A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins

Regulatory Toxicology and Pharmacology

Volumn 39, Issue 2, 2004, Pages 87-98

  Thomas, K ^a   Aalbers, M ^b   Bannon, G A ^c   Bartels, M ^d   Dearman, R J ^e   Esdaile, D J ^f   Fu, T J ^g   Glatt, C M ^h   Hadfield, N ^e   Hatzos, C ^g   Hefle, S L ⁱ   Heylings, J R ^e   Goodman, R E ^c   Henry, B ^j   Herouet, C ^f   Holsapple, M ^a   Ladics, G S ^h   Landry, T D ^d   MacIntosh, S C ^j   Rice, E A ^c   Privalle, L S ^k,m   Steiner, H Y ^k   Teshima, R ^l   Van Ree, R ^b   Woolhiser, M ^d   Zawodny, J ^k   more..

^a ILSI HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE   (United States)

^b SANQUIN RESEARCH   (Netherlands)

^c MONSANTO COMPANY   (United States)

^d DOW CHEMICAL COMPANY   (United States)

^e JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^f BAYER AG   (Germany)

^g Natl Ctr Food Safety and Technol   (United States)

^h DUPONT COMPANY   (United States)

ⁱ UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^j BAYER CROPSCIENCE   (United States)

^k SYNGENTA BIOTECHNOLOGY INC   (United States)

^l NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^m BASF CORPORATION   (United States)

more..

Author keywords

Biotechnology; Digestive stability; Genetically modified foods; Pepsinolysis; Protein allergenicity

Indexed keywords

ACYLTRANSFERASE; BETA LACTOGLOBULIN; BOVINE SERUM ALBUMIN; CONCANAVALIN A; HORSERADISH PEROXIDASE; OVALBUMIN; OVOMUCOID; PEPSIN A; PHOSPHINOTHRICIN; RIBULOSEBISPHOSPHATE CARBOXYLASE; SOYBEAN TRYPSIN INHIBITOR;

ACIDITY; ARTICLE; BIOSAFETY; CLINICAL PROTOCOL; ENZYME ACTIVITY; ENZYME ASSAY; GEL; LABORATORY TEST; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPRODUCIBILITY; RISK ASSESSMENT; SAMPLING; STAINING;

DIGESTION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GASTROINTESTINAL AGENTS; HYDROGEN-ION CONCENTRATION; LABORATORY TECHNIQUES AND PROCEDURES; PEPSIN A; PEPTIDE FRAGMENTS; PROTEINS; REPRODUCIBILITY OF RESULTS;

ARA; ARACHIS HYPOGAEA; ARMORACIA RUSTICANA; BOVINAE; GLYCINE MAX;

EID: 12144289196     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yrtph.2003.11.003     Document Type: Article

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