Novel heterocycle-substituted pyrimidines as inhibitors of NF-κB transcription regulation related to TNF-α cytokine release

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 653-656

  Ha, Hyung Ho ^a   Kim, Jee Seon ^a   Kim, B Moon ^a  

^a Seoul National University   (South Korea)

Author keywords

Anti inflammation; Glycogen synthase kinase 3 ; Heterocyclic fused ring; Nuclear factor B; TNF cytokine

Indexed keywords

DORAMAPIMOD; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG INDICATION; DRUG STRUCTURE; ENZYME INHIBITION; INFLAMMATION; MOUSE; NONHUMAN; REPORTER GENE; TRANSCRIPTION REGULATION;

ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; HETEROCYCLIC COMPOUNDS; HUMANS; NF-KAPPA B; PYRIMIDINES; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38149050566     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.064     Document Type: Article

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