N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 7, 2007, Pages 2514-2527

  Baraldi, Pier Giovanni ^a   Preti, Delia ^a   Tabrizi, Mojgan Aghazadeh ^a   Fruttarolo, Francesca ^a   Saponaro, Giulia ^a   Baraldi, Stefania ^a   Romagnoli, Romeo ^a   Moorman, Allan R ^b   Gessi, Stefania ^a   Varani, Katia ^a   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b King Pharmaceuticals   (United States)

Author keywords

A2B receptors; Adenosine; Agonists; N6 substituted NECA

Indexed keywords

1 DEOXY 1 [6 [4 [(PHENYLCARBAMOYL)METHOXY]PHENYLAMINO] 9H PURIN 9 YL] N ETHYL BETA DEXTRO RIBOFURANURONAMIDE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2B RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE; ANIMALS; CARBAMATES; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; INDICATORS AND REAGENTS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2B;

EID: 33847664739     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.055     Document Type: Article

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