Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors

Biochemical Pharmacology

Volumn 56, Issue 11, 1998, Pages 1437-1445

  Dalpiaz, Alessandro ^a   Townsend Nicholson, Andrea ^b   Beukers, Margot W ^a   Schofield, Peter R ^c   Ijzerman, Adriaan P ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Binding thermodynamics; Cloned human adenosine A1 receptor; Full and partial agonist; High affinity and low affinity receptor states; Mutant human adenosine A1 receptor

Indexed keywords

6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR; ALANINE; BRAIN RECEPTOR; PARTIAL AGONIST; THREONINE;

AGONIST; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BRAIN MEMBRANE; CHO CELL; CONTROLLED STUDY; ENTHALPY; ENTROPY; HUMAN; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; TEMPERATURE; THERMODYNAMICS;

ADENOSINE; ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; ENTROPY; HUMANS; KINETICS; POINT MUTATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, PURINERGIC P1; THEOPHYLLINE; THERMODYNAMICS; THREONINE; TRANSFECTION; XANTHINES;

EID: 0031737666     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00202-0     Document Type: Article

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