IL-15 regulates immature B-cell homing in an Ly49D-, IL-12-, and IL-18-dependent manner

Blood

Volumn 111, Issue 1, 2008, Pages 50-59

  Hart, Gili ^a   Avin Wittenberg, Tamar ^a   Shachar, Idit ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 15; INTERLEUKIN 18; LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN LY49D; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENETIC TRANSCRIPTION; HUMORAL IMMUNITY; IMMUNE RESPONSE; INFLAMMATION; LYMPH NODE; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPLEEN; TRANSCRIPTION REGULATION;

EID: 38049105642     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-07-099598     Document Type: Article

References (40)

1. Butcher EC. Leukocyte-endothelial cell recognition: 3 (or more) steps to specificity and diversity. Cell. 1991;67:1033-1036.
2. Shimizu Y, Newman W, Tanaka Y, Shaw S. Lymphocyte interactions with endothelial cells. Immunol Today. 1992;13:106-112.
3. Mackay CR, Imhof BA. Cell adhesion in the immune system. Immunol Today. 1993;14:99-102.
4. Schall TJ, Bacon KB. Chemokines, leukocyte trafficking, and inflammation. Curr Opin Immunol. 1994;6:865-873.
5. Hogg N, Berlin C. Structure and function of adhesion receptors in leukocyte trafficking. Immunol Today. 1995;16:327-330.
6. Imhof BA, Dunon D. Leukocyte migration and adhesion. Adv Immunol. 1995;58:345-416.
7. Butcher EC, Picker IJ. Lymphocyte homing and homeostasis. Science. 1996;272:60-66.
8. Springer T. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol. 1995;57:827-872.
9. Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation, II: heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol. 1993;151:4431-4444.
10. Rolink AG, Andersson J, Melchers F. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur J Immunol. 1998;28:3738-3748.
11. Picker LJ, Butcher EC. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol. 1992;10:561-591.
12. Flaishon L, Hershkovitz R, Lantner F, et al. Autocrine secretion of interferon γ negatively regulates homing of immature B cells. J Exp Med. 2000;192:1381-1387.
13. Flaishon L, Becker-Herman S, Hart G, Levo Y, Kuziel WA, Shachar I. Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration. Blood. 2004;104:933-941.
14. Flaishon L, Lantner F, Hershkovitz R, Levo Y, Shachar I. Low levels of IFN-γ down-regulate the integrin-dependent adhesion of B cells by inhibition of cytoskeleton rearrangement. J Biol Chem. 2001;276:46701-46706.
15. Flaishon L, Topilski I, Shoseyov D, et al. Anti-inflammatory properties of low levels of IFN-γ. J Immunol. 2002;168:3707-3711.
16. Hart G, Flaishon L, Becker-Herman S, Shachar I. The Ly49D receptor expressed on immature B cells regulates their interferon gamma secretion, actin polymerization and homing. J Immunol. 2003;171:4630-4638.
17. Hart G, Flaishon L, Becker-Herman S, Shachar I. A tight regulation of IFN-g transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2. J Immunol. 2005;175:5034-5042.
18. Brunda MJ. Interleukin-12. J Leukoc Biol. 1994;55:280-288.
19. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood. 1994;84:4008-4027.
20. Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T, Nakanishi K. Regulation of interferon-gamma production by IL-12 and IL-18. Curr Opin Immunol. 1998;10:259-264.
21. Hart G, Flaishon L, Shachar I. IL-12 and IL-18 downregulate B cell migration in an Ly49D-dependent manner. Eur J Immunol. 2007;37:1996-2007.
22. Waldmann TA. IL-15 in the life and death of lymphocytes: immunotherapeutic implications. Trends Mol Med. 2003;9:517-521.
23. Bulfone-Paus S, Bulanova E, Budagian V, Paus R. The interleukin-15/ interleukin-15 receptor system as a model for juxtacrine and reverse signaling. Bioessays. 2006;28:362-377.
24. Lodolce J, Burkett P, Koka R, et al. Interleukin-15 and the regulation of lymphoid homeostasis. Mol Immunol. 2002;39:537-544.
25. Strengell M, Matikainen S, Siren J, et al. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J Immunol. 2003;170:5464-5469.
26. Fehniger TA, Yu H, Cooper MA, Suzuki K, Shah MH, Caligiuri MA. Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. J Immunol. 2000;164:1643-1647.
27. Gollob JA, Mier JW, Veenstra K, et al. Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response. Clin Cancer Res. 2000;6:1678-1692.
28. Elliott EA, Drake JR, Amigorena S, et al. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med. 1994;179:681-694.
29. Shachar I, Elliot EA, Chasnoff B, Grewal IS, Flavell RA. Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforsm. Immunity. 1995;3:373-383.
30. Becker-Herman S, Lantner F, Shachar I. Id2 negatively regulates B cell differentiation in the spleen. J Immunol. 2002;168:5507-5513.
31. Su TT, Rawlings DJ. Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J Immunol. 2002;168:2101-2110.
32. Luger D, Dayan M, Zinger H, Liu JP, Mozes E. A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation. J Clin Immunol. 2004;24:579-590.
33. Shachar I, Flavell RA. Requirement for invariant chain in B cell maturation and function. Science. 1996;274:106-108.
34. Rubinstein MP, Kovar M, Purton JF, et al. Converting IL-15 to a superagonist by binding to soluble IL-15Rα. Proc Natl Acad Sci U S A. 2006;103:9166-9171.
35. Saito S, Kuwashima N, Koizumi H, et al. In vivo function of homing receptors participating in lymphocyte recirculation: transfer analysis in SCID mice. Pathobiology. 1995;63:305-313.
36. Kraal G, Schornagel K, Streeter PR, Holzmann B, Butcher EC. Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. Am J Pathol. 1995;147:763-771.
37. Nolte MA, Hamann A, Kraal G, Mebius RE. The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors. Immunology. 2002;106:299-307.
38. Lo CG, Lu TT, Cyster JG. Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med. 2003;197:353-361.
39. Budagian V, Bulanova E, Paus R, Bulfone-Paus S. IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev. 2006;17:259-280.
40. Nakahira M, Ahn HJ, Park WR, et al. Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by upregulating the binding activity of IL-18-induced activator protein 1. J Immunol. 2002;168:1146-1153.