Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 4, 2006, Pages 944-954

  Allen, Scott H ^a   Johns, Brian A ^a   Gudmundsson, Kristjan S ^a   Freeman, George A ^a   Boyd Jr , F Leslie ^a   Sexton, Connie H ^a   Selleseth, Dean W ^a   Creech, Katrina L ^a   Moniri, Kelly R ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Alkynyl ketone; HSV; Pyrazolo 1,5 a pyridines; Pyrimidine synthesis

Indexed keywords

1 [2 (4 FLUOROPHENYL) 6 (TRIFLUOROMETHYL)PYRAZOLO[1,5 A]PYRIDIN 3 YL]2 PROPYN 1 OL; 1 [2 (4 FLUOROPHENYL) 6 (TRIFLUOROMETHYL)PYRAZOLO[1,5 A]PYRIDIN 3 YL]2 PROPYN 1 ONE; 2 (4 FLUOROPHENYL) 6 (TRIFLUOROMETHYL)PYRAZOLO[1,5 A]PYRIDINE 3 CARBALDEHYDE; 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) N ISOPROPYLPYRAZOLO[1,5 A]PYRIDIN 6 AMINE; 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL)PYRAZOLO[1,5 A]PYRIDIN 6 AMINE DIHYDROCHLORIDE; 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL)PYRAZOLO[1,5 A]PYRIDIN 6 YL]METHANOL; 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL)PYRAZOLO[1,5 A]PYRIDINE 6 CARBOXYLIC ACID HYDROCHLORIDE; 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] N CYCLOPROPYL 2 (4 FLUOROPHENYL) 7 METHYLPYRAZOLO[1,5 A]PYRIDINE 6 CARBOXAMIDE; 4 [7 CHLORO 2 (4 FLUOROPHENYL) 6 (TRIETHOXYMETHYL)PYRAZOLO[1,5 A]PYRIDIN 3 YL] N CYCLOPENTYL 2 PYRIMIDINAMINE; 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) N [2 (4 MORPHOLINYL)ETHYL]PYRAZO[1,5 A]PYRIDINE 6 CARBOXAMIDE; 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) N [2 HYDROXY 1 (HYDROXYMETHYL)ETHYL]PYRAZOLO[1,5 A]PYRIDINE 6 CARBOXAMIDE; 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) N [3 (1H IMIDAZOL 1 YL)PROPYL]PYRAZOLO[1,5 A]PYRIDINE 6 CARBOXAMIDE; 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) N HYDROXYPRAZOLO[1,5 A]PYRIDINE 6 CARBOXAMIDE; 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) N,N DIMETHYLPYRAZOLO[1,5 A]PYRIDINE 6 CARBOXYAMIDE; 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL)PYRAZOLO[1,5 A]PYRIDINE 6 CARBOXYLIC ACID; 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL)PYRAZOLO[1,5 A]PYRIDINE 6 YL]METHANOL; ACICLOVIR; ETHYL 7 (CYCLOPENTYLAMINO) 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) [1,5 A]PYRIDINE 6 CARBOXYLATE; GW 3733; N CYCLOPENTYL 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL) 6 (1 PYRROLIDINYLCARBONYL)PYRAZOLO[1,5 A]PYRIDIN 7 AMINE; N CYCLOPENTYL 3 [2 (CYCLOPENTYLAMINO) 4 PYRIMIDINYL] 2 (4 FLUOROPHENYL)PYRAZOLO[1,5 A]PYRIDIN 6 AMINE; N CYCLOPENTYL 4 [2 (4 FLUOROPHENYL) 6 (TRIFLUOROMETHYL)PYRAZOLO[1,5 A]PYRIDIN 3 YL] 2 PYRIMIDINAMINE; N CYCLOPENTYL 4 [2 (4 FLUOROPHENYL) 6 METHYL PYRAZOLO[1,5 A]PYRIDIN 3 YL] 2 PYRIMIDINAMINE; PYRAZOLO[1,5 A]PYRIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION LINE; VERO CELL;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; HERPESVIRIDAE; MOLECULAR STRUCTURE; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

SIMPLEXVIRUS;

EID: 30344476416     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.015     Document Type: Article

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