메뉴 건너뛰기




Volumn 45, Issue 11, 2007, Pages 672-682

Brain regulation of food intake and expenditure energy: Molecular action of insulin, leptin and physical exercise;Regulación central de la ingestión alimentaria y el gasto energético: Acciones moleculares de la insulina, la leptina y el ejercicio físico

Author keywords

Hypothalamus; Insulin; Interleukin 6; Leptin; Obesity; Physical exercise

Indexed keywords

INSULIN; INTERLEUKIN 6; LEPTIN;

EID: 37349015935     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.4511.2006612     Document Type: Review
Times cited : (17)

References (93)
  • 1
    • 0036712032 scopus 로고    scopus 로고
    • Exercise and gene expression: Physiological regulation of the human genome through activity
    • Booth FW, Chakravarthy MV, Spangenburg EE. Exercise and gene expression: physiological regulation of the human genome through activity. J Physiol 2002; 543: 399-411.
    • (2002) J Physiol , vol.543 , pp. 399-411
    • Booth, F.W.1    Chakravarthy, M.V.2    Spangenburg, E.E.3
  • 3
    • 0842324779 scopus 로고    scopus 로고
    • Obesity wars: Molecular progress confronts an expanding epidemic
    • Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004; 116: 337-50.
    • (2004) Cell , vol.116 , pp. 337-350
    • Flier, J.S.1
  • 4
    • 0002244634 scopus 로고
    • The physiology of motivation
    • Stellar E. The physiology of motivation. Physiol Rev 1994; 101: 301-11.
    • (1994) Physiol Rev , vol.101 , pp. 301-311
    • Stellar, E.1
  • 5
    • 25444482392 scopus 로고    scopus 로고
    • Brain regulation of food intake and appetite: Molecules and networks
    • Broberger C. Brain regulation of food intake and appetite: molecules and networks. J Intern Med 2005; 258: 301-27.
    • (2005) J Intern Med , vol.258 , pp. 301-327
    • Broberger, C.1
  • 7
    • 0017276160 scopus 로고
    • Entry peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood
    • Broadwell RD, Brightman MW. Entry peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 1976; 166: 257-83.
    • (1976) J Comp Neurol , vol.166 , pp. 257-283
    • Broadwell, R.D.1    Brightman, M.W.2
  • 8
    • 4544306391 scopus 로고    scopus 로고
    • Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
    • Niswender KD, Baskin DG, Schwartz MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab 2004; 15: 362-8.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 362-368
    • Niswender, K.D.1    Baskin, D.G.2    Schwartz, M.W.3
  • 9
    • 0033436355 scopus 로고    scopus 로고
    • Insulin and leptin: Dual adiposity signals to the brain for the regulation of food intake and body weight
    • Baskin DG, Lattemann DF, Seeley RJ, Woods SC, Porte D Jr, Schwartz MW. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res 1999; 848: 114-23.
    • (1999) Brain Res , vol.848 , pp. 114-123
    • Baskin, D.G.1    Lattemann, D.F.2    Seeley, R.J.3    Woods, S.C.4    Porte Jr, D.5    Schwartz, M.W.6
  • 10
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-70.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 13
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093-6.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 14
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due mutations in the OB (leptin) receptor
    • Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, et al. Phenotypes of mouse diabetes and rat fatty due mutations in the OB (leptin) receptor. Science 1996; 271: 994-6.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua Jr, S.C.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.M.5    Tartaglia, L.6
  • 17
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signaling pathways activated by leptin
    • Fruhbeck G. Intracellular signaling pathways activated by leptin. Biochem J 2006; 393 (Pt 1): 7-20.
    • (2006) Biochem J , vol.393 , Issue.PART 1 , pp. 7-20
    • Fruhbeck, G.1
  • 18
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C, Uotani S, Da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686-95.
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 19
    • 2342439732 scopus 로고    scopus 로고
    • Leptin signaling in the central nervous system and the periphery
    • Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Rec Prog Horm Res 2004; 59: 305-31.
    • (2004) Rec Prog Horm Res , vol.59 , pp. 305-331
    • Bjorbaek, C.1    Kahn, B.B.2
  • 20
    • 0036168190 scopus 로고    scopus 로고
    • Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
    • Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, et al. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity Endocrinology 2002; 143: 775-83.
    • (2002) Endocrinology , vol.143 , pp. 775-783
    • Hileman, S.M.1    Pierroz, D.D.2    Masuzaki, H.3    Bjorbaek, C.4    El-Haschimi, K.5    Banks, W.A.6
  • 21
    • 0031577546 scopus 로고    scopus 로고
    • Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and e in different mouse tissues
    • Löllmann B, Gruninger S, Stricker-Krongrad A, Chiesi M. Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and e in different mouse tissues. Biochem Biophys Res Commun 1997; 238: 648-52.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 648-652
    • Löllmann, B.1    Gruninger, S.2    Stricker-Krongrad, A.3    Chiesi, M.4
  • 23
    • 0036307849 scopus 로고    scopus 로고
    • Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: Observational and interventional studies in humans
    • Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 2002; 51: 2105-12.
    • (2002) Diabetes , vol.51 , pp. 2105-2112
    • Chan, J.L.1    Bluher, S.2    Yiannakouris, N.3    Suchard, M.A.4    Kratzsch, J.5    Mantzoros, C.S.6
  • 25
    • 17844401180 scopus 로고    scopus 로고
    • Molecular and anatomical determinants of central leptin resistance
    • Munzberg H, Myers MG. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005; 8: 566-70.
    • (2005) Nat Neurosci , vol.8 , pp. 566-570
    • Munzberg, H.1    Myers, M.G.2
  • 26
    • 0030828823 scopus 로고    scopus 로고
    • Leptin activates PI3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
    • Kelerrer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 1997; 40: 1358-62.
    • (1997) Diabetologia , vol.40 , pp. 1358-1362
    • Kelerrer, M.1    Koch, M.2    Metzinger, E.3    Mushack, J.4    Capp, E.5    Haring, H.U.6
  • 30
    • 0037228018 scopus 로고    scopus 로고
    • Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI3-kinase-mediated signaling in rat liver
    • Carvalheira JB, Ribeiro EB, Folli F, Velloso LA, Saad MJ. Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI3-kinase-mediated signaling in rat liver. Biol Chem 2003; 384: 151-9.
    • (2003) Biol Chem , vol.384 , pp. 151-159
    • Carvalheira, J.B.1    Ribeiro, E.B.2    Folli, F.3    Velloso, L.A.4    Saad, M.J.5
  • 32
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000; 106: 473-81.
    • (2000) J Clin Invest , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 33
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • Woods SC, Lotter EC, McKay LD, Porte D Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979; 282: 503-5.
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte Jr., D.4
  • 34
    • 0020065416 scopus 로고
    • Insulin stimulates the phosphorilation of the 95,000-dalton subunit of its own receptor
    • Kasuga M, Karisson FA, Kahn CR. Insulin stimulates the phosphorilation of the 95,000-dalton subunit of its own receptor. Science 1982; 215: 185-7.
    • (1982) Science , vol.215 , pp. 185-187
    • Kasuga, M.1    Karisson, F.A.2    Kahn, C.R.3
  • 35
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 36
    • 0030748457 scopus 로고    scopus 로고
    • The insulin signaling system and the IRS proteins
    • White MF. The insulin signaling system and the IRS proteins. Diabetologia 1997; 40: S2-17.
    • (1997) Diabetologia , vol.40
    • White, M.F.1
  • 40
    • 0029786390 scopus 로고    scopus 로고
    • Insulin reduces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat
    • Saad MJ, Carvalho CR, Thirone AC, Velloso LA. Insulin reduces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. J Biol Chem 1996; 271: 22100-4.
    • (1996) J Biol Chem , vol.271 , pp. 22100-22104
    • Saad, M.J.1    Carvalho, C.R.2    Thirone, A.C.3    Velloso, L.A.4
  • 42
    • 33745576798 scopus 로고    scopus 로고
    • Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
    • Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, et al. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci 2006; 9: 1-6.
    • (2006) Nat Neurosci , vol.9 , pp. 1-6
    • Kim, M.S.1    Pak, Y.K.2    Jang, P.G.3    Namkoong, C.4    Choi, Y.S.5    Won, J.C.6
  • 43
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003; 423: 550-5.
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3    Walkey, C.J.4    Yoon, J.C.5    Oriente, F.6
  • 44
    • 0036950665 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    • Kitamura T. Nakae J, Kitamura Y, Kido Y, Biggs WH III, Wright CV, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002; 110: 1839-47.
    • (2002) J Clin Invest , vol.110 , pp. 1839-1847
    • Kitamura, T.1    Nakae, J.2    Kitamura, Y.3    Kido, Y.4    Biggs III, W.H.5    Wright, C.V.6
  • 45
    • 0028029856 scopus 로고
    • Insulin receptor substrate-1 (IRS1) distribution in the rat central nervous system
    • Folli F, Bonfanti L, Renard E, Kahn CR, Merighi A. Insulin receptor substrate-1 (IRS1) distribution in the rat central nervous system. J Neurosci 1994; 14: 6412-22.
    • (1994) J Neurosci , vol.14 , pp. 6412-6422
    • Folli, F.1    Bonfanti, L.2    Renard, E.3    Kahn, C.R.4    Merighi, A.5
  • 46
    • 0033599752 scopus 로고    scopus 로고
    • Insulin induces tyrosine phosphorylation of the insulin receptor and SHC, and SHC/GRB2 association in cerebellum but not in forebrain cortex of rats
    • De L.A. Fernandes ML, Saad MJ, Velloso LA. Insulin induces tyrosine phosphorylation of the insulin receptor and SHC, and SHC/GRB2 association in cerebellum but not in forebrain cortex of rats. Brain Res 1999; 826: 74-82.
    • (1999) Brain Res , vol.826 , pp. 74-82
    • De, L.A.1    Fernandes, M.L.2    Saad, M.J.3    Velloso, L.A.4
  • 47
    • 0242552065 scopus 로고    scopus 로고
    • Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats
    • Pereira-Da Silva M, Torsoni MA, Nourani HV, Augusto VD, Souza CT, Gasparetti AL, et al. Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology 2003; 144: 4831-40.
    • (2003) Endocrinology , vol.144 , pp. 4831-4840
    • Pereira-Da Silva, M.1    Torsoni, M.A.2    Nourani, H.V.3    Augusto, V.D.4    Souza, C.T.5    Gasparetti, A.L.6
  • 48
    • 0033458104 scopus 로고    scopus 로고
    • Effects of dexamethasone on the body weight set point of rats
    • Michel C, Cabanac M. Effects of dexamethasone on the body weight set point of rats. Physiol Behav 1999, 68: 145-50.
    • (1999) Physiol Behav , vol.68 , pp. 145-150
    • Michel, C.1    Cabanac, M.2
  • 50
    • 0026795166 scopus 로고
    • Glucocorticoids are required for food-deprivation-induced increases in hypothalamic neuropeptide Y expression
    • Ponsalle P, Srivistava LS, Uht RM, White JD. Glucocorticoids are required for food-deprivation-induced increases in hypothalamic neuropeptide Y expression. Neuroendocrinology 1993, 4: 585-91.
    • (1993) Neuroendocrinology , vol.4 , pp. 585-591
    • Ponsalle, P.1    Srivistava, L.S.2    Uht, R.M.3    White, J.D.4
  • 51
    • 0031039669 scopus 로고    scopus 로고
    • Elevated corticosterone is not required for the rapid induction of neuropeptide Y gene expression by an overnight fast
    • Hanson ES, Levin N, Dallman MF. Elevated corticosterone is not required for the rapid induction of neuropeptide Y gene expression by an overnight fast. Endocrinology 1997; 138: 1041-7.
    • (1997) Endocrinology , vol.138 , pp. 1041-1047
    • Hanson, E.S.1    Levin, N.2    Dallman, M.F.3
  • 52
  • 53
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • Araki E, Lipes MA, Patti ME, Bruning JC, Haag B, Johnson RS. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994; 372: 186-90.
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3    Bruning, J.C.4    Haag, B.5    Johnson, R.S.6
  • 55
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-70.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 57
    • 0035654860 scopus 로고    scopus 로고
    • Leptin and the control of obesity
    • Wilding JP. Leptin and the control of obesity. Curr Opin Pharmacol 2001; 6: 656-61.
    • (2001) Curr Opin Pharmacol , vol.6 , pp. 656-661
    • Wilding, J.P.1
  • 60
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe earlyonset obesity in humans
    • Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H Wareham NJ, et al. Congenital leptin deficiency is associated with severe earlyonset obesity in humans. Nature 1997; 387: 903-8.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3    Soos, M.A.4    Rau, H.5    Wareham, N.J.6
  • 61
    • 23844535138 scopus 로고    scopus 로고
    • Physical activity considerations for the treatment and prevention of obesity
    • Jakicic JM, Otto AM. Physical activity considerations for the treatment and prevention of obesity. Am J Clin Nutr 2005; 82: S226-9.
    • (2005) Am J Clin Nutr , vol.82
    • Jakicic, J.M.1    Otto, A.M.2
  • 62
    • 12844274354 scopus 로고    scopus 로고
    • Modulatory role of food, feeding regime and physical exercise on body weight and insulin resistance
    • Kretschmer BD, Schelling P, Norbert B, Liebscher C, Treutel S, Kruger N, et al. Modulatory role of food, feeding regime and physical exercise on body weight and insulin resistance. Life Sci 2005; 76: 1553-73.
    • (2005) Life Sci , vol.76 , pp. 1553-1573
    • Kretschmer, B.D.1    Schelling, P.2    Norbert, B.3    Liebscher, C.4    Treutel, S.5    Kruger, N.6
  • 63
    • 0036265048 scopus 로고    scopus 로고
    • The ability of habitual exercise to influence appetite and food intake in response to high- and low-energy preloads in man
    • Long SJ, Hart K, Morgan M. The ability of habitual exercise to influence appetite and food intake in response to high- and low-energy preloads in man. Br J Nutr 2002; 87: 517-23.
    • (2002) Br J Nutr , vol.87 , pp. 517-523
    • Long, S.J.1    Hart, K.2    Morgan, M.3
  • 66
    • 0036317019 scopus 로고    scopus 로고
    • Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway
    • Luciano E, Carneiro EM, Carvalho CR, Carvalheira JB, Peres SB, Reis MA, et al. Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol 2002; 147: 149-57.
    • (2002) Eur J Endocrinol , vol.147 , pp. 149-157
    • Luciano, E.1    Carneiro, E.M.2    Carvalho, C.R.3    Carvalheira, J.B.4    Peres, S.B.5    Reis, M.A.6
  • 67
    • 0032954067 scopus 로고    scopus 로고
    • Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes
    • Kennedy JW, Hirshman MF, Gervino EV, Ocel JV, Forse RA, Hoenig SJ, et al. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes 1999; 48: 1192-7.
    • (1999) Diabetes , vol.48 , pp. 1192-1197
    • Kennedy, J.W.1    Hirshman, M.F.2    Gervino, E.V.3    Ocel, J.V.4    Forse, R.A.5    Hoenig, S.J.6
  • 69
    • 0031978984 scopus 로고    scopus 로고
    • Exercise, glucose transport, and insulin sensitivity
    • Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 1998; 49: 235-61.
    • (1998) Annu Rev Med , vol.49 , pp. 235-261
    • Goodyear, L.J.1    Kahn, B.B.2
  • 70
    • 0036021855 scopus 로고    scopus 로고
    • Invited review: Effects of acute exercise and exercise training on insulin resistance
    • Henriksen EJ. Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002; 93: 788-96.
    • (2002) J Appl Physiol , vol.93 , pp. 788-796
    • Henriksen, E.J.1
  • 72
    • 0032697037 scopus 로고    scopus 로고
    • Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice
    • Wojtaszewski JF, Higaki Y, Hirshman MF, Michael MD, Dufresne SD, Kahn CR, et al. Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. J Clin Invest 1999; 104: 1257-64.
    • (1999) J Clin Invest , vol.104 , pp. 1257-1264
    • Wojtaszewski, J.F.1    Higaki, Y.2    Hirshman, M.F.3    Michael, M.D.4    Dufresne, S.D.5    Kahn, C.R.6
  • 73
    • 0030853559 scopus 로고    scopus 로고
    • Meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention
    • Miller WC, Koceja DM, Hamilton EJA. Meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention. Int J Obes Relat Metab Disord 1997; 21: 941-7.
    • (1997) Int J Obes Relat Metab Disord , vol.21 , pp. 941-947
    • Miller, W.C.1    Koceja, D.M.2    Hamilton, E.J.A.3
  • 74
    • 33645732140 scopus 로고
    • Physical activity and long-term maintenance of weight loss
    • Pronk NP, Wing RR, Hamilton EJ. Physical activity and long-term maintenance of weight loss. Obes Res 1994; 2: 587-91.
    • (1994) Obes Res , vol.2 , pp. 587-591
    • Pronk, N.P.1    Wing, R.R.2    Hamilton, E.J.3
  • 75
    • 0028818087 scopus 로고
    • Lesion of central nucleus of amygdala promotes fat gain without preventing effect of exercise on energy balance
    • Bovetto S, Richard D. Lesion of central nucleus of amygdala promotes fat gain without preventing effect of exercise on energy balance. Am J Physiol 1995; 269: R781-6.
    • (1995) Am J Physiol , vol.269
    • Bovetto, S.1    Richard, D.2
  • 76
    • 0025118414 scopus 로고
    • Involvement of corticotropin-releasing factor in the anorexia induced by exercise
    • Rivest S, Richard D. Involvement of corticotropin-releasing factor in the anorexia induced by exercise. Brain Res Bull 1990; 25: 169-72.
    • (1990) Brain Res Bull , vol.25 , pp. 169-172
    • Rivest, S.1    Richard, D.2
  • 77
    • 33745224150 scopus 로고    scopus 로고
    • Integration of feeding and spontaneous physical activity: Role for orexin
    • Kotz CM. Integration of feeding and spontaneous physical activity: role for orexin. Physiol Behav 2006; 88: 294-301.
    • (2006) Physiol Behav , vol.88 , pp. 294-301
    • Kotz, C.M.1
  • 78
    • 33749170808 scopus 로고    scopus 로고
    • Eje hipotálamo-pituitario: Efectos del entrenamiento físico en ratas Wistar con administración de dexametasona
    • Pauli JR, Gomes RJ, Luciano E. Eje hipotálamo-pituitario: efectos del entrenamiento físico en ratas Wistar con administración de dexametasona. Rev Neurol 2006; 42: 325-31.
    • (2006) Rev Neurol , vol.42 , pp. 325-331
    • Pauli, J.R.1    Gomes, R.J.2    Luciano, E.3
  • 79
    • 0031019661 scopus 로고    scopus 로고
    • Brain monoamines, exercise, and behavioral stress: Animal models
    • Dishman RK. Brain monoamines, exercise, and behavioral stress: animal models. Med Sci Sports Exerc 1997; 29: 63-74.
    • (1997) Med Sci Sports Exerc , vol.29 , pp. 63-74
    • Dishman, R.K.1
  • 80
    • 0010330438 scopus 로고    scopus 로고
    • Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
    • Neeper SA, Gómez-Pinilla F, Choi J, Cotman CW. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 1996; 726: 49-56.
    • (1996) Brain Res , vol.726 , pp. 49-56
    • Neeper, S.A.1    Gómez-Pinilla, F.2    Choi, J.3    Cotman, C.W.4
  • 81
    • 0021717476 scopus 로고
    • Chronic norepinephrine injection into the hypothalamic paraventricular nucleus produces hyperphagia and increased body weight in the rat
    • Leibowitz SF, Roossin P, Rosenn M. Chronic norepinephrine injection into the hypothalamic paraventricular nucleus produces hyperphagia and increased body weight in the rat. Pharmacol Biochem Behav 1984; 21: 801-8.
    • (1984) Pharmacol Biochem Behav , vol.21 , pp. 801-808
    • Leibowitz, S.F.1    Roossin, P.2    Rosenn, M.3
  • 82
    • 0019582884 scopus 로고
    • Increased food intake, body weight, and adiposity in rats after regional neurochemical depletion of serotonin
    • Waldbillig RJ, Bartness TJ, Stanley BG. Increased food intake, body weight, and adiposity in rats after regional neurochemical depletion of serotonin. J Comp Physiol Psychol 1981; 95: 391-405.
    • (1981) J Comp Physiol Psychol , vol.95 , pp. 391-405
    • Waldbillig, R.J.1    Bartness, T.J.2    Stanley, B.G.3
  • 83
    • 0033592920 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    • Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A 1999; 96: 15239-44.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 15239-15244
    • Lyons, W.E.1    Mamounas, L.A.2    Ricaurte, G.A.3    Coppola, V.4    Reid, S.W.5    Bora, S.H.6
  • 84
    • 15444363197 scopus 로고    scopus 로고
    • Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima fatty rats: Role of hypothalamic signaling
    • Bi S, Scott KA, Hyun J, Ladenheim EE, Moran TH. Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima fatty rats: role of hypothalamic signaling. Endocrinology 2005; 146: 1676-85.
    • (2005) Endocrinology , vol.146 , pp. 1676-1685
    • Bi, S.1    Scott, K.A.2    Hyun, J.3    Ladenheim, E.E.4    Moran, T.H.5
  • 85
    • 0038306201 scopus 로고    scopus 로고
    • Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats
    • Shin MS, Kim H, Chang HK, Lee TH, Jang MH, Shin MC, et al. Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats. Neurosci Lett 2003; 346: 157-60.
    • (2003) Neurosci Lett , vol.346 , pp. 157-160
    • Shin, M.S.1    Kim, H.2    Chang, H.K.3    Lee, T.H.4    Jang, M.H.5    Shin, M.C.6
  • 89
    • 34147159710 scopus 로고    scopus 로고
    • Febbraio MA. gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest 2007; 117: 841-9.
    • Febbraio MA. gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest 2007; 117: 841-9.
  • 90
    • 33746075210 scopus 로고    scopus 로고
    • gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
    • Janoschek R, Plum L, Koch L, Munzberg H, Diano S, Bruning JC. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proc Natl Acad Sci U S A 2006; 103: 10707-12.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10707-10712
    • Janoschek, R.1    Plum, L.2    Koch, L.3    Munzberg, H.4    Diano, S.5    Bruning, J.C.6
  • 91
    • 0346157324 scopus 로고    scopus 로고
    • Acquiring signaling specificity from the receptor gp130
    • Ernst M, Jenkins BJ. Acquiring signaling specificity from the receptor gp130. Trends Genet 2004; 20: 23-32.
    • (2004) Trends Genet , vol.20 , pp. 23-32
    • Ernst, M.1    Jenkins, B.J.2
  • 92
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-8.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 93
    • 0028279791 scopus 로고
    • Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    • Boulton TG, Stahl N, Yancopoulos GD. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 1994; 269: 11648-55.
    • (1994) J Biol Chem , vol.269 , pp. 11648-11655
    • Boulton, T.G.1    Stahl, N.2    Yancopoulos, G.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.