Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications

ACS Chemical Biology

Volumn 2, Issue 11, 2007, Pages 711-714

  Aymes, Tina L ^a   Richard, John P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE; 5' METHYLTHIOADENOSINE NUCLEOSIDASE INHIBITOR; 5' METHYLTHIOADENOSINE PHOSPHORYLASE; AGENTS AFFECTING METABOLISM; DADME IMMUCILLIN H; ENZYME INHIBITOR; FORODESINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CATALYSIS; CLINICAL TRIAL; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME MECHANISM; ESCHERICHIA COLI; HELICOBACTER PYLORI; HUMAN; HYDROLYSIS; KLEBSIELLA PNEUMONIAE; LYMPHOCYTE PROLIFERATION; MICHAEL ADDITION; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; SOLVOLYSIS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; T CELL LEUKEMIA;

BACTERIAL PROTEINS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR CONFORMATION; N-GLYCOSYL HYDROLASES; PURINE-NUCLEOSIDE PHOSPHORYLASE;

EID: 37349042159     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700228t     Document Type: Article

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