5-Aryl-pyrazolo[3,4-b]pyridines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 9, 2003, Pages 1577-1580

  Witherington, Jason ^a   Bordas, Vincent ^a   Garland, Stephen L ^a   Hickey, Deirdre M B ^a   Ife, Robert J ^a   Liddle, John ^a   Saunders, Martin ^a   Smith, David G ^a   Ward, Robert W ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; GLYCOGEN SYNTHASE KINASE 3; LITHIUM; NITROGEN; PROTEIN INHIBITOR; PYRIDAZINE; PYRIDINE DERIVATIVE; 2 AMINOTHIAZOLE DERIVATIVE; AMIDE; CYCLIN DEPENDENT KINASE 2; PYRIMIDINE; THIAZOLE DERIVATIVE; WATER;

ALZHEIMER DISEASE; ARTICLE; BIPOLAR DISORDER; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; LIQUID CHROMATOGRAPHY; MAMMAL CELL; MASS SPECTROMETRY; MICROTUBULE; NERVE DEGENERATION; NEUROPROTECTION; PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; BINDING SITE; CHEMICAL BOND; CRYSTALLIZATION; DRUG STRUCTURE; HYDROGEN BOND; MOLECULE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 0037420819     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00134-3     Document Type: Article

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