Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes

Brain Research

Volumn 1191, Issue , 2008, Pages 1-11

  Bindukumar, B ^a   Mahajan, S D ^a   Reynolds, J L ^a   Hu, Z ^b   Sykes, D E ^a   Aalinkeel, R ^a   Schwartz, S A ^a  

^a BUFFALO GENERAL HOSPITAL   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

AIDS; Astrocyte; Cannabinoid; Genomic; HIV; Mass spectrometry; Microarray; Proteomic

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; COMPLEMENTARY DNA; DRONABINOL; GENE PRODUCT; GLUTATHIONE PEROXIDASE;

ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DNA MICROARRAY; DRUG EFFECT; ENZYME ACTIVITY; GEL ELECTROPHORESIS; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; RNA TRANSLATION;

ASTROCYTES; CELLS, CULTURED; CHAPERONIN 60; CREATINE KINASE, BB FORM; FRUCTOSE-BISPHOSPHATE ALDOLASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOMICS; GLUTATHIONE PEROXIDASE; HUMANS; NERVE TISSUE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPYRUVATE HYDRATASE; PROTEOMICS; PSYCHOTROPIC DRUGS; TETRAHYDROCANNABINOL;

CANNABIS SATIVA;

EID: 38348999004     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.10.062     Document Type: Article

References (59)

1. Abrams D.I., Hilton J.F., Leiser R.J., Shade S.B., Elbeik T.A., Aweeka F.T., Benowitz N.L., Bredt B.M., Kosel B., Aberg J.A., Deeks S.G., Mitchell T.F., Mulligan K., Bacchetti P., McCune J.M., and Schambelan M. Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial. Ann. Intern. Med. 139 (2003) 258-266
2. Aebersold R., Rist B., and Gygi S.P. Quantitative proteome analysis: methods and applications. Ann. N.Y. Acad. Sci. 919 (2000) 33-47
3. Ames III A. CNS energy metabolism as related to function. Brain Res. Brain Res. Rev. 34 (2000) 42-68
4. Andon N.L., Hollingworth S., Koller A., Greenland A.J., Yates III J.R., and Haynes J.R. Proteomic characterization of wheat amyloplasts using identification of proteins by tandem mass spectrometry. Proteomics 2 (2002) 1156-1168
5. Baldi P., and Long A.D. A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics 17 (2001) 509-519
6. Beyer P.L., Palarino M.Y., Michalek D., Busenbark K., and Koller W.C. Weight change and body composition in patients with Parkinson's disease. J. Am. Diet. Assoc. 95 (1995) 979-983
7. Bindukumar B., Schwartz S.A., Nair M.P., Aalinkeel R., Kawinski E., and Chadha K.C. Prostate-specific antigen modulates the expression of genes involved in prostate tumor growth. Neoplasia 7 (2005) 241-252
8. Breci L., Hattrup E., Keeler M., Letarte J., Johnson R., and Haynes P.A. Comprehensive proteomics in yeast using chromatographic fractionation, gas phase fractionation, protein gel electrophoresis, and isoelectric focusing. Proteomics 5 (2005) 2018-2028
9. Brenneisen R., Egli A., Elsohly M.A., Henn V., and Spiess Y. The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. Int. J. Clin. Pharmacol. Ther. 34 (1996) 446-452
10. Brooke S.M., McLaughlin J.R., Cortopassi K.M., and Sapolsky R.M. Effect of GP120 on glutathione peroxidase activity in cortical cultures and the interaction with steroid hormones. J. Neurochem. 81 (2002) 277-284
11. Cabral G.A., and Mishkin E.M. Delta-9-tetrahydrocannabinol inhibits macrophage protein expression in response to bacterial immunomodulators. J. Toxicol. Environ. Health 26 (1989) 175-182
12. Cabral G.A., and Vasquez R. Delta 9-tetrahydrocannabinol suppresses macrophage extrinsic antiherpesvirus activity. Proc. Soc. Exp. Biol. Med. 199 (1992) 255-263
13. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
14. Cooper B., Eckert D., Andon N.L., Yates J.R., and Haynes P.A. Investigative proteomics: identification of an unknown plant virus from infected plants using mass spectrometry. J. Am. Soc. Mass Spectrom. 14 (2003) 736-741
15. Cunha J.M., Carlini E.A., Pereira A.E., Ramos O.L., Pimentel C., Gagliardi R., Sanvito W.L., Lander N., and Mechoulam R. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 21 (1980) 175-185
16. Eisenstein L.K., MacFarland A.S., Peng X., Hilburger M.E., Rahim R.T., Meissler Jr. L.J., Rogers T.J., Wan A.C., and Adler M.W. Effect of opioids on oral Salmonella infection and immune function. Adv. Exp. Med. Biol. 493 (2001) 169-176
17. Fischer-Stenger K., Updegrove A.W., and Cabral G.A. Delta 9-tetrahydrocannabinol decreases cytotoxic T lymphocyte activity to herpes simplex virus type 1-infected cells. Proc. Soc. Exp. Biol. Med. 200 (1992) 422-430
18. Galve-Roperh I., Sanchez C., Cortes M.L., del Pulgar T.G., Izquierdo M., and Guzman M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat. Med. 6 (2000) 313-319
19. Gerard N.P., and Gerard C. Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene. Ann. N.Y. Acad. Sci. 632 (1991) 389-390
20. Grundman M., Corey-Bloom J., Jernigan T., Archibald S., and Thal L.J. Low body weight in Alzheimer's disease is associated with mesial temporal cortex atrophy. Neurology 46 (1996) 1585-1591
21. Hampson A.J., Grimaldi M., Axelrod J., and Wink D. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 8268-8273
22. Harry J.L., Wilkins M.R., Herbert B.R., Packer N.H., Gooley A.A., and Williams K.L. Proteomics: capacity versus utility. Electrophoresis 21 (2000) 1071-1081
23. Haynes P.A., Gygi S.P., Figeys D., and Aebersold R. Proteome analysis: biological assay or data archive?. Electrophoresis 19 (1998) 1862-1871
24. Hemmer W., and Wallimann T. Functional aspects of creatine kinase in brain. Dev. Neurosci. 15 (1993) 249-260
25. Klein T.W., Kawakami Y., Newton C., and Friedman H. Marijuana components suppress induction and cytolytic function of murine cytotoxic T cells in vitro and in vivo. J. Toxicol. Environ. Health 32 (1991) 465-477
26. Klein T.W., Friedman H., and Specter S. Marijuana, immunity and infection. J. Neuroimmunol. 83 (1998) 102-115
27. Klivenyi P., Ferrante R.J., Matthews R.T., Bogdanov M.B., Klein A.M., Andreassen O.A., Mueller G., Wermer M., Kaddurah-Daouk R., and Beal M.F. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat. Med. 5 (1999) 347-350
28. Langer T., Pfeifer G., Martin J., Baumeister W., and Hartl F.U. Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity. EMBO J. 11 (1992) 4757-4765
29. Li Y., Wang X., Tian S., Guo C.J., Douglas S.D., and Ho W.Z. Methadone enhances human immunodeficiency virus infection of human immune cells. J. Infect. Dis. 185 (2002) 118-122
30. Lieuallen K., Pennacchio L.A., Park M., Myers R.M., and Lennon G.G. Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes. Hum. Mol. Genet. 10 (2001) 1867-1871
31. Lindquist S., and Craig E.A. The heat-shock proteins. Annu. Rev. Genet. 22 (1988) 631-677
32. Mahajan S.D., Schwartz S.A., Shanahan T.C., Chawda R.P., and Nair M.P. Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor. J. Immunol. 169 (2002) 3589-3599
33. Mahajan S.D., Schwartz S.A., Aalinkeel R., Chawda R.P., Sykes D.E., and Nair M.P. Morphine modulates chemokine gene regulation in normal human astrocytes. Clin. Immunol. 115 (2005) 323-332
34. Mahajan S.D., Hu Z., Reynolds J.L., Aalinkeel R., Schwartz S.A., and Nair M.P. Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesis. Mol. Diagn. Ther. 10 (2006) 257-269
35. Mailhos C., Howard M.K., and Latchman D.S. Heat shock protects neuronal cells from programmed cell death by apoptosis. Neuroscience 55 (1993) 621-627
36. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., and Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 (1990) 561-564
37. McCarty M.F. Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. Med. Hypotheses 67 (2006) 251-269
38. Morahan P.S., Klykken P.C., Smith S.H., Harris L.S., and Munson A.E. Effects of cannabinoids on host resistance to Listeria monocytogenes and herpes simplex virus. Infect. Immun. 23 (1979) 670-674
39. O'Gorman E., Beutner G., Wallimann T., and Brdiczka D. Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. Biochim. Biophys. Acta 1276 (1996) 161-170
40. Ogunro P.S., Ogungbamigbe T.O., Elemie P.O., Egbewale B.E., and Adewole T.A. Plasma selenium concentration and glutathione peroxidase activity in HIV-1/AIDS infected patients: a correlation with the disease progression. Niger. Postgrad. Med. J. 13 (2006) 1-5
41. Pandey A., and Mann M. Proteomics to study genes and genomes. Nature 405 (2000) 837-846
42. Peterson P.K., Sharp B.M., Gekker G., Portoghese P.S., Sannerud K., and Balfour Jr. H.H. Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures. Aids 4 (1990) 869-873
43. Peterson P.K., Gekker G., Hu S., Cabral G., and Lokensgard J.R. Cannabinoids and morphine differentially affect HIV-1 expression in CD4(+) lymphocyte and microglial cell cultures. J. Neuroimmunol. 147 (2004) 123-126
44. Price T.O., Ercal N., Nakaoke R., and Banks W.A. HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. Brain Res. 1045 (2005) 57-63
45. Pryce G., Ahmed Z., Hankey D.J., Jackson S.J., Croxford J.L., Pocock J.M., Ledent C., Petzold A., Thompson A.J., Giovannoni G., Cuzner M.L., and Baker D. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 126 (2003) 2191-2202
46. Semenza G.L., Jiang B.H., Leung S.W., Passantino R., Concordet J.P., Maire P., and Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271 (1996) 32529-32537
47. Shannon P., Pennacchio L.A., Houseweart M.K., Minassian B.A., and Myers R.M. Neuropathological changes in a mouse model of progressive myoclonus epilepsy: cystatin B deficiency and Unverricht-Lundborg disease. J. Neuropathol. Exp. Neurol. 61 (2002) 1085-1091
48. Shen M., and Thayer S.A. Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity. Mol. Pharmacol. 54 (1998) 459-462
49. Smith A.J., Blumenfeld H., Behar K.L., Rothman D.L., Shulman R.G., and Hyder F. Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 10765-10770
50. Speth C., Prohaszka Z., Mair M., Stockl G., Zhu X., Jobstl B., Fust G., and Dierich M.P. A 60 kD heat-shock protein-like molecule interacts with the HIV transmembrane glycoprotein gp41. Mol. Immunol. 36 (1999) 619-628
51. Tonella L., Walsh B.J., Sanchez J.C., Ou K., Wilkins M.R., Tyler M., Frutiger S., Gooley A.A., Pescaru I., Appel R.D., Yan J.X., Bairoch A., Hoogland C., Morch F.S., Hughes G.J., Williams K.L., and Hochstrasser D.F. '98 Escherichia coli SWISS-2DPAGE database update. Electrophoresis 19 (1998) 1960-1971
52. Tonge R., Shaw J., Middleton B., Rowlinson R., Rayner S., Young J., Pognan F., Hawkins E., Currie I., and Davison M. Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology. Proteomics 1 (2001) 377-396
53. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 5116-5121
54. Unlu M., Morgan M.E., and Minden J.S. Difference gel electrophoresis: a single gel method for detecting changes in protein extracts. Electrophoresis 18 (1997) 2071-2077
55. van der Stelt M., and Di Marzo V. Cannabinoid receptors and their role in neuroprotection. Neuromolecular Med. 7 (2005) 37-50
56. van der Stelt M., Veldhuis W.B., Bar P.R., Veldink G.A., Vliegenthart J.F., and Nicolay K. Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. J. Neurosci. 21 (2001) 6475-6479
57. Wessel D., and Flugge U.I. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138 (1984) 141-143
58. Wilm M., Shevchenko A., Houthaeve T., Breit S., Schweigerer L., Fotsis T., and Mann M. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 379 (1996) 466-469
59. Zhou G., Li H., DeCamp D., Chen S., Shu H., Gong Y., Flaig M., Gillespie J.W., Hu N., Taylor P.R., Emmert-Buck M.R., Liotta L.A., Petricoin III E.F., and Zhao Y. 2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers. Mol. Cell Proteomics. 1 (2002) 117-124