymph node metastases. Clin Cancer Res 3:465-471, 1997