Expression of costimulatory molecules (CD80, CD86, CD28, CD152), accessory molecules (TCR αβ, TCR γδ) and T cell lineage molecules (CD4+, CD8+) in PBMC of leprosy patients using Mycobacterium leprae antigen (MLCWA) with murabutide and T cell peptide of Trat protein

International Immunopharmacology

Volumn 4, Issue 1, 2004, Pages 1-14

  Sridevi, K ^a   Neena, Khanna ^a   Chitralekha, K T ^a   Arif, A K ^a   Tomar, D ^a   Rao, D N ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Costimulatory molecules; Immunomodulators; Leprosy; M. leprae antigen

Indexed keywords

B7 ANTIGEN; BACTERIAL ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 2; LIPOSOME; LYMPHOCYTE ANTIGEN; M PROTEIN; MURABUTIDE; MYCOBACTERIUM LEPRAE TOTAL CELL WALL ANTIGEN; PROTEIN TRAT; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHABETA; T LYMPHOCYTE RECEPTOR GAMMADELTA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BACTERIAL CELL WALL; CELL DIFFERENTIATION; CELL FUNCTION; CLONAL ANERGY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEPROMATOUS LEPROSY; LYMPHOCYTE PROLIFERATION; MOLECULAR DYNAMICS; MOLECULE; MYCOBACTERIUM LEPRAE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUBERCULOID LEPROSY;

EID: 1242306588     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2003.09.001     Document Type: Article

References (34)

1. Cantrell D. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:1996;259-274.
2. Linsley P.S., Brady W., Grosmaire L., Aruffo A., Damle N.K., Ledbetter J.A. Binding of the B cell activation B7 to CD28 costimulates T cell proliferation and interleukin-2 mRNA accumulation. J. Exp. Med. 173:1991;721-730.
3. Eager T.N., Karandikar N.J., Bluestone J.A., Miller S.D. The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. Eur. J. Immunol. 32:2002;972-981.
4. Reiser H., Stadecker M.J. Mechanism of disease: costimulatory B7 molecule in the pathogenesis of infections and autoimmune disease. N. Engl. J. Med. 335:1996;1369-1377.
5. Zea A.H., Ochoa M.T., Ghosh P., Longo D.L., Alvord W.G., Valderrama L.et al. Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. Infect. Immun. 66:1998;499-504.
6. + T cell activation and CTL effector function. J. Immunol. 168:2002;3786-3792.
7. Agrewala J.N., Kumar B., Vohra H. Potential role of B7.2 and CD28 molecule in immunosuppression in leprosy. Clin. Exp. Immunol. 111:1998;56-63.
8. Morris M.F., Vargas C.M.G., Fierros S.N., Bustamante F.A., Petrovna G.Z., Navarro A.D.et al. Addition of anti CD28 antibodies restores PBMC proliferation and IFN-γ production in lepromatous leprosy patients. J. Interferon Cytokine Res. 19:1999;1237-1243.
9. Schlienger K., Uyemura K., Jullien D., Sieling P.A., Rea T.H., Linsley P.S.et al. B7.1, but not CD28 is crucial for the maintenance of the CD4+ T cell response in the human leprosy. J. Immunol. 61:1998;2407-2413.
10. Hattori H., Okano M., Yoshino T., Akagi T., Nakayama E., Saito C.et al. Expression of costimulatory CD80/CD86-CD28/CD152 molecules in nasal mucosa of patients with perennial allergic rhinitis. Clin. Exp. Allergy. 31:2001;1242-1249.
11. Goasduff T., Darcissac E.C., Vidal V., Capron A., Bahr G.M. The transcriptional response of human macrophages to murabutide reflects a spectrum of biological effects for the synthetic immunomodulators. Clin. Exp. Immunol. 128:2002;474-482.
12. Ridley D.S., Jopling W.H. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. 34:1966;255-273.
13. Sridevi K., Khanna N., Chattree V., Pal C., Haq W., Rao D.N. Reversal of T cell anergy in leprosy patients: in vitro presentation with Mycobacterium leprae antigens using murabutide and TraT peptide in liposomal delivery. Int. Immunopharmacol. 3/12:2003;1589-1600.
14. Turanek J., Toman M., Novak J., Krchnak V., Horavova P. Adjuvant effect of liposomes and adamantylamide dipeptide on antigenicity of entrapped synthetic peptide derived from HIV-1 transmembrane region glycoprotein gp41. Immunol. Lett. 39:1994;157-161.
15. Shi Y., Rock L.K. Cell death releases endogenous adjuvants that selectively enhance surveillance of particulate antigen. Eur. J. Immunol. 32:2002;155-162.
16. De Becker G., Moulin V., Tielemans F., De Mattia F., Leo O.et al. Regulation of T helper cell differentiation in vivo by soluble and membrane proteins provided by antigen-presenting cells. Eur. J. Immunol. 28:1998;3161-3171.
17. Li J., Yang Y., Inoue H., Mori M., Akiyoshi T. The expression of costimulatory molecules CD80 and CD86 in human carcinoma cell lines: its regulation by interferon γ and interleukin-10. Cancer Immunol. Immunother. 43:1996;213-219.
18. LaBelle J.L., Hanke C.A., Blazar B.R., Truitt R.L. Negative effect of CTLA-4 on induction of T cell immunity in vivo to B7-1+, but not B7-2+, murine myeloogenous leukemia. Blood. 99:2002;2146-2153.
19. Zaru R., Berrie C.P., Iurisci C., Corda D., Valitutti S. CD28 co-stimulates TCR/CD3-induced phosphoinositide turnover in human T lymphocytes. Eur. J. Immunol. 3:2001;2438-2447.
20. Dubey C., Croft M., Swain S.L. Costimulatory requirements of naïve CD4+ T cells. J. Immunol. 155:1995;45-57.
21. Lanier L.L., O'Fallon S., Somoza C., Phillips J.H., Linsley P.S., Okumura K.et al. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154:1995;97-105.
22. Sporici R.A., Perrin P.J. Costimulation of memory T-cells by ICOS: a potential therapeutic target for autoimmunity? Clin. Immunol. 100:2001;263-269.
23. Sachdeva G., Kaur G., Bhutani L.K., Bamezai R. Genetic variations at the T cell receptor γ locus in circulating peripheral blood mononuclear cells of clinically categorized leprosy patients. Hum. Genet. 100:1997;30-34.
24. Lanier L.L., Serafini A.T., Ruitenberg J.J., Cwirla S., Federspiel N.A., Phillips J.H.et al. The gamma T-cell antigen receptor. J. Clin. Immunol. 7:1987;429-440.
25. Gonzalez-Amaro R., Portales-Perez D.P., Baranda L., Moncada B., Toro C., Lopez-Briones S.et al. Co-stimulatory signals increase the reactivity of gammadelta T cells towards mycobacterial antigens. Clin. Exp. Immunol. 120:2000;468-475.
26. Fujita M., Miyachi Y., Nakata K., Imamura S. Appearance of gamma delta T-cell receptor-positive cells in the lepromin reaction of human skin. Immunol. Lett. 35:1993;39-44.
27. Salgame P.R., Abrams J.S., Clayburger C. Differing lymphokine profiles of functional subsets of human CD4+ and CD8 T cell clones. Science. 254:1991;279-282.
28. Kaplan G., Van Voorhis W.C., Sarno E.N., Nogueira N., Cohn Z.A. The cutaneous infiltrates of leprosy, a transmission electron microscopy study. J. Exp. Med. 158:1983;1145-1159.
29. Modlin R.L. TH1-TH2 paradigm: insights from leprosy. J. Invest. Dermatol. 102:1994;828-832.
30. Elloso M.M., Scott P. Differential requirement of CD28 for IL-12 receptor expression and function in CD4 (+) and CD8 (+) T cells. Eur. J. Immunol. 31:2001;384-395.
31. Doyle A.M., Mullen C.A., Villarino V.A., Hutchins A.S., High F.A., Lee H.W.et al. Induction of cytotoxic T lymphocyte antigen 4(CTLA-4) restricts clonal expansion of helper T cells. J. Exp. Med. 194:2001;893-902.
32. Masteller E.L., Chuang E., Mullen A.C., Reiner S.L., Thompson C.B. Structural analysis of CTLA-4 function in vivo. J. Immunol. 64:2000;5319-5327.
33. Sundstedt A., Dohlsten M. In vivo anergized CD4+ T cells have defective expression and function of the activating protein-1 transcription factor. J. Immunol. 161:1998;5930.
34. Schwartz R.H. Models of T-cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1996;1-8.