The mPer2 gene encodes a functional component of the mammalian circadian clock

Nature

Volumn 400, Issue 6740, 1999, Pages 169-173

  Zheng, Blnhal ^a   Larkin, David W ^a   Albrecht, Urs ^a,b   Sun, Zhong Sheng ^a   Sage, Marijke ^a   Eichele, Gregor ^a,b   Lee, Cheng Chi ^a   Bradley, Allan ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL RHYTHM; CIRCADIAN RHYTHM; DIMERIZATION; DROSOPHILA; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC CONSERVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS;

ANIMALS; BIOLOGICAL CLOCKS; CELL CYCLE PROTEINS; CIRCADIAN RHYTHM; DARKNESS; DROSOPHILA; FOURIER ANALYSIS; HOMOZYGOTE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE DELETION; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0033536228     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/22118     Document Type: Article

References (30)

1. Pittendrigh, C. S. Temporal organization: reflections of a Darwinian clock-watcher. Annu. Rev. Physiol. 55, 16-54 (1993).
2. Sun, Z. S. et al. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell 90, 1003-1011 (1997).
3. Tei, H. et al. Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature 389, 512-516 (1997).
4. Albrecht, U., Sun, Z. S., Eichele, G. & Lee, C. C. A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell 91, 1055-1064 (1997).
5. Shearman, L. P., Zylka, M. J., Weaver, D. R., Kolakowski, L. F. Jr & Reppert, S. M. Two period homologs; circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron 19, 1261-1269 (1997).
6. Takumi, T. et al. A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus. Genes Cells 3, 167-176 (1998).
7. Zylka, M. J., Shearman, L. P., Weaver, D. R. & Reppert, S. M. Three period homologs in mammals: differential light responses in the supracbiasmatic circadian clock and oscillating transcripts outside of brain. Neuron 20, 1103-1110 (1998).
8. Takumi, T. et al. A light-independent oscillatory gene mPer3 in mouse SCN and OVLT. EMBO J. 17, 4753-4759 (1998).
9. Huang, Z. J., Edery, I. & Rosbash, M. PAS is a dimerization domain common to Drosophila Period and several transcription factors. Nature 364, 259-262 (1993).
10. Crosthwaite, S. K., Dunlap, J. C. & Loros, J. J. Neurospora wc-1 and wc-2: transcription, photo-responses, and the origins of circadian rhythmicity. Science 276, 763-769 (1997).
11. King, D. P. et al. Positional cloning of the mouse circadian Clock gene. Cell 89, 641-653 (1997).
12. Rutila, J. E. et al. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell 93, 805-814 (1998).
13. Allada, R., White, N. E, So, W. V., Hall, J. C. & Rosbash, M. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell 93, 791-804 (1998).
14. Ponting, C. P. & Aravind, L. PAS: a multifunctional domain family comes to light. Curr. Biol. 7, R674-R677 (1997).
15. Bracewell, R. N. The Hartley Transform (Orford Univ. Press, New York, 1986).
16. Aschoff, J. in Handbook of Behavioral Neurobiology 4: Biological Rhythms (ed. Aschoff, J.) 3-10 (Plenum, New York, 1981).
17. Ibuka, N., Inouye, S. I. & Kawamura, H. Analysis of sleep-wakefulness rhythms in male rats after suprachiasmatic nucleus lesions and ocular enucleation. Brain Res. 122, 33-47 (1977).
18. Vitaterna, M. H. et al. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior, Science 264, 719-725 (1994).
19. Dowse, H. B. & Ringo, J. M. Further evidence that the circadian clock in Drosophila is a population of coupled ultradian oscillators. J. Biol. Rhythms 2, 65-76 (1987).
20. Hamblen-Coyle, M. J., Wheeler, D. A., Rutila, J. E., Rosbash, M. & Hall, J. C. Behavior of period-altered rhythm mutants of Drosophila in light:dark cycles. J. Insect Behav. 5, 417-446 (1992).
21. Ralph, M. R. & Menaker, M. A mutation of the circadian system in golden hamsters. Science 241, 1225-1227 (1988).
22. Hardin, P. E., Hall, J. C. & Rosbash, M. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343, 536-540 (1990).
23. Dunlap, J. C. Genetics and molecular analysis of circadian rhythms. Annu. Rev. Genet. 30, 579-601 (1996).
24. Balsalobre, A., Damiola, F. & Schibler, U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93, 929-937 (1998).
25. Sangoram, A. M. et al. Mammalian circadian autoregulatory loop: A Timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMALI-induced transcription. Neuron 21, 1101-1113 (1998).
26. Bae, K., Lee, C., Sidote, D., Chuang, K. Y. & Edery, I. Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM fucntion as positive regulators Mol. Cell Biol. 18, 6142-6151 (1998).
27. Matzuk, M. M., Finegold, M. J., Su, J. G., Hsueh, A. J. & Bradley, A. Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360, 313-319 (1992).
28. Ramirez-Solis, R., Davis, A. C. & Bradley, A. Gene targeting in embryonic stem cells. Methods Enzymol. 225, 855-878 (1993).
29. Sokolove, P. G. & Bushell, W. N. The chi square periodogram: its utility for analysis of circadian rhythms. J. Theor. Biol. 72, 131-160 (1978).
30. Albrecht, U., Eichele, G., Helms, J. A. & Lu, H. in Molecular ami Cellular Methods in Developmental Toxicology (ed. Daston, G. P.) 23-48 (CRC Press, Boca Raton, FL, 1997).