-
1
-
-
0034109921
-
Carcinogenesis in mouse and human cells: parallels and paradoxes
-
Balmain A., and Harris C.C. Carcinogenesis in mouse and human cells: parallels and paradoxes. Carcinogenesis 21 (2000) 371-377
-
(2000)
Carcinogenesis
, vol.21
, pp. 371-377
-
-
Balmain, A.1
Harris, C.C.2
-
2
-
-
1342288971
-
Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice
-
Rangarajan A., and Weinberg R.A. Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer 3 (2003) 952-959
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 952-959
-
-
Rangarajan, A.1
Weinberg, R.A.2
-
3
-
-
0029098336
-
Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors
-
Maronpot R.R., Fox T., Malarkey D.E., and Goldsworthy T.L. Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors. Toxicology 101 (1995) 125-156
-
(1995)
Toxicology
, vol.101
, pp. 125-156
-
-
Maronpot, R.R.1
Fox, T.2
Malarkey, D.E.3
Goldsworthy, T.L.4
-
4
-
-
0026092941
-
Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis
-
Buchmann A., Bauer-Hofmann R., Mahr J., Drinkwater N.R., Luz A., and Schwarz M. Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis. Proc. Natl. Acad. Sci. USA 88 (1991) 911-915
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 911-915
-
-
Buchmann, A.1
Bauer-Hofmann, R.2
Mahr, J.3
Drinkwater, N.R.4
Luz, A.5
Schwarz, M.6
-
5
-
-
0026100163
-
Incidence of mutations at codon 61 of the Ha-ras gene in liver tumors of mice genetically susceptible and resistant to hepatocarcinogenesis
-
Dragani T.A., Manenti G., Colombo B.M., Falvella F.S., Gariboldi M., Pierotti M.A., and Della Porta G. Incidence of mutations at codon 61 of the Ha-ras gene in liver tumors of mice genetically susceptible and resistant to hepatocarcinogenesis. Oncogene 6 (1991) 333-338
-
(1991)
Oncogene
, vol.6
, pp. 333-338
-
-
Dragani, T.A.1
Manenti, G.2
Colombo, B.M.3
Falvella, F.S.4
Gariboldi, M.5
Pierotti, M.A.6
Della Porta, G.7
-
6
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3 (2003) 11-22
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
7
-
-
0037805547
-
RAS oncogenes: the first 30 years
-
Malumbres M., and Barbacid M. RAS oncogenes: the first 30 years. Nat. Rev. Cancer 3 (2003) 459-465
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 459-465
-
-
Malumbres, M.1
Barbacid, M.2
-
8
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S., Shannon K., and Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer 7 (2007) 295-308
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
9
-
-
0038697566
-
Raf proteins and cancer: B-Raf is identified as a mutational target
-
Mercer K.E., and Pritchard C.A. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim. Biophys. Acta 1653 (2003) 25-40
-
(2003)
Biochim. Biophys. Acta
, vol.1653
, pp. 25-40
-
-
Mercer, K.E.1
Pritchard, C.A.2
-
11
-
-
33749635119
-
Raf kinases: oncogenesis and drug discovery
-
Schreck R., and Rapp U.R. Raf kinases: oncogenesis and drug discovery. Int. J. Cancer 119 (2006) 2261-2271
-
(2006)
Int. J. Cancer
, vol.119
, pp. 2261-2271
-
-
Schreck, R.1
Rapp, U.R.2
-
12
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J., Hargrave D., Pritchard Jones K., Maitland N., Chenevix Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A., Nicholson A., Ho J.W., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., and Futreal P.A. Mutations of the BRAF gene in human cancer. Nature 417 (2002) 949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard Jones, K.32
Maitland, N.33
Chenevix Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmieri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
13
-
-
10744232660
-
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors
-
Ikenoue T., Hikiba Y., Kanai F., Tanaka Y., Imamura J., Imamura T., Ohta M., Ijichi H., Tateishi K., Kawakami T., Aragaki J., Matsumura M., Kawabe T., and Omata M. Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. Cancer Res. 63 (2003) 8132-8137
-
(2003)
Cancer Res.
, vol.63
, pp. 8132-8137
-
-
Ikenoue, T.1
Hikiba, Y.2
Kanai, F.3
Tanaka, Y.4
Imamura, J.5
Imamura, T.6
Ohta, M.7
Ijichi, H.8
Tateishi, K.9
Kawakami, T.10
Aragaki, J.11
Matsumura, M.12
Kawabe, T.13
Omata, M.14
-
14
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan P.T., Garnett M.J., Roe S.M., Lee S., Niculescu Duvaz D., Good V.M., Jones C.M., Marshall C.J., Springer C.J., Barford D., and Marais R. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116 (2004) 855-867
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
Marais, R.11
-
15
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H., Bardelli A., Lengauer C., Kinzler K.W., Vogelstein B., and Velculescu V.E. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 418 (2002) 934
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
16
-
-
0037112438
-
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia
-
Yuen S.T., Davies H., Chan T.L., Ho J.W., Bignell G.R., Cox C., Stephens P., Edkins S., Tsui W.W., Chan A.S., Futreal P.A., Stratton M.R., Wooster R., and Leung S.Y. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res. 62 (2002) 6451-6455
-
(2002)
Cancer Res.
, vol.62
, pp. 6451-6455
-
-
Yuen, S.T.1
Davies, H.2
Chan, T.L.3
Ho, J.W.4
Bignell, G.R.5
Cox, C.6
Stephens, P.7
Edkins, S.8
Tsui, W.W.9
Chan, A.S.10
Futreal, P.A.11
Stratton, M.R.12
Wooster, R.13
Leung, S.Y.14
-
17
-
-
0037454224
-
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
-
Singer G., Oldt III R., Cohen Y., Wang B.G., Sidransky D., Kurman R.J., and Shih I.-M. Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J. Natl. Cancer Inst. 95 (2003) 484-486
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 484-486
-
-
Singer, G.1
Oldt III, R.2
Cohen, Y.3
Wang, B.G.4
Sidransky, D.5
Kurman, R.J.6
Shih, I.-M.7
-
18
-
-
14644436355
-
B-raf and Ha-ras mutations in chemically induced mouse liver tumors
-
Jaworski M., Buchmann A., Bauer P., Riess O., and Schwarz M. B-raf and Ha-ras mutations in chemically induced mouse liver tumors. Oncogene 24 (2005) 1290-1295
-
(2005)
Oncogene
, vol.24
, pp. 1290-1295
-
-
Jaworski, M.1
Buchmann, A.2
Bauer, P.3
Riess, O.4
Schwarz, M.5
-
19
-
-
0022792772
-
Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice
-
Drinkwater N.R., and Ginsler J.J. Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice. Carcinogenesis 7 (1986) 1701-1707
-
(1986)
Carcinogenesis
, vol.7
, pp. 1701-1707
-
-
Drinkwater, N.R.1
Ginsler, J.J.2
-
20
-
-
0027500318
-
Chromosome mapping of murine susceptibility loci to liver carcinogenesis
-
Gariboldi M., Manenti G., Canzian F., Falvella F.S., Pierotti M.A., Della Porta G., Binelli G., and Dragani T.A. Chromosome mapping of murine susceptibility loci to liver carcinogenesis. Cancer Res 53 (1993) 209-211
-
(1993)
Cancer Res
, vol.53
, pp. 209-211
-
-
Gariboldi, M.1
Manenti, G.2
Canzian, F.3
Falvella, F.S.4
Pierotti, M.A.5
Della Porta, G.6
Binelli, G.7
Dragani, T.A.8
-
21
-
-
0029559067
-
Genetics of liver tumor susceptibility in mice
-
Dragani T.A., Manenti G., Gariboldi M., De Gregorio L., and Pierotti M.A. Genetics of liver tumor susceptibility in mice. Toxicol Lett. 82-83 (1995) 613-619
-
(1995)
Toxicol Lett.
, vol.82-83
, pp. 613-619
-
-
Dragani, T.A.1
Manenti, G.2
Gariboldi, M.3
De Gregorio, L.4
Pierotti, M.A.5
-
22
-
-
0031955368
-
Cancer resistance genes in mice: models for the study of tumour modifiers
-
Balmain A., and Nagase H. Cancer resistance genes in mice: models for the study of tumour modifiers. Trends Genet. 14 (1998) 139-144
-
(1998)
Trends Genet.
, vol.14
, pp. 139-144
-
-
Balmain, A.1
Nagase, H.2
-
23
-
-
3142670509
-
A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines
-
Bilger A., Bennett L.M., Carabeo R.A., Chiaverotti T.A., Dvorak C., Liss K.M., Schadewald S.A., Pitot H.C., and Drinkwater N.R. A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. Genetics 167 (2004) 859-866
-
(2004)
Genetics
, vol.167
, pp. 859-866
-
-
Bilger, A.1
Bennett, L.M.2
Carabeo, R.A.3
Chiaverotti, T.A.4
Dvorak, C.5
Liss, K.M.6
Schadewald, S.A.7
Pitot, H.C.8
Drinkwater, N.R.9
-
24
-
-
0031594817
-
p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions
-
Kalkuhl A., Troppmair J., Buchmann A., Stinchcombe S., Buenemann C.L., Rapp U.R., Kaestner K., and Schwarz M. p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions. Hepatology 27 (1998) 1081-1088
-
(1998)
Hepatology
, vol.27
, pp. 1081-1088
-
-
Kalkuhl, A.1
Troppmair, J.2
Buchmann, A.3
Stinchcombe, S.4
Buenemann, C.L.5
Rapp, U.R.6
Kaestner, K.7
Schwarz, M.8
-
25
-
-
0024436733
-
Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse
-
Buchmann A., Mahr J., Bauer-Hofmann R., and Schwarz M. Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse. Mol. Carcinogen 2 (1989) 121-125
-
(1989)
Mol. Carcinogen
, vol.2
, pp. 121-125
-
-
Buchmann, A.1
Mahr, J.2
Bauer-Hofmann, R.3
Schwarz, M.4
-
26
-
-
33747877570
-
PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors
-
Strathmann J., Schwarz M., Tharappel J.C., Glauert H.P., Spear B.T., Robertson L.W., Appel K.E., and Buchmann A. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol. Sci. 93 (2006) 34-40
-
(2006)
Toxicol. Sci.
, vol.93
, pp. 34-40
-
-
Strathmann, J.1
Schwarz, M.2
Tharappel, J.C.3
Glauert, H.P.4
Spear, B.T.5
Robertson, L.W.6
Appel, K.E.7
Buchmann, A.8
-
27
-
-
0024236909
-
Oncogene activation in chemical carcinogenesis
-
Balmain A., and Brown K. Oncogene activation in chemical carcinogenesis. Adv. Cancer Res. 51 (1988) 147-182
-
(1988)
Adv. Cancer Res.
, vol.51
, pp. 147-182
-
-
Balmain, A.1
Brown, K.2
-
28
-
-
0025365695
-
Tissue-specific activating mutations of Ha- and Ki-ras oncogenes in skin, lung, and liver tumors induced in mice following transplacental exposure to DMBA
-
Loktionov A., Hollstein M., Martel N., Galendo D., Cabral J.R., Tomatis L., and Yamasaki H. Tissue-specific activating mutations of Ha- and Ki-ras oncogenes in skin, lung, and liver tumors induced in mice following transplacental exposure to DMBA. Mol. Carcinog. 3 (1990) 134-140
-
(1990)
Mol. Carcinog.
, vol.3
, pp. 134-140
-
-
Loktionov, A.1
Hollstein, M.2
Martel, N.3
Galendo, D.4
Cabral, J.R.5
Tomatis, L.6
Yamasaki, H.7
-
29
-
-
0026651941
-
Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice
-
Manam S., Storer R.D., Prahalada S., Leander K.R., Kraynak A.R., Ledwith B.J., van Zwieten M.J., Bradley M.O., and Nichols W.W. Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice. Cancer Res. 52 (1992) 3347-3352
-
(1992)
Cancer Res.
, vol.52
, pp. 3347-3352
-
-
Manam, S.1
Storer, R.D.2
Prahalada, S.3
Leander, K.R.4
Kraynak, A.R.5
Ledwith, B.J.6
van Zwieten, M.J.7
Bradley, M.O.8
Nichols, W.W.9
-
30
-
-
29244487538
-
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts
-
Mercer K., Giblett S., Green S., Lloyd D., DaRocha Dias S., Plumb M., Marais R., and Pritchard C. Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res. 65 (2005) 11493-11500
-
(2005)
Cancer Res.
, vol.65
, pp. 11493-11500
-
-
Mercer, K.1
Giblett, S.2
Green, S.3
Lloyd, D.4
DaRocha Dias, S.5
Plumb, M.6
Marais, R.7
Pritchard, C.8
-
31
-
-
0027457349
-
Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors
-
Storm S.M., and Rapp U.R. Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors. Toxicol. Lett. 67 (1993) 201-210
-
(1993)
Toxicol. Lett.
, vol.67
, pp. 201-210
-
-
Storm, S.M.1
Rapp, U.R.2
-
32
-
-
0037400510
-
Mechanisms of regulating the Raf kinase family
-
Chong H., Vikis H.G., and Guan K.L. Mechanisms of regulating the Raf kinase family. Cell Signal 15 (2003) 463-469
-
(2003)
Cell Signal
, vol.15
, pp. 463-469
-
-
Chong, H.1
Vikis, H.G.2
Guan, K.L.3
-
33
-
-
34248583886
-
MAP kinase signalling pathways in cancer
-
Dhillon A.S., Hagan S., Rath O., and Kolch W. MAP kinase signalling pathways in cancer. Oncogene 26 (2007) 3279-3290
-
(2007)
Oncogene
, vol.26
, pp. 3279-3290
-
-
Dhillon, A.S.1
Hagan, S.2
Rath, O.3
Kolch, W.4
-
34
-
-
7444245100
-
Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?
-
Repasky G.A., Chenette E.J., and Der C.J. Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?. Trends Cell Biol. 14 (2004) 639-647
-
(2004)
Trends Cell Biol.
, vol.14
, pp. 639-647
-
-
Repasky, G.A.1
Chenette, E.J.2
Der, C.J.3
-
35
-
-
34548056147
-
Global gene expression in Ha-ras and B-raf mutated mouse liver tumors
-
Jaworski M., Ittrich C., Hailfinger S., Bonin M., Buchmann A., Schwarz M., and Köhle C. Global gene expression in Ha-ras and B-raf mutated mouse liver tumors. Int. J. Cancer 121 (2007) 1382-1385
-
(2007)
Int. J. Cancer
, vol.121
, pp. 1382-1385
-
-
Jaworski, M.1
Ittrich, C.2
Hailfinger, S.3
Bonin, M.4
Buchmann, A.5
Schwarz, M.6
Köhle, C.7
-
36
-
-
0035936026
-
Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors
-
Aydinlik H., Nguyen T.D., Moennikes O., Buchmann A., and Schwarz M. Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene 20 (2001) 7812-7816
-
(2001)
Oncogene
, vol.20
, pp. 7812-7816
-
-
Aydinlik, H.1
Nguyen, T.D.2
Moennikes, O.3
Buchmann, A.4
Schwarz, M.5
-
37
-
-
3042697182
-
Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital
-
Calvisi D.F., Ladu S., Factor V.M., and Thorgeirsson S.S. Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital. Carcinogenesis 25 (2004) 901-908
-
(2004)
Carcinogenesis
, vol.25
, pp. 901-908
-
-
Calvisi, D.F.1
Ladu, S.2
Factor, V.M.3
Thorgeirsson, S.S.4
-
38
-
-
0029592653
-
Role of receptors in human and rodent hepatocarcinogenesis
-
Schwarz M., Buchmann A., Stinchcombe S., Luebeck G., Moolgavkar S., and Bock K.W. Role of receptors in human and rodent hepatocarcinogenesis. Mutat. Res. 333 (1995) 69-79
-
(1995)
Mutat. Res.
, vol.333
, pp. 69-79
-
-
Schwarz, M.1
Buchmann, A.2
Stinchcombe, S.3
Luebeck, G.4
Moolgavkar, S.5
Bock, K.W.6
-
39
-
-
0037624602
-
Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
-
Tannapfel A., Sommerer F., Benicke M., Katalinic A., Uhlmann D., Witzigmann H., Hauss J., and Wittekind C. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut 52 (2003) 706-712
-
(2003)
Gut
, vol.52
, pp. 706-712
-
-
Tannapfel, A.1
Sommerer, F.2
Benicke, M.3
Katalinic, A.4
Uhlmann, D.5
Witzigmann, H.6
Hauss, J.7
Wittekind, C.8
-
40
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat. Rev. Mol. Cell Biol. 6 (2005) 827-837
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 827-837
-
-
Kolch, W.1
|