Haemonchus contortus-sheep relationship: A review

Revista Cientifica de la Facultad de Ciencias Veterinarias de la Universidad del Zulia

Volumn 17, Issue 6, 2007, Pages 577-587

  Angulo Cubillán, Francisco J ^a,b   García Coiradas, Leticia ^a   Cuquerella, Montserrat ^a   De La Fuente, Concepción ^a   Alunda, José M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD DEL ZULIA   (Venezuela)

Author keywords

Haemonchosis; Haemonchus contortus; Immune response; Pathophysiology; Sheep

Indexed keywords

ANIMALIA; BOVIDAE; HAEMONCHUS CONTORTUS; OVIS ARIES; VERMES;

EID: 37749037152     PISSN: 07982259     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (132)

1. ABBAS, A.K.; LICHTMAN, A.H. Maduración, activación y regulación de los linfocitos. Immunología celular y molecular. Elsevier España S.A. Madrid, España. 149-153 pp. 2004.
2. ACHI, Y.L.; ZINSSTAG, J.; YAO, K.; YEO, N.; DORCHIES, P.; JACQUIET, P. Host specificity of Haemonchus spp. for domestic rumminants in the savanna in northern Ivory Coast. Vet. Parasitol. 116: 151-158. 2003.
3. ALUNDA, J.M.; ANGULO-CUBILLÁN, F.; CUQUERELLA, M. Immunization against ovine haemonchosis with three low molecular weight somatic antigens of adult Haemonchus contortus. J. Vet. Med. S. B. 50 (2): 70-74. 2003.
4. AMARANTE, A.F.T.; CRAIG, T.M.; RAMSEY, W.S.; DAVIS, S.K.; BAZER, F.W. Nematode burdens and cellular responses in the abomasal mucosa and blood of Florida native, Rambouillet and crossbreed lambs. Vet. Parasitol. 80: 311-324. 1999.
5. AMARANTE, A.F.T.; BRICARELLO, P.A.; HUNTLEY, J.F.; MAZZOLIN, L.P.; GOMES, J.C. Relationship of abomasal histology and parasite-specific immunoglobulin A with the resistance to Haemonchus contortus infection in three breeds of sheep. Vet. Parasitol. 128: 99-107. 2005
6. ANDREWS, S.J.; ROLPH, T.P.; MUNN, E.A.; TAYLOR, M.A. Duration of protective immunity against ovine haemonchosis following vaccination with the nematode gut membrane antigen H11. Res. Vet. Sci. 62: 223-227. 1997.
7. AUMONT, G.; GRUNER, L.; HOSTACHE, G. Comparison of the resistence to sympatric and allopatric isolates of Haemonchus contortus of Black Belly sheep in Guadalupe (FWI) and INRA 401 sheep in France. Vet. Parasitol. 116: 139-150. 2003.
8. BAKER, R.L.; NAGDA, S.; RODRIGUEZ-ZAS, S.L.; SOUTHEY, B.R.; AUDHO, J.O.; ADUDA, E.O.; THORPE, W. Resistance and resilience to gastro-intestinal nematode parasites and relationships with productivity of Red Massai, Dorper and Red Massai X Dorper crossbred lambs in the sub-humid tropics. Anim. Sci. 76: 119-136. 2003.
9. BAKKER, N.; VERVELDE, L.; KANOBANA, K.; KNOX, D.P.; CORNELISSEN, A.W.C.A.; DE VRIES, E.; YATSUDA, A.P. Vaccination against the nematodo Haemonchus contortus with a tilo-binding fraction from the excretory/secretory products (ES). Vacc. 22: 618-628. 2004.
10. BALIC, A.; BOWLES, V.M.; MEEUSEN, E.N.T. The immunobiology of gastrointestinal nematode infections in ruminants. Adv. Parasitol. 45: 181-241. 2000a.
11. BALIC, A.; BOWLES, V.M.; MEEUSEN, E.N.T. Cellular profiles in the abomasal mucosa and lymph node during primary infection with Haemonchus contortus in sheep. Vet. Immunol. Immunopathol. 75: 109-120. 2000b.
12. BARGER, I.A.; DASH, K.M. Repeatibility of ovine faecal egg counts and blood packed cell volumes in Haemonchus contortus infections. Int. J. Parasitol. 17 (4): 977-980. 1987.
13. BEHM, C.A.; OVINGTON, K.S. The role of eosinophils in parasitic helminth infections: Insights from genetically modified mice. Parasitol. Today. 16 (5): 202-209. 2000.
14. BENDIXSEN, T.; EMERY, D.L.; JONES, W.O. The sensitization of mucosal mast cells during infections with Trichostrongylus colubriformis or Haemonchus contortus in sheep. Int. J. Parasitol. 25 (6): 741-748. 1995.
15. BEREZHKO, V.K.; AKULIN, N.A.; BUZMAKOVA, R.A.; KUROCHKINA, K.G. Immunoallergic reactions and a phenomenon of self-cure in experimental haemonchosis (Haemonchus contortus) of sheep depending on host's age. Helminthol. 24: 119-131. 1987.
16. BOISVENUE, R.J.; STIFF, M.I.; TONKINSON, L.V.; COX, G.N. Protective studies in sheep immunised with cuticular collagen proteins and peptides of Haemonchus contortus. Par. Immunol. 13: 227-240. 1991.
17. BRICARELLO, P.A.; GENNARI, S.M.; OLIVEIRA-SEQUEIRA, T.C.G.; VAZ, C.M.S.L.; GONCALVES DE G., I.; ECHEVARRIA, F.A.M. Worm burden and immunological responses in Corriedale and Crioula Lanada sheep following natural infection with Haemonchus contortus. S. Rum. Res. 51: 75-83. 2004.
18. BURKE, J.M.; MILLER, J.E. Relative resistance of Dorper crossbred ewes to gastrointestinal nematode infection compared with St. Croix and Katahdin ewes in the southeastern United States. Vet. Parasitol. 109: 265-275. 2002.
19. CAPITINI, L.A.; MCCLURE, K.E.; HERD, R.P. Effect of environmental stimuli on pre-infective and infective stages of Haemonchus contortus in the Northern United States for the induction of hypobiosis. Vet. Parasitol. 35: 281-293. 1990.
20. CLAEREBOUT, E.; VERCRUYSSE, J. The immune response and the evaluation of acquired immunity against gastrointestinal nematodes in cattle: a review. Parasitol. 120: S25-S42. 2000.
21. COBON, D.H.; O'SULLIVAN, B.M. Effect of Haemonchus contortus on productivity of ewes, lambs and weaners in a semi-arid environment. J. Agr. Sci. 118: 245-248. 1992.
22. COLLINS, R.A.; SOPP, P.; PARSONS, K.R.; MORRISON, W.I.; HOWARD, C.J. What are the cells and molecules involved in stimulating bovine γ/δ T cells? Vet. Immunol. Immunopathol. 54: 93. 1996.
23. COOP, R.L.; KYRIAZAKIS, L. Nutrition-parasite interaction. Vet. Parasitol. 84 (3-4): 187-204. 1999.
24. COOP, R.L.; KYRIAZAKIS, L. Influence of host nutrition on the development and consequences of nematode parasitism in ruminants. Trends Parasitol. 17: 325-330. 2001.
25. CUQUERELLA, M.; GÓMEZ-MUÑOZ, M.T.; ALUNDA, J.M. Serum IgG response of Manchego lambs to infections with Haemonchus contortus and preliminary characterization of adult antigens. Vet. Parasitol. 38: 131-143. 1991.
26. CUQUERELLA, M.; GÓMEZ-MUÑOZ, M.T.; MÉNDEZ, S.; ALUNDA, J.M. Partial protection of Manchego sheep against Haemonchus contortus after a 6-month post-priming period. Preliminary note. J. Vet. Med. B. 41: 399-406. 1994a.
27. CUQUERELLA, M.; GÓMEZ-MUÑOZ, M.T.; CARRERA, L.; DE LA FUENTE, C.; ALUNDA, J.M. Croos anti-genicity among ovine trichosntrongyloidea. Preliminary Report. Vet. Parasitol. 53: 243-251. 1994b.
28. DASH, K.M. Distribution of trichostrongylid nematodes in the abomasum of sheep. Int. J. Parasitol. 15: 505-510. 1985.
29. DOMÍNGUEZ-TORAÑO, I.A.; CUQUERELLA, M.; GOMEZ-MUÑOZ, M.T.; MÉNDEZ, S.; ALUNDA, J.M. Vaccination of Manchego lambs against Haemonchus contortus with a somatic fraction (p26/23) of adult parasites. Parasitol. Immunol. 22: 131-138. 2000.
30. DOMÍNGUEZ-TORAÑO, I.A.; FERNÁNDEZ-PÉREZ, F.J.; GOMEZ-MUÑOZ, M.T.; ALUNDA, J.M.; CUQUERELLA, M. Humoral and cellular response in lambs vaccinated against Haemonchus contortus with p26/23. S. Rum. Res. 50: 29-37. 2003.
31. DORNY, P.; VERCRUYSSE, J. Evaluation of a micro method for the routine determination of serum pepsinogen in cattle. Res. Vet. Sci. 65: 259-262. 1998.
32. DURETTE-DESSET, M.C.; HUGOT, J.P.; DARLU, P.; CHABAUD, A.G. A cladistic analysis of the Trichostrongyloidea (Nematoda). Int. J. Parasitol. 29: 1065-1086. 1999.
33. EYSKER, M.; PLOEGER, H.W. Value of present diagnostic methods for gastrointestinal nematode infections in ruminants. Parasitol. 120: S109-S119. 2000.
34. FAKAE, B.B.; CHIEJINA, S.N.; BEHNKE, J.M.; EZEOK-ONKWO, R.C.; NNADI, P.A.; ONYENWE, W.I.; GILBERT, F.S.; WAKELIN, D. The response of Nigerian West African Dwarf goats to experimental infections with Haemonchus contortus. Res. Vet. Sci. 66: 147-158. 1999.
35. FALCONE, F.H.; PRITCHARD, D.I.; GIBBS, B.F. Do basophils play a role in immunity against parasites? Trends Parasitol. 17 (3): 126-129. 2001.
36. FETTERER, R.H.; RHOADS, M.L. Characterization of haemolytic activity from adult Haemonchus contortus. Int. J. Parasitol. 27 (9): 1037-1040. 1997.
37. FETTERER, R.H.; RHOADS, M.L. A haemolytic factor from Haemonchus contortus alters erythrocyte morphology. Vet. Parasitol. 80: 37-45. 1998.
38. FOX, M.T.; PITT, S.R.; GERRELLI, D.; JACOBS, D.E.; ADHIKARI, D.R.; GODDARD, P.J. Use of blood gastrin assay in the diagnosis of ovine haemonchiasis. Vet. Rec.122: 136-137. 1988.
39. FOX, M.T.; JACOBS, D. E. Blood gastrin and pepsinogen responses of native village goats in Malaysia to in-fection with Haemonchus contortus. Ann. Trop. Med. Parasitol. 85: 263-267. 1991.
40. FOX, M.T. Pathophysiology of infection with gastrointestinal nematodes in domestic ruminants: recent developments. Vet. Parasitol. 72: 285-308. 1997.
41. GATONGI, P.M.; PRICHARD, R.K.; RANJAN, S.; GATHUMA, J.M.; MUNYUA, W.K.; CHERUIYOT, H.; SCOTT, M.E. Hypobiosis of Haemonchus contortus in natural infections of sheep ang goats in a semi-arid area of Kenya. Vet. Parasitol. 77:49-61. 1998.
42. GILL, H.S. Genetic control of acquired resistance to haemonchosis in Merino lambs. Parasitol. Immunol. 13: 617-628. 1991.
43. GILL, H.S.; WATSON, D.L.; BRANDON, M.R. Monoclonal antibody to CD4+ T cells abrogates genetic resistance to Haemonchus contortus in sheep. Immunol. 78: 43-49. 1993.
44. GÓMEZ-MUÑOZ, M.T.; CUQUERELLA, M.; DE LA FUENTE, C.; GÓMEZ-IGLESIAS, L.A.; ALUNDA, J.M. Infection-induced protection against Haemonchus contortus in Merino and Manchego sheep. Relationship to serum antibody response. J. Vet. Med. B. 45:449-459. 1998.
45. GÓMEZ-MUÑOZ, M.T.; CUQUERELLA, M.; GÓMEZ-IGLESIAS, L.A.; MÉNDEZ, S.; FERNÁNDEZ-PÉREZ, F.J.; DE LA FUENTE, C.; ALUNDA, J.M. Serum antibody response of Castellana sheep to Haemonchus contortus infection and challenge: relationship to abomasal worm burdens. Vet. Parasitol. 81: 281-293. 1999.
46. GÓMEZ-MUÑOZ, M.T.; GÓMEZ-IGLESIAS, L.A.; FERNÁNDEZ-PÉREZ, F.J.; MÉNDEZ, S.; DOMÍNGUEZ, I.A.; DE LA FUENTE, C.; ALUNDA, J.M.; CUQUERELLA, M. Experimental Haemonchus contortus infection and challenge in the Churra sheep breed: immunological and pathophysiological parameters. Rev. Ibér. Parasitol. 61:83-89. 2001.
47. GOUŸ DE B., J.; FERTE, H.; DEPAQUIT, J.; JUSTINE, J.L.; TILLIER, A.; DURETTE-DESSET, M.C. Phytogeny of the Trichostrongylina (Nematoda) inferred from 28s rDNA sequences. Mol. Phylogenet. Evolut. 19 (3): 430-442. 2001.
48. HARTMANN, S.; LUCIUS, R. Modulation af host immune responses by nematode cystatins. Int. J. Parasitol. 33: 1291-1302. 2003.
49. HERTZBERG, H.; GUCETTI, F.; LISCHER, C.; KOHLER, L.; NEIGER, R.; ECKERT, J. Evidence for a parasite-mediated inhibition of abomasal acid secretion in sheep infected with Ostertagia leptospicularis. Vet. J. 159:238-251. 2000.
50. HOBER, E.; LICHTENFELS, J.; GIBBONS, L. Phylogeny for species of the genus Haemonchus (Nematoda: Trichostrongyloidea): Considerations of their evolutionary history and global biogeography among Camelidae and Pecora (Artiodactyla). J. Parasitol. 90 (6): 1378-1386. 2004.
51. HOWARD, C.J.; BROOKE, G.P.; WERLING, D.; SOPP, P.; HOPE, J.C.; PARSONS, K.R.; COLLINS, R.A. Dendritic cells in cattle: phenotype and function. Vet. Immunol. Immunopathol. 72. 119-124. 1999.
52. HUNTER, A.R.; MACKENZIE, G. The pathogenesis of a single challenge dose of Haemonchus contortus in lambs under six months of age. J. Helminthol. 56: 135-144. 1982.
53. HUNTLEY, J.F.; NEWLANDS, G.; MILLER, H.R.P. The isolation and characterization of globule leucocytes: their derivation from mucosal mast cells in parasitized sheep. Parasitol. Immunol. 6: 371-390. 1984.
54. HUNTLEY, J.F.; JACKSON, F.; COOP, R.L.; MACAL-DOWIE, C.; HOUDIJK, J.G.M.; FAMILTON, A.S.; XIEH, H.L.; STANKIEWICZ, M.; SYKES, A.R. The sequential analysis of local inflammatory cells during abomasal nematode infection in periparturient sheep. Vet. Immunol. Immunopathol. 97: 163-176. 2004.
55. JACQUIET, PH.; CABARET, J.; CHEIKH, D.; THIAM, E. Identification of Haemonchus species in domestic ruminants based on morphometrics of spicules. Parasitol. Res. 83: 82-86. 1997.
56. JACOBS, H.J.; ASHMAN, K.; MEEUSEN, E. Humoral and cellular responses following local immunization with a surface antigen of the gastrointestinal parasite Haemonchus contortus. Met. Immunol. Immunopathol. 48: 323-332. 1995.
57. JACOBS, H.J.; WILTSHIRE, C.; ASHMAN, K.; MEEUSEN, E.N.T. Vaccination against the gastrointestinal nematode, Haemonchus contortus, using a purified larval surface antigen. Vacc. 17: 362-368. 1999.
58. KABAGAMBE, E.K.; BARRAS, S.R.; LI, Y.; PEÑA, M.T.; SMITH, W.D.; MILLER, J.E. Attempts to control haemonchosis in grazing ewes by vaccination with gut membrane proteins of the parasite. Vet. Parasitol. 92: 15-23. 2000.
59. KARANU, F.N.; MCGUIRE, T.C.; DAVIS, W.C.; BESSER, T.E.; JASMER, D.P. CD4+ T lymphocytes contribute to protective immunity induced in sheep and goats by Haemonchus contortus gut antigens. Parasitol. Immunol. 19: 435-445. 1997.
60. KASSAI, T. Clasificación de helmintos parásitos. Helmintología Veterinaria. Ed. Acribia S.A. Zaragoza, España. XXIII-XXVIII pp. 2002.
61. KAUFMANN, J. Parasites of sheep and goats. Parasitic infections of domestic animals. A diagnostic manual. Berlin: Birkhäuser. 37-39 pp. 1996.
62. KERBOEUF, D.; KOCH, C.; LE DREAN ET, E.; LACOURT, A. Méthode simplifiée de mesure de la concentration en pepsinogéne dans le sérum. Rev. Méd. Vét. 153: 707-712. 2002.
63. KHAN, M.Q.; HAYAT, S.; HUSSAIN, M.I.M.; IQBAL, Z. Effect of haemonchosis on body weigth gain and values in sheep. Pak. Vet. J. 8 (2): 62-67. 1988.
64. KLION, A.D.; NUTMAN, T.B. The role of eosinophils in host defense against helminth parasites. J. Allerg. Clinic. Immunol. 113 (1): 30-37. 2004.
65. KNOX, M.R.; STEEL, J.W. The effects of urea supplementation on production and parasitological responses of sheep infected with Haemonchus contortus and Trichostrongylus colubriformis. Vet. Parasitol. 83: 123-135. 1999.
66. KNOX, D.P.; SMITH, S.K.; SMITH, W.D. Immunization with an affinity purified protein extract from the adult parasite protects lambs against infection with Haemonchus contortus. Parasitol. Immunol. 21: 201-210. 1999.
67. KNOX, D.P.; SMITH, W.D. Vaccination against gastrointestinal nematode parasites of ruminants using gut-expressed antigens. Vet. Parasitol. 100: 21-32. 2001.
68. KOOYMAN, F.N.J.; SCHALLIG, H.D.F.H.; VAN LEEUWEN, M.A.W.; MACKELLAR, A.; HUNTLEY, J.F.; CORNELISSEN, A.W.C.A.; VERVELDE, L. Protection in lambs vaccinated with Haemonchus contortus antigens is age related, and correlates with IgE rather than IgG1 antibody. Parasitol. Immunol. 22: 13-20. 2000.
69. LE JAMBRE, L.F. Relationship of blood loss to worm numbers, biomass and egg production in Haemonchus infected sheep. Int. J. Parasitol. 25: 269-273. 1995.
70. LICHTENFELS, J.R.; PILITT, P.A.; HOBERG, E.P. New morphological characters for identifying individual specimens of Haemonchus spp. (Nematoda: Trichostrongyloidea) and key to species in ruminants of north America. J. Parasitol. 80: 107-119. 1994.
71. LICHTENFELS, J.R.; PILITT, P.A.; GIBBONS, L.M.; BOOMKER, J.D. Haemonchus horaki n. Sp. (Nematoda: Trichostrongyloidea) from the grey rhebuck Pelea capreolus in South Africa. J. Parasitol. 87 (5): 1095-1103. 2001.
72. LONDON, C.A.; ABBAS, A.K.; KELSO, A. Helper T cell subsets: Heterogeinity, functions and development. Vet. Immunol. Immunopathol. 63: 37-44. 1998.
73. LOUKAS, A.; MAIZELS, R.M. Helminth C-type lectins and host-parasite interactions. Parasitol. Today. 16 (8): 333-339. 2000.
74. MACALDOWIE, C.; JACKSON, F.; HUNTLEY, J.; MACKELLAR, A.; JACKSON, E. A comparison of larval development and mucosal mast cell responses in worm-naïve goat yearling, kids and lambs undergoing primary and secondary challenge with Teladorsagia circumcincta. Vet. Parasitol. 114: 1-13. 2003.
75. McCLURE, S.J.; DAVEY, R.L.; EMERY, D.L.; COLDITZ, I.G.; LLOYD, J.B. In vivo depletion of T-cells and cytokines during primary exposure of sheep to parasites. Vet. Immunol. Immunopathol. 54: 83-90. 1996.
76. McCLURE, S.J.; EMERY, D.L.; BENDIXSEN, T.; DAVEY, R.J. Attempts to generate immunity against Trichostrongylus colubriformis and Haemonchus contortus in young lambs by vaccination with viable parasites. Int. J. Parasitol. 28: 739-746. 1998.
77. McKELLAR, Q.A. Interactions of Ostertagia species with their bovine and ovine host. Int. J. Parasitol. 23: 451-462. 1993.
78. MEEUSEN, E.N.T. Immunology of helminth infections, with special reference to immunopathology. Vet. Parasitol. 84: 259-273. 1999.
79. MEEUSEN, E.N.T.; BALIC, A. Do eosinophils have a role in the killing of helminth parasites? Parasitol. Today. 16 (3): 95-101. 2000.
80. MERKELBACH, P.; SCOTT, I.; KHALAF, S.; SIMPSON, H.V. Excretory/Secretory products of Haemonchus contortus inhibit aminopyrine accumulation by rabbit gastric glands in vitro. Vet. Parasitol. 104: 217-228. 2002.
81. MULCAHY, G.; O'NEILL, S.; DONNELLY, S.; DALTON, J.P. Helminths at mucosal barriers-interaction with the immune system. Adv. Drug Deliv. Rev. 56: 853-868. 2004.
82. MUNN, E.A. Rational design of nematode vaccine: hidden antigens. Int. J. Parasitol. 27 (4): 359-366. 1987.
83. MUNN, E.A.; GREENWOOD, C.A.; COADWELL, W.J. Vaccination of young lambs by means of a protein fraction extracted from adult Haemonchus contortus. Parasitol. 385-397. 1987.
84. NEWTON, S.E.; MORRISH, L.E.; MARTIN, P.J.; MONTAGUE, P.E.; ROLPH, T.P. Protection against multiply drug-resistant and geographically distant strains of Haemonchus contortus by vaccination with H11, a gut membrane-derived protective antigen. Int. J. Parasitol. 25 (4): 511-521. 1995.
85. NOTTER, D.R.; ANDREW, S.A.; ZAJAC, A.M. Responses of hair and wool sheep to a single fixed dose of infective larvae of Haemonchus contortus. S. Rum. Res. 47: 221-225. 2003.
86. ONYIAH, L.C.; ARSLAN, O. Simulating the development period of a parasite of sheep on pasture under varying temperature conditions. J. Thermal Biol. 30: 203-211. 2005.
87. PEÑA, M.T.; MILLER, J.E.; HOROHOV, D.W. Effect of dexamethasone treatment on the immune response of Gulf Cosat Native lambs to Haemonchus contortus infection. Vet. Parasitol. 119 (2-3): 223-235. 2004.
88. PÉREZ, J.; GARCÍA, P.M.; HERNÁNDEZ, S.; MARTÍNEZ-MORENO, A.; DE LAS MULAS, J.M.; CÁMARA, S. Pathological and immunohistochemical study of the abomasum and abomasal lymph nodes in goats experimentally infected with Haemonchus contortus. Vet. Res. 32: 463-473. 2001.
89. PÉREZ, J.; GARCÍA, P.M.; HERNÁNDEZ, S.; MOZOS, E.; CÁMARA, S.; MARTÍNEZ-MORENO, A. Experimental haemonchosis in goats: effects of single and multiple infections in the host response. Vet. Parasitol. 111: 333-342. 2003.
90. PEERSON-WALLER, K.; COLDITZ, I.G. Expression of surface antigen on blood and mammary leukocytes in lactating and dry ewes. Vet. Immunol. Immunopathol. 62: 273-278. 1998.
91. QUIROZ, R.H. Estrongilosis gastroentéricas. Parasitologí a y enfermedades parasitarias de los animales domésticos. 2° Ed. Ed. Limusa, S.A., México. 430-458 pp. 1999.
92. RAHMAN, W.A.; COLLINS, G.H. The establishment and development of Haemonchus contortus in goats. Vet. Parasitol. 35: 189-193. 1990.
93. REDMOND, D.L.; GELDHOF, P.; KNOX, D.P. Evaluation of Caenorhabditis elegans glycoproteins as protective immunogens against Haemonchus contortus challenge in sheep. Int. J. Parasitol. 34: 1347-1353. 2004.
94. REDMOND, D.L.; KNOX, D.P. Protection studies in sheep using affinity-purified and recombinant cysteine proteinases of adult Haemonchus contortus. Vacc. 22: 4252-4261. 2004.
95. ROWE, J.B.; NOLAN, J.V.; DE CHANEET, G.; TELENI, E. The effect of haemonchosis and blood loss into the abomasum on digestion in sheep. Brit. J. Nut. 59: 125-139. 1988.
96. SALMAN, S.K.; DUNCAN, J.L. The abomasal histology of worm free sheep given primary and challenge infections of Haemonchus contortus. Vet. Parasitol. 16: 43-54. 1984.
97. SANGSTER, N.C. Introduction to Symposium on Recent Research on Haemonchus contortus. Int. J. Parasitol. 25: 1271-1272. 1995.
98. SCHALLIG, H.D.F.H.; LEEUWEN, M.A.W.; HENDRIKX, W.M.L. Immune response of Texel sheep to excretory/secretory products of adult Haemonchus contortus. Parasitol. 108: 351-357. 1994.
99. SCHALLIG, H.D.F.H.; VAN LEEUWEN, M.A.W.; CORNELISSEN, W.C.A. Protective immunity induced by vaccination with two Haemonchus contortus excretory secretory proteins in sheep. Parasitol. Immunol. 19: 447-453. 1997.
100. SCHALLIG, H.D.F.H. Immunological responses of sheep to Haemonchus contortus. Parasitol. 120: S63-S72. 2000.
101. SCHALLIG, H.D.F.H.; VAN DER AAR, W.M.; BOERSEMA, J.H.; CORNELISSEN, A.W.C.A. The effect of oxfendazole terminated infections with Haemonchus contortus on the development of immunity in sheep. Vet. Parasitol. 88: 61-72. 2000.
102. SCOTT, I.; DICK, A.; IRVINE, J.; STEAR, M.J.; McKELLAR, Q.A. The distribution of pepsinogen within the abomasa of cattle and sheep infected with Ostertagia spp. and sheep infected with Haemonchus contortus. Vet. Parasitol. 82: 145-159. 1999.
103. SCOTT, I.; KHALAF, S.; SIMCOCK, D.C.; KNIGHT, C.G.; REYNOLDS, G.W.; POMROY, W.E.; SIMPSON, H.V. A sequential study of the pathology associated with the infection of sheep with adult and larval Ostertagia circumcincta. Vet. Parasitol. 89: 79-94. 2000.
104. SHER, A. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Ann. Rev. Immunol. 10: 385-409. 1992.
105. SIMCOCK, D.C.; JOBLIN, K.N.; SCOTT, I.; BURGESS, D.M.; ROGERS, C.W.; POMROY, W.E.; SIMPSON, H.V. Hypergastrinaemia, abomasal bacterial population densities and pH in sheep infected with Ostertagia circumcincta. Int. J. Parasitol. 29: 1053-1063. 1999.
106. SIMPSON, H.V. Pathophysiology of parasitism abomasal: is the host or parasite responsible? Vet. J. 160: 177-191. 2000.
107. SMITH, H.E.; JACOBS, R.M.; SMITH, C. Flow cytometric analysis of ovine peripheral blood lymphocytes. Can. J. Vet. Res. 58: 152-155. 1994.
108. SMITH, S.K.; SMITH, W.D. Immunisation of sheep with a integral membrane glycoprotein complex of Haemonchus contortus and with its major polypeptide components. Res. Vet. Sci. 60: 1-6. 1996.
109. SMITH, W.D. Protection in lambs immunised with Haemonchus contortus gut membrane proteins. Res. Vet. Sci. 54: 94-101. 1993.
110. SOULSBY, E.J.L. Género: Haemonchus Cobb, 1898. Parasitología y enfermedades parasitarias en los animales domésticos. 7° Ed. Interamericana S.A. México. 232-238 pp. 1987.
111. STEAR, M.J.; BAIRDEN, K.; DUNCAN, J.L.; MURRAY, M. A comparison of the responses to repeated experimental infections with Haemonchus contortus among Scottish Blackface lambs. Vet. Parasitol. 60: 69-81. 1995.
112. STEAR, M.J.; STRAIN, S.; BISHOP, S.C. Mechanisms underlying resistence to nematode infection. Int. J. Parasitol. 29: 51-56. 1999a.
113. STEAR, M.; BAIRDEN, K.; McKELLAR, Q.A.; SCOTT, I.; STRAIN, S.; BISHOP, S. The relationship between the number and size of nematodes in the abomasums and the concentration of pepsinogen in ovine plasma. Res. Vet. Sci. 67: 89-92. 1999b.
114. STEAR, M.J.; HENDERSON, N.G.; KERR, A.; McKELLAR, Q.A.; MITCHELL, S.; SEELEY, C.; BISHOP, S.C. Eosinophilia as a marker of resistence to Teladorsagia circumcincta in Scottish Blackface lambs. Parasitol. 124: 553-560. 2002.
115. STEVENSON, L.M.; HUNTLEY, J.F.; SMITH, W.D.; JONES, D.G. Local eosinophil and mast cell related responses in abomasal nematode infections of lambs. Immunol. Med. Microbiol. 8: 167-174. 1994.
116. STRAIN, S.A.; STEAR, M.J. The influence of protein supplementation on the immune response to Haemonchus contortus. Parasitol. Immunol. 23: 527-531. 2001.
117. SUAREZ, V.H.; LORENZO, R.M.; BUSETTI, M.R.; SANTUCHO, G.M. Physiological and parasitological responses to nematode infections of fattening cattle in the Western Pampas of Argentina. Vet. Parasitol. 81: 137-148. 1999.
118. SUCHITRA, S.; JOSHI, P. Characterizations of Haemonchus contortus calreticulin suggests its role in feeding and immune evasion by the parasite. Bioch. Bioph. Acta. 1722: 293-303. 2005.
119. TORGERSON, P.R.; LLOYD, S. The B cell dependence of Haemonchus contortus antigen induced lymphocyte proliferation. Int. J. Parasitol. 23 (7): 925-930. 1993a.
120. TORGERSON, P.R.; LLOYD, S. The same fractions of Haemonchus contortus soluble antigen induce lymphocyte responses in naive lambs and immune sheep. Res. Vet. Sci. 54: 244-246. 1993b.
121. TUO, W.; BAZER, F.W.; DAVIS, W.C.; ZHU, D.; BROWN, W.C. Differential effects to type I IFNs on the growth of WC1- CDS+ γδ T cells and WC1 + CD8 - γδ T cells in vitro. J. Immunol. 162: 245-253. 1999.
122. URQUHART, G.M.; JARRETT, W.F.H.; JENNINGS, F.W.; McINTYRE, W.I.M.; MULLIGAN, W. Immunity to Haemonchus contortus infection: Relationship between age and successful vaccination with irradiated larvae. Am. J. Vet. Res. 27 (121): 1645-1648. 1966.
123. URQUHART, G.M.; ARMOUR, J.; DUNCAN, J.L.; DUNN, A.M.; JENINGS, F.W. Veterinary Helminthology. Veterinary Parasitology. 2° Ed. Blackwell Science Ltd. London. UK. 19-22 pp. 2001.
124. VALDERRÁBANO, J.; DELFA, R.; URIARTE, J. Effect of level of feed intake on the development of gastrointestinal parasitism in growing lambs. Vet. Parasitol. 104: 327-338. 2002.
125. VALDERRÁBANO, J.; URIARTE, J. Effect of nutrition in early pregnancy on the periparturient relaxation of immunity to gastro-intestinal parasitism in prolific ewes. Anim. Sci. 76: 481-489. 2003.
126. VERVELDE, L.; KOOYMAN; F.N.J.; VAN LEEUWEN, M.A.W.; SCHALLIG, H.D.F.H.; McKELLAR, A.; HUNTLEY, J.F.; CORNELISSEN, A.W.C.A. Age related protective immunity after vaccination with Haemonchus contortus excretory/secretory proteins. Parasitol. Immunol 23:419-426. 2001.
127. WALLACE, D.S.; BAIRDEN, K.; DUNCAN, J.L.; FISHWICK, G.; GILL, M.; HOLMES, P.H.; McKELLAR, Q.A.; MURRAY, M.; PARKINS, J.J.; STEAR, M. Influence of supplementation with dietary soyabean meal on the resistance to haemonchosis in Hampshire down lambs. Res. Vet. Sci. 58: 232-237. 1995.
128. WALLACE, D.S.; BAIRDEN, K.; DUNCAN, J.L.; FISHWICK, G.; GILL, M.; HOLMES, P.H.; McKELLAR, Q.A.; MURRAY, M.; PARKINS, J.J.; STEAR, M. Influence of soyabean meal supplementation on the resistance of Scottish Blackface lambs to haemonchosis. Res. Vet. Sci. 60: 138-143. 1996.
129. WALLER, P.J. International approaches to the concept of integral control of nematode parasites of livestock. Int. J. Parasitol. 29: 155-164. 1999.
130. WILLIAMSON, A.L.; BRINDLEY, P.J.; KNOX, D.P.; HOTEZ, P.J.; LOUKAS, A. Digestive proteases of blood-feeding nematodes. Trends Parasitol. 19 (9): 417-423. 2003.
131. YACOOB, A.; HOLMES, P.H.; ARMOUR, J. Pathophisiology of gastrointestinal trichostrongyles in sheep: plasma losses and changes in plasma pepsinogen levels associated with parasitic challenge of immune animals. Res. Vet. Sci. 34: 305-309. 1983.
132. YONG, W.K.; EDWARDS, L.D.; HUCKER, D.A. Peripheral blood white cell responses during concurrent copper deficiency and gastro-intestinal nematodiasis in sheep. Exp. Biol. Med. Sci. 63: 273-281. 1985.