Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-γ production in vivo

Journal of Immunology

Volumn 164, Issue 4, 2000, Pages 1643-1647

  Fehniger, Todd A ^a,b   Yu, Haixin ^a   Cooper, Megan A ^a   Suzuki, Kazuhiro ^a   Shah, Manisha H ^a   Caligiuri, Michael A ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; INTERFERON PRODUCTION; MACROPHAGE; MORTALITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SENSITIZATION; SHOCK; SHWARTZMAN PHENOMENON; SPLEEN CELL;

EID: 0034651845     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.4.1643     Document Type: Article

References (30)

1. Waldmann, T. A., and Y. Tagaya. 1999. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 17:19.
2. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, et al. 1994. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264:965.
3. Bamford, R. N., A. J. Grant, J. D. Burton, C. Peters, G. Kurys, C. K. Goldman, J. Brennan, E. Roessler, and T. A. Waldmann. 1994. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91:4940.
4. Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, and D. Anderson. 1994. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822.
5. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395.
6. Giri, J. G., S. Kumaki, M. Ahdieh, D. J. Friend, A. Loomis, K. Shanebeck, R. DuBose, D. Cosman, L. S. Park, and D. M. Anderson. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J. 14:3654.
7. Carson, W. E., M. E. Ross, R. A. Baiocchi, M. J. Marien, N. Boiani, K. Grabstein, and M. A. Caligiuri. 1995. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro. J. Clin. Invest. 96:2578.
8. Doherty, T. M., R. A. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735.
9. Billiau, A. 1988. Gamma-interferon: the match that lights the fire? Immunol. Today 9:37.
10. Brozna, J. P. 1990. Shwartzman reaction. Semin. Thromb. Hemost. 16:326.
11. Ozmen, L., M. Pericin, J. Hakimi, R. A. Chizzonite, M. Wysocka, G. Trinchieri, M. Gately, and G. Garotta. 1994. Interleukin 12, interferon γ, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med. 180:907.
12. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
13. Movat, H. Z., C. E. Burrowes, M. I. Cybulsky, and C. A. Dinarello. 1987. Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor: synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am. J. Pathol. 129:463.
14. Biron, C. A. 1997. Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9:24.
15. Trinchieri, G. 1997. Cytokines acting on or secreted by macrophages during intracellular infection (IL-15, IL-12, IFN-γ). Curr. Opin. Immunol. 9:17.
16. Bluman, E. M., K. J. Bartynski, B. R. Avalos, and M. A. Caligiuri. 1996. Human natural killer cells produce abundant macrophage inflammatory protein-1α in response to monocyte-derived cytokines. J. Clin. Invest. 97:2722.
17. Heremans, H., C. Dillen, J. van Damme, and A. Billiau. 1994. Essential role for natural killer cells in the lethal lipopolysaccharide-induced Shwartzman-like reaction in mice. Eur. J. Immunol. 24:1155.
18. Nguyen, K. B., and C. A. Biron. 1999. Synergism for cytokine-mediated disease during concurrent endotoxin and viral challenges: roles for NK and T cell IFN-γ production. J. Immunol. 162:5238.
19. Tanaka, T., M. Tsudo, H. Karasuyama, F. Kitamura, T. Kono, M. Hatakeyama, T. Taniguchi, and M. Miyasaka. 1991. A novel monoclonal antibody against murine IL-2 receptor β-chain: characterization of receptor expression in normal lymphoid cells and EL-4 cells. J. Immunol. 147:2222.
20. Fehniger, T. A., M. S. Shah, M. J. Turner, J. VanDeusen, K. Suzuki, M. A. Cooper, M. Wechser, F. Goodsaid, and M. A. Caligiuri. 1999. Differential cytokine and chemokine gene expression by human natural killer cells activated by IL-15 or IL-18 in combination with IL-12: implications for the innate immune response. J. Immunol. 162:4511.
21. Gibson, U. E., C. A. Heid, and P. M. Williams. 1996. A novel method for real time quantitative RT-PCR. Genome Res. 6:995.
22. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
23. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
24. + T cell-mediated immunity against Toxoplasma gondii infection in mice. J. Immunol. 157:2103.
25. Ruchatz, H., B. P. Leung, X. Q. Wei, I. B. McInnes, and F. Y. Liew. 1998. Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J. Immunol. 160:5654.
26. Kim, Y. S., W. Maslinski, X. X. Zheng, A. C. Stevens, X. C. Li, G. H. Tesch, V. R. Kelley, and T. B. Strom. 1998. Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fcγ2a protein blocks delayed-type hypersensitivity. J. Immunol. 160:5742.
27. Mody, C. H., J. C. Spurrell, and C. J. Wood. 1998. Interleukin-15 induces anti-microbial activity after release by Cryptococcus neoformans-stimulated monocytes. J. Infect. Dis. 178:803.
28. James, S. L., and C. Nacy. 1993. Effector functions of activated macrophages against parasites. Curr. Opin. Immunol. 5:518.
29. - cells. J. Immunol. 160:4738.
30. Hunter, C. A., L. Ellis-Neyer, K. E. Gabriel, M. K. Kennedy, K. H. Grabstein, P. S. Linsley, and J. S. Remington. 1997. The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii. J. Immunol. 158:2285.