Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas

International Journal of Cancer

Volumn 103, Issue 2, 2003, Pages 185-193

  Violette, Sabine ^a   Festor, Estelle ^a   Pandrea Vasile, Ivona ^c   Mitchell, Valërie ^a   Adida, Colette ^a,b   Dussaulx, Elisabeth ^a   Lacorte, Jean Marc ^a,b   Chambaz, Jean ^a,b   Lacasa, Michel ^a   Lesuffleur, Thécla ^a  

^a INSERM   (France)

^b HÔTEL DIEU   (France)

^c Hôtel Dieu ^*

Author keywords

Cell survival; Colon cancer cells; Colorectal cancer; Drug resistance; Reg IV

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ANTINEOPLASTIC AGENT; CALCINEURIN; CATHEPSIN H; CHAPERONIN; COMPLEMENTARY DNA; COMPLEMENTARY RNA; CYTOCHROME C OXIDASE; FLUOROURACIL; MESSENGER RNA; METHOTREXATE; PLECKSTRIN; PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; DRUG SENSITIVITY; ENZYME SUBUNIT; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MULTIDRUG RESISTANCE; MULTIGENE FAMILY; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGENERATING IV GENE; RNA PROBE;

ADENOCARCINOMA; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BLOTTING, NORTHERN; CALCIUM-BINDING PROTEINS; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; LECTINS, C-TYPE; LITHOSTATHINE; MALE; MULTIGENE FAMILY; NEOPLASM STAGING; NERVE TISSUE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PROBES; RNA, MESSENGER; RNA, NEOPLASM; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0037427784     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10788     Document Type: Article

References (47)

1. Gorlick R, Bertino JR. Drug resistance in colon cancer. Semin Oncol 1999;26:606-11.
2. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
3. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70.
4. Kinsella AR, Smith D, Pickard M. Resistance to chemotherapeutic antimetabolites: A function of salvage pathway involvement and cellular response to DNA damage. Br J Cancer 1997;75:935-45.
5. Janin N. A simple model for carcinogenesis of colorectal cancers with microsatellite instability. Adv Cancer Res 2000;77:189-221.
6. McCurrach ME, Connor TM, Knudson CM, Korsmeyer SJ, Lowe SW. bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci USA 1997;94:2345-9.
7. Mirjolet JF, Barberi-Heyob M, Didelot C, Peyrat JP, Abecassis J, Millon R, Merlin JL. Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status. Br J Cancer 2000;83:1380-6.
8. Nita ME, Ono-Nita SK, Tsuno N, Tominaga O, Takenoue T, Sunami E, Kitayama J, Nakamura Y, Nagawa H. Bcl-X(L) antisense sensitizes human colon cancer cell line to 5-fluorouracil. Jpn J Cancer Res 2000;91:825-32
9. Reed JC. Bcl-2 family proteins: Role in dysregulation of apoptosis and chemoresistance. In: Martin SJ. Apoptosis and Cancer, Karger Landes Systems, 1997. 65-97.
10. Hazlehurst LA, Damiano JS, Buyuksal I, Pledger WJ, Dalton WS. Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR). Oncogene 2000;19:4319-27.
11. St Croix B, Kerbel RS. Cell adhesion and drug resistance in cancer. Curr Opin Oncol 1997;9:549-56.
12. Cazin JL, Gosselin P, Cappelaere P, Robert J, Demaille A. Drug resistance in oncology: From concepts to applications. J Cancer Res Clin Oncol 1992;119:76-86.
13. Lesuffleur T, Violette S, Vasile-Pandrea I, Dussaulx E, Barbat A, Muleris M, Zweibaum A. Resistance to high concentrations of methotrexate and 5-fluorouracil of differentiated HT-29 colon-cancer cells is restricted to cells of enterocytic phenotype. Int J Cancer 1998;76:383-92.
14. Tlsty TD. Cell-adhesion-dependent influences on genomic instability and carcinogenesis. Curr Opin Cell Biol 1998;10:647-53.
15. Park CC, Bissell MJ, Barcellos-Hoff MH. The influence of the microenvironment on the malignant phenotype. Mol Med Today 2000;6:324-9.
16. Brambilla E, Moro D, Gazzeri S, Brichon PY, Nagy-Mignotte H, Morel F, Jacrot M, Brambilla C. Cytotoxic chemotherapy induces cell differentiation in small-cell lung carcinoma. J Clin Oncol 1991;9:50-61.
17. Lesuffleur T, Barbat A, Dussaulx E, Zweibaum A. Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells. Cancer Res. 1990;50:6334-43.
18. Lesuffleur T, Barbat A, Luccioni C, Beaumatin J, Claire M, Kornowski A, Dussaulx E, Zweibaum A. Dihydrofolate reductase gene amplification-associated shift of differentiation in methotrexate-adapted HT-29 cells. J Cell Biol 1991a;115:1409-18.
19. Lesuffleur T, Kornowski A, Augeron C, Dussaulx E, Barbat A, Laboisse C, Zweibaum A. Increased growth adaptability to 5-fluorouracil and methotrexate of HT-29 sub-populations selected for their commitment to differentiation. Int J Cancer 1991b;49:731-37.
20. Lesuffleur T, Kornowski A, Luccioni C, Muleris M, Barbat A, Beaumatin J, Dussaulx E, Zweibaum A. Adaptation to 5-fluorouracil of the heterogeneous human colon tumor cell line HT-29 results in the selection of cells committed to differentiation. Int J Cancer 1991;49:721-30.
21. Ho SB, Yah PS, Dahiya R, Neuschwander-Tetri BA, Basbaum C, Kim YS. Stable differentiation of a human colon adenocarcinoma cell line by sodium butyrate is associated with multidrug resistance. J Cell Physiol 1994;160:213-26.
22. Bosch S, Siavoshian S, Jacquot C, Tomasoni C, Dabouis G, Elanbaloussi Y, Leneel T, More MT, Roussakis C. Correlation between multidrug resistance and the degree of differentiation of non-small-cell bronchopulmonary carcinoma (NSCLC) in vitro and in vivo. Anticancer Res 1997;17:4595-8.
23. Peters WHM, Roelofs HMJ. Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: A possible role for glutathione S-transferases. Cancer Res 1992;52:1886-90.
24. Zweibaum A, Pinto M, Chevalier G, Dussaulx E, Triadou N, Lacroix B, Haffen K, Brun JL, Rousset M. Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose. J Cell Physiol 1985;122:21-9.
25. L in addition to Bax and P53 status. Int J Cancer 2002;98:498-504.
26. Liang P, Pardee AB. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992;257:967-71.
27. Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK. Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV(1). Biochim Biophys Acta 2001;1518:287-93.
28. Okamoto H. The Reg gene family and Reg proteins: With special attention to the regeneration of pancreatic beta-cells. J Hepatobiliary Pancreat Surg 1999;6:254-62.
29. Zweibaum A, Laburthe M, Grasset E, Louvard D. Use of cultured cell lines in studies of intestinal cell differentiation and function. In: Intestinal Absorption and Secretion. Handbook of Physiology, section 6. The Gastrointestinal System., Bethesda, MD: Am Physiol Soc., 1991. 223-55.
30. Cottu PH, Muzeau F, Estreicher A, Flejou JF, Iggo R, Thomas G, Hamelin R. Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines. Oncogene 1996;13:2727-30.
31. Chantret I, Rodolosse A, Barbat A, Dussaulx E, Brot-Laroche E, Zweibaum A, Rousset M. Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: Evidence for a glucose-dependent negative regulation. J Cell Sci 1994;107:213-25.
32. Augeron C, Laboisse C. Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate. Cancer Res 1984;44:3961-9.
33. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979;18:5294-9.
34. Rechreche H, Montalto G, Mallo GV, Vasseur S, Marasa L, Soubeyran P, Dagorn JC, Iovanna JL. pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis. Int J Cancer 1999;81:688-94.
35. Guillemain G, Munoz-Alonso MJ, Cassany A, Loizeau M, Faussat A-M, Burnol A-F, Leturque A. Karyopherin α2: A control step of glucose-sensitive gene expression in hepatic cells. Biochem J 2002; XX-XX.
36. Mitchell V, Habert-Ortoli E, Epelbaum J, Aubert JP, Beauvillain JC. Semiquantitative distribution of galanin-receptor (GAL-R1) mRNA-containing cells in the male rat hypothalamus. Neuroendocrinology 1997;66:160-72.
37. Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues: The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem 1990;265:7432-9.
38. Senegas-Balas FO, Figarella CG, Amouric MA, Guy-Crotte OM, Bertrand CA, Balas DC. Immunocytochemical demonstration of a pancreatic secretory protein of unknown function in human duodenum. J Histochem Cytochem 1991;39:915-9.
39. Sanchez D, Figarella C, Marchand-Pinatel S, Bruneau N, Guy-Crotte O. Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun 2001;284:729-37.
40. Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C. HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells. Am J Physiol 1996;271:G993-1002.
41. Masciotra L, Lechene de la Porte P, Frigerio JM, Dusetti NJ, Dagorn JC, Iovanna JL. Immunocytochemical localization of pancreatitis-associated protein in human small intestine. Dig Dis Sci 1995;40:519-24.
42. Lasserre C, Colnot C, Brechot C, Poirier F. HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postim-plantation mouse embryo. Am J Pathol 1999;154:1601-10.
43. Macadam RC, Sarela AI, Farmery SM, Robinson PA. Markham AF, Guillou PJ. Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. Br J Cancer 2000;83:188-95.
44. Bernard-Perrone FR, Renaud WP, Guy-Crotte OM, Bernard P, Figarella CG, Okamoto H, Balas DC, Senegas-Balas FO. Expression of REG protein during cell growth and differentiation of two human colon carcinoma cell lines. J Histochem Cytochem 1999;47:863-70.
45. Nishimune H, Vasseur S, Wiese S, Birling MC, Holtmann B. Sendtner M, Iovanna JL, Henderson CE. Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway. Nat Cell Biol 2000;2:906-14.
46. Ortiz EM, Dusetti NJ, Vasseur S, Malka D, Bodeker H, Dagorn JC, Iovanna JL. The pancreatitis-associated protein is induced by free radicals in AR4- 2J cells and confers cell resistance to apoptosis. Gastroenterology 1998;114:808-16.
47. Malka D, Vasseur S, Bodeker H, Ortiz EM, Dusetti NJ, Verrando P, Dagorn JC, Iovanna JL. Tumor necrosis factor alpha triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation. Gastroenterology 2000;119:816-28.