Thermodynamics of A2B adenosine receptor binding discriminates agonistic from antagonistic behaviour

Biochemical Pharmacology

Volumn 75, Issue 2, 2008, Pages 562-569

  Gessi, Stefania ^a   Fogli, Eleonora ^a   Sacchetto, Valeria ^a   Varani, Katia ^a   Merighi, Stefania ^a   Leung, Edward ^b   Lennan, Stephen Mac ^b   Borea, Pier Andrea ^a  

^a Interdisciplinary Center for the Study of Inflammation   (Italy)

^b King Pharmaceuticals   (United States)

Author keywords

Adenosine A2B receptor; Agonist antagonist discrimination; Binding mechanisms; Binding thermodynamics; Drug development; Enthalpy entropy compensation

Indexed keywords

1 DEOXY 1 [6 [4 [(4 TERT BUTYL PHENYLCARBAMOYL) METHOXYL PHENYLAMINO] 9H PURIN 9 YL] N ETHYL BETA DEXTRO RIBOFURANURONAMIDE; 1 DEOXY 1 [6 [4 [(PHENYLCARBAMOYL) METHOXY]PHENYLAMINO] 9H PURIN 9 YL] N ETHYL BETA DEXTRO RIBOFURANURONAMIDE; 2 (4 BENZYLOXY PHENYL) N [5(2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YL] ACETAMIDE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; N [5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YL] 2 PHENYL ACETAMIDE; N BENZO[1,3]DIOXOL 5 YL 2 [5 (1,3 DIPROPYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YL OXY] ACETAMIDE; UNCLASSIFIED DRUG; LIGAND;

AGONIST; ARTICLE; BINDING AFFINITY; DRUG ANTAGONISM; EMBRYO; ENTHALPY; ENTROPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; RECEPTOR BINDING; TEMPERATURE; THERMODYNAMICS; CELL LINE; DRUG POTENTIATION; METABOLISM;

CELL LINE; ENTROPY; HUMANS; LIGANDS; RECEPTOR, ADENOSINE A2B; THERMODYNAMICS;

EID: 37349029453     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.09.003     Document Type: Article

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