The Per2 negative feedback loop sets the period in the mammalian circadian clock mechanism

PLoS Computational Biology

Volumn 3, Issue 12, 2007, Pages 2476-2486

  Wilkins, A Katharina ^a,b   Barton, Paul I ^a   Tidor, Bruce ^a,b,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOCKS; FEEDBACK; MAMMALS; SENSITIVITY ANALYSIS;

CELL CYCLE; CIRCADIAN CLOCK; CIRCADIAN RHYTHMS; CLOCK SYSTEMS; FUNCTIONAL CHARACTERISTICS; MOLECULAR NETWORKS; NEGATIVE FEEDBACK LOOP; PERIOD OF OSCILLATION; RATE PROCESS; SEASONAL VARIATION;

NUMERICAL METHODS;

CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; PER1 PROTEIN; PER2 PROTEIN; NUCLEAR PROTEIN; PER2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CIRCADIAN RHYTHM; ENZYME ACTIVITY; MATHEMATICAL MODEL; MUTATIONAL ANALYSIS; NEGATIVE FEEDBACK; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; ANIMAL; BIOLOGICAL MODEL; BIOLOGICAL RHYTHM; COMPUTER SIMULATION; FEEDBACK SYSTEM; HUMAN; METABOLISM; METHODOLOGY; OSCILLOMETRY; PERIODICITY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MAMMALIA;

ANIMALS; BIOLOGICAL CLOCKS; COMPUTER SIMULATION; FEEDBACK; HUMANS; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; OSCILLOMETRY; PERIODICITY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 37849004604     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0030242     Document Type: Article

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