Cardiac carbon 13 magnetic resonance spectroscopy: On the horizon or over the rainbow?

Journal of Nuclear Cardiology

Volumn 9, Issue 4, 2002, Pages 419-428

  Lewandowski, E Douglas ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; RADIOISOTOPE;

ANIMAL EXPERIMENT; ARTICLE; BIOMEDICAL TECHNOLOGY ASSESSMENT; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; ECHOCARDIOGRAPHY; HEART MUSCLE METABOLISM; INTERMETHOD COMPARISON; MEDICAL TECHNOLOGY; METHODOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RADIATION DETECTION;

EID: 0036657127     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1067/mnc.2002.125811     Document Type: Article

References (63)

1. Lewandowski ED. Metabolic mechanisms associated with antianginal therapy. Circ Res 2000;86:487-89.
2. Lewandowski ED, Johnston DL, Roberts R. Effects of inosine on glycolysis and contracture during myocardial ischemia. Circ Res 1991;68:578-87.
3. Czernin J, Porenta G, Brunken R, Krivokapich J, Chen K, Bennett R, et al. Regional blood flow, oxidative metabolism, and glucose utilization in patients with recent myocardial infarction. Circulation 1993;88:884-95.
4. (31)P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans. MAGMA 2001;13:70-5.
5. Schelbert HR. Metabolic imaging to assess myocardial viability. J Nucl Med 1994;35(Suppl 4):8S-14S.
6. Schwaiger M, Beanlands R, vom Dahl J. Metabolic tissue characterization in the failing heart by positron emission tomography. Eur Heart J 1994;15(Suppl D):14-9.
7. Wolpers HG, Burchert W, van den Hoff J, Weinhardt R, Meyer GJ, Lichtlen PR. Positron emission tomography. Threshold criteria of reversible dysfunction. Circulation 1997;18(95):1417-24.
8. Nakata T, Hashimoto A, Kobayashi H, Miyamoto K, Tsuchihashi K, Miura T, et al. Outcome significance of thallium-201 and iodine-123-BMIPP perfusion-metabolism mismatch in preinfarction angina. J Nucl Med 1998;39:1492-9.
9. (18)F-FDG PET imaging in patients with non-insulin-dependent diabetes mellitus, coronary artery disease, and left ventricular dysfunction. J Nucl Med 2001;42:1730-6.
10. 18F-deoxyglucose and the assessment of myocardial viability. Semin Nucl Med 2002;32:60-9.
11. Knapp FF Jr, Franken P, Kropp J. Cardiac SPECT with iodine-123-labeled fatty acids: evaluation of myocardial viability with BMIPP. J Nucl Med 1995;36:1022-30.
12. Nohara R, Okuda K, Ogino M, Hosokawa R, Tamaki N, Konishi J, et al. Evaluation of myocardial viability with iodine-123-BMIPP in a canine model. J Nucl Med 1996;37: 1403-7.
13. vom Dahl J, Altehoefer C, Sheehan FH, Buechin P, Schulz G, Schwarz ER, et al. Effect of myocardial viability assessed by technetium-99m-sestamibi SPECT and fluorine-18-FDG PET on clinical outcome in coronary artery disease. J Nucl Med 1997; 38:742-8.
14. Kofoed KF, Hansen PR, Holm S, Hove JD, Chen K, Jin W, et al. Regional myocardial oxygen consumption estimated by carbon-11 acetate and positron emission tomography before and after repetitive ischemia. J Nucl Cardiol 2000;7:228-34.
15. 11C-acetate. J Nucl Med 2001;42:63-70.
16. Lui Z, Johnson G, Beju D, Okada RD. Detection of myocardial viability in ischemic-reperfused rat hearts by Tc-99m sestamibi kinetics. J Nucl Cardiol 2001;8:677-86.
17. 18F] 2-deoxy-2-fluoro-D-glucose for assessing myocardial glucose uptake. Circulation 1995;91:2435-44.
18. Botker HA, Goodwin GA, Holden JE, Doenst T, Gjedde A, Taegtmeyer H. Myocardial glucose uptake measured with fluorodeoxyglucose: a proposed method to account for variable lumped constants. J Nucl Med 1999;40:1186-96.
19. 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts. Biophys J 1995;69:2090-103.
20. Yu X, White LT, Alpert NM, Lewandowski ED. Subcellular metabolite transport and carbon isotope kinetics in the intramyocardial glutamate pool. Biochemistry 1996;35:6963-8.
21. Griffin J, O'Donnell JM, White LT, Hajjar RJ, Lewandowski ED. Postnatal expression and activity of the 2-oxoglutarate malate carrier in intact hearts. Am J Physiol Cell Physiol 2000; 279:C1704-9.
22. O'Donnell JM, Alpert NM, White LT, Lewandowski ED. Coupling of mitochondrial fatty acid uptake to oxidative flux in the intact heart. Biophys J 2002;82:11-8.
23. Wamblot RB, Henning SL, English DR, Dyachkova Y, Lopaschuk GD, Allard MF. Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia. J Mol Cell Cardiol 1999;31:493-502.
24. Weiss RG, Kalil-Filho R, Herskowitz A, Chacko VP, Litt M. Tricarboxylic acid cycle activity in postischemic rat hearts. Circulation 1993;87:270-82.
25. 13C NMR analysis of oxidative metabolism in the in vivo canine myocardium. J Biol Chem 1993;268:26296-301.
26. Lewandowski ED, Yu X, White LT, Doumen C, LaNoue KF, O'Donnell JM. Altered metabolite exchange between subcellular compartments in intact postischemic hearts. Circ Res 1997;81: 165-74.
27. O'Donnell JM, Doumen C, LaNoue KF, White LT, Yu X, Alpert NM, et al. Dehydrogenase regulation of metabolite oxidation and efflux from mitochondria of intact hearts. Am J Physiol Heart Circ Physiol 1998;274:H467-76.
28. O'Donnell JM, White LT, Lewandowski ED. Mitochondrial transporter responsiveness and metabolic flux homeostasis in postischemic hearts. Am J Physiol Heart Circ Physiol 1999;277: H866-73.
29. (13)C NMR resonance of glutamate for measuring oxygen consumption in tissue. Am J Physiol 1999;277(6 Pt 1):E1111-21.
30. (1)H. Am J Physiol Heart Circ Physiol 2001;281:H1413-21.
31. 13C NMR. Proc Natl Acad Sci U S A 1999;96:8235-40.
32. 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla. Dev Neurosci 1998;20:380-8.
33. (13)C] MRS and fMRI. Magn Reson Med 2001;45:349-55.
34. Bottomly PA, Hardy CJ, Roemer PB, Mueller OM. Proton-decoupled, Overhauser-enhanced, spatially localized carbon-13 spectroscopy in humans. Magn Reson Med 1989;12: 348-63.
35. 13C NMR studies in perfused rat hearts. J Biol Chem 1983;258:13785-94.
36. 13C NMR spectroscopy. FEBS Lett 1987;212:58-62.
37. Jeffrey FM, Diczku V, Sherry AD, Malloy CR. Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration. Basic Res Cardiol 1995;90:388-96.
38. Collins-Nakai RL, Noseworthy D, Lopaschuk GD. Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism. Am J Physiol 1994;267(5 Pt 2):H1862-71.
39. Lewandowski ED, Kudej RK, White LT, O'Donnell JM, Vatner SF. Mitochondrial preference for short chain fatty acid oxidation during coronary artery constriction. Circulation 2002;105:367-72.
40. 13C NMR spectra of intact hearts under conditions of varied metabolite enrichment. Magn Reson Med 1991;19:186-90.
41. Lewandowski ED, Chari MV, Roberts R, Johnston DL. NMR studies of beta-oxidation and short chain fatty acid metabolism during recovery of reperfused hearts. Am J Physiol Heart Circ Physiol 1991;261:H354-63.
42. 13C-labeled metabolites in the in vivo canine heart by B1 insensitive heteronuclear coherent polarization transfer and comparison of signal enhancement with NOE. Magn Reson Med 1997;37:327-30.
43. 13C NMR spectra of hearts: theoretical analysis and practical considerations. Am J Physiol Cell Physiol 1997;272:C2037-48.
44. 13C NMR. FEBS Lett 1981;26(123):315-8.
45. 13C NMR. J Biol Chem 1985;260:9272-79.
46. 31P NMR analyses. Am J Physiol Heart Circ Physiol 1990;258:H1357-65.
47. 31P NMR assessment of altered metabolism during grade reductions in coronary flow in intact rat hearts. Proc Natl Acad Sci U S A 1989;86:6426-30.
48. Johnston DL, Lewandowski ED. Fatty acid metabolism and contractile function in the reperfused myocardium: multinuclear NMR studies of isolated rabbit hearts. Circ Res 1991;68:714-25.
49. Lewandowski ED. NMR evaluation of metabolic and respiratory support of workload in intact rabbit hearts. Circ Res 1992;70: 576-82.
50. 13C NMR signal from glutamate and direct detection of TCA cycle intermediates. Magn Reson Med 1996;35:149-54.
51. Laughlin MR, Taylor J, Chesnick AS, DeGroot M, Balaban RS. Pyruvate and lactate metabolism in the in vivo dog heart. Am J Physiol 1993;264(6 Pt 2):H2068-79.
52. Kalil-Filho R, Gerstenblith G, Hansford RG, Chacko VP, Vandegaer K, Weiss RG. Regulation of myocardial glycogenolysis during post-ischemic reperfusion. J Mol Cell Cardiol 1991;23:1467-79.
53. Weiss RG, de Albuquirque CP, Vandegaer K, Chacko VP, Gerstenblath G. Attenuated glycogenolysis reduced catabolite accumulation during ischemia in preconditioned rat hearts. Circ Res 1996;79:435-46.
54. Damico LA, White LT, Yu X, Lewandowski ED. Chemical versus isotopic equilibrium and the metabolic fate of glycolytic end products in the heart. J Mol Cell Cardiol 1996;28: 989-99.
55. McNulty PH, Jagasia D, Cline CW, Ng CK, Whiting JM, Garg P, et al. Persistent changes in myocardial glucose metabolism in vivo during reperfusion of a limited-duration coronary occlusion. Circulation 2000;101:917-22.
56. (13)C] glucose metabolism in conscious rats. Am J Physiol Heart Circ Physiol 2000;279:H375-81.
57. Lewandowski ED, White LT. Pyruvate dehydrogenase influences postischemic heart function. Circulation 1995;91:2071-9.
58. 13C NRM analysis of pyruvate and lactate oxidation in the in vivo canine myocardium: evidence of reduced utilization with increased work. Magn Reson Med 1997;38:896-906.
59. Lewandowski ED, Damico LA, White LT, Yu X. Cardiac responses to induced lactate oxidation: NMR analysis of metabolic equilibria. Am J Physiol Heart Circ Physiol 1995;269: H160-8.
60. White LT, O'Donnell JM, Griffin J, Lewandowski ED. Cytosolic redox state mediates postischemic response to pyruvate dehydrogenase stimulation. Am J Physiol Heart Circ Physiol 1999;277:H626-34.
61. Griffin J, White LT, Lewandowski ED. Proton production determines substrate dependent recovery of stunned hearts during pyruvate dehydrogenase stimulation. Am J Physiol Heart Circ Physiol 2000;279:H361-7.
62. Seymour AM, Chatham JC. The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity. J Mol Cell Cardiol 1997-29-2771-8.
63. Chatham JC, Forder JR. Relationship between cardiac function and substrate oxidation in hearts of diabetic rats. Am J Physiol 1997;273(l Pt 2):H52-8.