Alterations in T cell signal transduction by M. leprae antigens is associated with downregulation of second messengers PKC, calcium, calcineurin, MAPK and various transcription factors in leprosy patients

Molecular Immunology

Volumn 44, Issue 8, 2007, Pages 2066-2077

  Chattree, Vineeta ^a   Khanna, Neena ^a   Rao, D N ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Anergy; IL 2; Immunomodulators; Leprosy; M. leprae antigen; Signal transduction; T cell; Transcription factors

Indexed keywords

BACTERIAL ANTIGEN; CALCINEURIN; CALCIUM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; INTERLEUKIN 2; LIPOSOME; MITOGEN ACTIVATED PROTEIN KINASE; MURABUTIDE; PROTEIN FOS; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; MESSENGER RNA;

ANTIGEN STRUCTURE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CLONAL ANERGY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LEPROSY; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION; T LYMPHOCYTE; CALCIUM SIGNALING; CELL CULTURE; CLINICAL TRIAL; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE;

MYCOBACTERIUM LEPRAE;

ANTIGENS, BACTERIAL; CALCINEURIN; CALCIUM; CALCIUM SIGNALING; CELL PROLIFERATION; CELLS, CULTURED; CLONAL ANERGY; DOWN-REGULATION; FEMALE; HUMANS; LEPROSY; LYMPHOCYTE ACTIVATION; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MYCOBACTERIUM LEPRAE; PROTEIN KINASE C; RNA, MESSENGER; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 37849189882     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.09.008     Document Type: Article

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