-
1
-
-
0036712032
-
Exercise and gene expression: Physiological regulation of the human genome through activity
-
Booth FW, Chakravarthy MV, Spangenburg EE. Exercise and gene expression: physiological regulation of the human genome through activity. J Physiol 2002; 543: 399-411.
-
(2002)
J Physiol
, vol.543
, pp. 399-411
-
-
Booth, F.W.1
Chakravarthy, M.V.2
Spangenburg, E.E.3
-
2
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404: 661-71.
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr, D.3
Seeley, R.J.4
Baskin, D.G.5
-
3
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004; 116: 337-50.
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
4
-
-
0002244634
-
The physiology of motivation
-
Stellar E. The physiology of motivation. Physiol Rev 1994; 101: 301-11.
-
(1994)
Physiol Rev
, vol.101
, pp. 301-311
-
-
Stellar, E.1
-
5
-
-
25444482392
-
Brain regulation of food intake and appetite: Molecules and networks
-
Broberger C. Brain regulation of food intake and appetite: molecules and networks. J Intern Med 2005; 258: 301-27.
-
(2005)
J Intern Med
, vol.258
, pp. 301-327
-
-
Broberger, C.1
-
7
-
-
0017276160
-
Entry peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood
-
Broadwell RD, Brightman MW. Entry peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 1976; 166: 257-83.
-
(1976)
J Comp Neurol
, vol.166
, pp. 257-283
-
-
Broadwell, R.D.1
Brightman, M.W.2
-
8
-
-
4544306391
-
Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
-
Niswender KD, Baskin DG, Schwartz MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab 2004; 15: 362-8.
-
(2004)
Trends Endocrinol Metab
, vol.15
, pp. 362-368
-
-
Niswender, K.D.1
Baskin, D.G.2
Schwartz, M.W.3
-
9
-
-
0033436355
-
Insulin and leptin: Dual adiposity signals to the brain for the regulation of food intake and body weight
-
Baskin DG, Lattemann DF, Seeley RJ, Woods SC, Porte D Jr, Schwartz MW. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res 1999; 848: 114-23.
-
(1999)
Brain Res
, vol.848
, pp. 114-123
-
-
Baskin, D.G.1
Lattemann, D.F.2
Seeley, R.J.3
Woods, S.C.4
Porte Jr, D.5
Schwartz, M.W.6
-
10
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-70.
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
11
-
-
0042221558
-
Ultradian oscillations of leptin secretion in humans
-
Sinha MK, Sturis J, Ohannesian J, Magosin S, Stephens T, Heiman M, et al. Ultradian oscillations of leptin secretion in humans. Biochem Biophys Res Commun 1996; 228: 733-8.
-
(1996)
Biochem Biophys Res Commun
, vol.228
, pp. 733-738
-
-
Sinha, M.K.1
Sturis, J.2
Ohannesian, J.3
Magosin, S.4
Stephens, T.5
Heiman, M.6
-
12
-
-
0036027705
-
The leptin, a new hormone of adipose tissue: Clinical findings and perspectives in geriatrics
-
Maurigeri D, Bonanno MR, Speciale S, Santangelo A, Lentinia A, Russo MS, et al. The leptin, a new hormone of adipose tissue: clinical findings and perspectives in geriatrics. Arch Gerontol Geriatr 2002; 34: 47-54.
-
(2002)
Arch Gerontol Geriatr
, vol.34
, pp. 47-54
-
-
Maurigeri, D.1
Bonanno, M.R.2
Speciale, S.3
Santangelo, A.4
Lentinia, A.5
Russo, M.S.6
-
13
-
-
0030942844
-
The leptin receptor
-
Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093-6.
-
(1997)
J Biol Chem
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
14
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due mutations in the OB (leptin) receptor
-
Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, et al. Phenotypes of mouse diabetes and rat fatty due mutations in the OB (leptin) receptor. Science 1996; 271: 994-6.
-
(1996)
Science
, vol.271
, pp. 994-996
-
-
Chua Jr, S.C.1
Chung, W.K.2
Wu-Peng, X.S.3
Zhang, Y.4
Liu, S.M.5
Tartaglia, L.6
-
15
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-5.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
-
17
-
-
30044434035
-
Intracellular signaling pathways activated by leptin
-
Fruhbeck G. Intracellular signaling pathways activated by leptin. Biochem J 2006; 393 (Pt 1): 7-20.
-
(2006)
Biochem J
, vol.393
, Issue.PART 1
, pp. 7-20
-
-
Fruhbeck, G.1
-
18
-
-
0031436148
-
Divergent signaling capacities of the long and short isoforms of the leptin receptor
-
Bjorbaek C, Uotani S, Da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686-95.
-
(1997)
J Biol Chem
, vol.272
, pp. 32686-32695
-
-
Bjorbaek, C.1
Uotani, S.2
Da Silva, B.3
Flier, J.S.4
-
19
-
-
2342439732
-
Leptin signaling in the central nervous system and the periphery
-
Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Rec Prog Horm Res 2004; 59: 305-31.
-
(2004)
Rec Prog Horm Res
, vol.59
, pp. 305-331
-
-
Bjorbaek, C.1
Kahn, B.B.2
-
20
-
-
0036168190
-
Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
-
Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, et al. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity Endocrinology 2002; 143: 775-83.
-
(2002)
Endocrinology
, vol.143
, pp. 775-783
-
-
Hileman, S.M.1
Pierroz, D.D.2
Masuzaki, H.3
Bjorbaek, C.4
El-Haschimi, K.5
Banks, W.A.6
-
21
-
-
0031577546
-
Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and e in different mouse tissues
-
Löllmann B, Gruninger S, Stricker-Krongrad A, Chiesi M. Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and e in different mouse tissues. Biochem Biophys Res Commun 1997; 238: 648-52.
-
(1997)
Biochem Biophys Res Commun
, vol.238
, pp. 648-652
-
-
Löllmann, B.1
Gruninger, S.2
Stricker-Krongrad, A.3
Chiesi, M.4
-
22
-
-
0034805384
-
Soluble leptin receptor represents the main leptin binding activity in human blood
-
Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 2001; 283: 982-8.
-
(2001)
Biochem Biophys Res Commun
, vol.283
, pp. 982-988
-
-
Lammert, A.1
Kiess, W.2
Bottner, A.3
Glasow, A.4
Kratzsch, J.5
-
23
-
-
0036307849
-
Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: Observational and interventional studies in humans
-
Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 2002; 51: 2105-12.
-
(2002)
Diabetes
, vol.51
, pp. 2105-2112
-
-
Chan, J.L.1
Bluher, S.2
Yiannakouris, N.3
Suchard, M.A.4
Kratzsch, J.5
Mantzoros, C.S.6
-
24
-
-
0037862102
-
The ins and outs of leptin receptor activation
-
Zabeau L, Lavens D, Peelman F, Eyckerman S, Vandekerckhove J, Tavernier J. The ins and outs of leptin receptor activation. FEBS Lett 2003; 546; 45-50.
-
(2003)
FEBS Lett
, vol.546
, pp. 45-50
-
-
Zabeau, L.1
Lavens, D.2
Peelman, F.3
Eyckerman, S.4
Vandekerckhove, J.5
Tavernier, J.6
-
25
-
-
17844401180
-
Molecular and anatomical determinants of central leptin resistance
-
Munzberg H, Myers MG. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005; 8: 566-70.
-
(2005)
Nat Neurosci
, vol.8
, pp. 566-570
-
-
Munzberg, H.1
Myers, M.G.2
-
26
-
-
0030828823
-
Leptin activates PI3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
-
Kelerrer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 1997; 40: 1358-62.
-
(1997)
Diabetologia
, vol.40
, pp. 1358-1362
-
-
Kelerrer, M.1
Koch, M.2
Metzinger, E.3
Mushack, J.4
Capp, E.5
Haring, H.U.6
-
27
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 2005; 115: 951-8.
-
(2005)
J Clin Invest
, vol.115
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
28
-
-
0000430395
-
Divergent roles of SHP-2 in ERK activation by leptin receptors
-
Bjorbaek C, Buchholz RM, Davis SM, Bates SH, Pierroz DD. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 2001; 276: 4747-55.
-
(2001)
J Biol Chem
, vol.276
, pp. 4747-4755
-
-
Bjorbaek, C.1
Buchholz, R.M.2
Davis, S.M.3
Bates, S.H.4
Pierroz, D.D.5
-
29
-
-
0035816407
-
Insulin modulates leptin-induced STAT3 activation in rat hypothalamus
-
Carvalheira JB, Siloto RM, Ignacchitti I, Brenelli SL, Carvalho CR. Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS Lett 2001; 500: 119-24.
-
(2001)
FEBS Lett
, vol.500
, pp. 119-124
-
-
Carvalheira, J.B.1
Siloto, R.M.2
Ignacchitti, I.3
Brenelli, S.L.4
Carvalho, C.R.5
-
30
-
-
0037228018
-
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI3-kinase-mediated signaling in rat liver
-
Carvalheira JB, Ribeiro EB, Folli F, Velloso LA, Saad MJ. Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI3-kinase-mediated signaling in rat liver. Biol Chem 2003; 384: 151-9.
-
(2003)
Biol Chem
, vol.384
, pp. 151-159
-
-
Carvalheira, J.B.1
Ribeiro, E.B.2
Folli, F.3
Velloso, L.A.4
Saad, M.J.5
-
31
-
-
20644434143
-
Cross-talk between the insulin and leptin signaling systems in rat hypothalamus
-
Carvalheira JB, Torsoni MA, Ueno M, Amaral ME, Araujo EP, Velloso LA, et al. Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res 2005; 13: 48-57.
-
(2005)
Obes Res
, vol.13
, pp. 48-57
-
-
Carvalheira, J.B.1
Torsoni, M.A.2
Ueno, M.3
Amaral, M.E.4
Araujo, E.P.5
Velloso, L.A.6
-
32
-
-
0033849777
-
Obesity and insulin resistance
-
Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000; 106: 473-81.
-
(2000)
J Clin Invest
, vol.106
, pp. 473-481
-
-
Kahn, B.B.1
Flier, J.S.2
-
33
-
-
0018621289
-
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
-
Woods SC, Lotter EC, McKay LD, Porte D Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979; 282: 503-5.
-
(1979)
Nature
, vol.282
, pp. 503-505
-
-
Woods, S.C.1
Lotter, E.C.2
McKay, L.D.3
Porte Jr., D.4
-
34
-
-
0020065416
-
Insulin stimulates the phosphorilation of the 95,000-dalton subunit of its own receptor
-
Kasuga M, Karisson FA, Kahn CR. Insulin stimulates the phosphorilation of the 95,000-dalton subunit of its own receptor. Science 1982; 215: 185-7.
-
(1982)
Science
, vol.215
, pp. 185-187
-
-
Kasuga, M.1
Karisson, F.A.2
Kahn, C.R.3
-
35
-
-
0035856949
-
Insulin signaling and the regulation of glucose and lipid metabolism
-
Saltiel AR, Kahn CR. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
36
-
-
0030748457
-
The insulin signaling system and the IRS proteins
-
White MF. The insulin signaling system and the IRS proteins. Diabetologia 1997; 40: S2-17.
-
(1997)
Diabetologia
, vol.40
-
-
White, M.F.1
-
37
-
-
0038339520
-
Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold
-
Torsoni MA, Carvalheira JB, Pereira-Da Silva M, De Carvalho-Filho MA, Saad MJ, Velloso LA. Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. Am J Physiol Endocrinol Metab 2003; 285: E216-23.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Torsoni, M.A.1
Carvalheira, J.B.2
Pereira-Da Silva, M.3
De Carvalho-Filho, M.A.4
Saad, M.J.5
Velloso, L.A.6
-
38
-
-
0346216155
-
Selective impairment of insulin signaling in the hypothalamus of obese Zucker rats
-
Carvalheira JB, Ribeiro EB, Araujo EP, Guimaraes RB, Telles MM. Selective impairment of insulin signaling in the hypothalamus of obese Zucker rats. Diabetologia 2003; 46: 1629-40.
-
(2003)
Diabetologia
, vol.46
, pp. 1629-1640
-
-
Carvalheira, J.B.1
Ribeiro, E.B.2
Araujo, E.P.3
Guimaraes, R.B.4
Telles, M.M.5
-
40
-
-
0029786390
-
Insulin reduces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat
-
Saad MJ, Carvalho CR, Thirone AC, Velloso LA. Insulin reduces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. J Biol Chem 1996; 271: 22100-4.
-
(1996)
J Biol Chem
, vol.271
, pp. 22100-22104
-
-
Saad, M.J.1
Carvalho, C.R.2
Thirone, A.C.3
Velloso, L.A.4
-
41
-
-
0030737573
-
Effects of leptin on insulin sensitivity in normal rats
-
Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997; 138: 3395-401.
-
(1997)
Endocrinology
, vol.138
, pp. 3395-3401
-
-
Sivitz, W.I.1
Walsh, S.A.2
Morgan, D.A.3
Thomas, M.J.4
Haynes, W.G.5
-
42
-
-
33745576798
-
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
-
Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, et al. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci 2006; 9: 1-6.
-
(2006)
Nat Neurosci
, vol.9
, pp. 1-6
-
-
Kim, M.S.1
Pak, Y.K.2
Jang, P.G.3
Namkoong, C.4
Choi, Y.S.5
Won, J.C.6
-
43
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003; 423: 550-5.
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
Rhee, J.2
Donovan, J.3
Walkey, C.J.4
Yoon, J.C.5
Oriente, F.6
-
44
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
Kitamura T. Nakae J, Kitamura Y, Kido Y, Biggs WH III, Wright CV, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002; 110: 1839-47.
-
(2002)
J Clin Invest
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs III, W.H.5
Wright, C.V.6
-
45
-
-
0028029856
-
Insulin receptor substrate-1 (IRS1) distribution in the rat central nervous system
-
Folli F, Bonfanti L, Renard E, Kahn CR, Merighi A. Insulin receptor substrate-1 (IRS1) distribution in the rat central nervous system. J Neurosci 1994; 14: 6412-22.
-
(1994)
J Neurosci
, vol.14
, pp. 6412-6422
-
-
Folli, F.1
Bonfanti, L.2
Renard, E.3
Kahn, C.R.4
Merighi, A.5
-
46
-
-
0033599752
-
Insulin induces tyrosine phosphorylation of the insulin receptor and SHC, and SHC/GRB2 association in cerebellum but not in forebrain cortex of rats
-
De L.A. Fernandes ML, Saad MJ, Velloso LA. Insulin induces tyrosine phosphorylation of the insulin receptor and SHC, and SHC/GRB2 association in cerebellum but not in forebrain cortex of rats. Brain Res 1999; 826: 74-82.
-
(1999)
Brain Res
, vol.826
, pp. 74-82
-
-
De, L.A.1
Fernandes, M.L.2
Saad, M.J.3
Velloso, L.A.4
-
47
-
-
0242552065
-
Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats
-
Pereira-Da Silva M, Torsoni MA, Nourani HV, Augusto VD, Souza CT, Gasparetti AL, et al. Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology 2003; 144: 4831-40.
-
(2003)
Endocrinology
, vol.144
, pp. 4831-4840
-
-
Pereira-Da Silva, M.1
Torsoni, M.A.2
Nourani, H.V.3
Augusto, V.D.4
Souza, C.T.5
Gasparetti, A.L.6
-
48
-
-
0033458104
-
Effects of dexamethasone on the body weight set point of rats
-
Michel C, Cabanac M. Effects of dexamethasone on the body weight set point of rats. Physiol Behav 1999, 68: 145-50.
-
(1999)
Physiol Behav
, vol.68
, pp. 145-150
-
-
Michel, C.1
Cabanac, M.2
-
49
-
-
0033014744
-
Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat
-
Zakrzewska KE, Cusin I, Stricker-Krongrad A, Boss O, Ricquier D, Jeanrenaud B, et al. Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat. Diabetes 1999; 48: 365-70.
-
(1999)
Diabetes
, vol.48
, pp. 365-370
-
-
Zakrzewska, K.E.1
Cusin, I.2
Stricker-Krongrad, A.3
Boss, O.4
Ricquier, D.5
Jeanrenaud, B.6
-
50
-
-
0026795166
-
Glucocorticoids are required for food-deprivation-induced increases in hypothalamic neuropeptide Y expression
-
Ponsalle P, Srivistava LS, Uht RM, White JD. Glucocorticoids are required for food-deprivation-induced increases in hypothalamic neuropeptide Y expression. Neuroendocrinology 1993, 4: 585-91.
-
(1993)
Neuroendocrinology
, vol.4
, pp. 585-591
-
-
Ponsalle, P.1
Srivistava, L.S.2
Uht, R.M.3
White, J.D.4
-
51
-
-
0031039669
-
Elevated corticosterone is not required for the rapid induction of neuropeptide Y gene expression by an overnight fast
-
Hanson ES, Levin N, Dallman MF. Elevated corticosterone is not required for the rapid induction of neuropeptide Y gene expression by an overnight fast. Endocrinology 1997; 138: 1041-7.
-
(1997)
Endocrinology
, vol.138
, pp. 1041-1047
-
-
Hanson, E.S.1
Levin, N.2
Dallman, M.F.3
-
52
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, Gautam D, Burks DJ, Gillete J, Schubert M, Orban PC, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000; 289: 2122-5.
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillete, J.4
Schubert, M.5
Orban, P.C.6
-
53
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki E, Lipes MA, Patti ME, Bruning JC, Haag B, Johnson RS. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994; 372: 186-90.
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Bruning, J.C.4
Haag, B.5
Johnson, R.S.6
-
54
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers DJ, Gutiérrez JS, Towery H, Burks DJ, Ren JM, Previs S. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998; 391: 900-4.
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutiérrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
-
55
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-70.
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
57
-
-
0035654860
-
Leptin and the control of obesity
-
Wilding JP. Leptin and the control of obesity. Curr Opin Pharmacol 2001; 6: 656-61.
-
(2001)
Curr Opin Pharmacol
, vol.6
, pp. 656-661
-
-
Wilding, J.P.1
-
58
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996: 334: 292-5.
-
(1996)
N Engl J Med
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.4
Stephens, T.W.5
Nyce, M.R.6
-
59
-
-
0035514934
-
Partial leptin deficiency and human adiposity
-
Farooqi IS, Keogh JM, Kamath S, Jones S, Gibson WT, Trussell R, et al. Partial leptin deficiency and human adiposity. Nature 2001; 414: 34-5.
-
(2001)
Nature
, vol.414
, pp. 34-35
-
-
Farooqi, I.S.1
Keogh, J.M.2
Kamath, S.3
Jones, S.4
Gibson, W.T.5
Trussell, R.6
-
60
-
-
0030878110
-
Congenital leptin deficiency is associated with severe earlyonset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H Wareham NJ, et al. Congenital leptin deficiency is associated with severe earlyonset obesity in humans. Nature 1997; 387: 903-8.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
-
61
-
-
23844535138
-
Physical activity considerations for the treatment and prevention of obesity
-
Jakicic JM, Otto AM. Physical activity considerations for the treatment and prevention of obesity. Am J Clin Nutr 2005; 82: S226-9.
-
(2005)
Am J Clin Nutr
, vol.82
-
-
Jakicic, J.M.1
Otto, A.M.2
-
62
-
-
12844274354
-
Modulatory role of food, feeding regime and physical exercise on body weight and insulin resistance
-
Kretschmer BD, Schelling P, Norbert B, Liebscher C, Treutel S, Kruger N, et al. Modulatory role of food, feeding regime and physical exercise on body weight and insulin resistance. Life Sci 2005; 76: 1553-73.
-
(2005)
Life Sci
, vol.76
, pp. 1553-1573
-
-
Kretschmer, B.D.1
Schelling, P.2
Norbert, B.3
Liebscher, C.4
Treutel, S.5
Kruger, N.6
-
63
-
-
0036265048
-
The ability of habitual exercise to influence appetite and food intake in response to high- and low-energy preloads in man
-
Long SJ, Hart K, Morgan M. The ability of habitual exercise to influence appetite and food intake in response to high- and low-energy preloads in man. Br J Nutr 2002; 87: 517-23.
-
(2002)
Br J Nutr
, vol.87
, pp. 517-523
-
-
Long, S.J.1
Hart, K.2
Morgan, M.3
-
65
-
-
8744239147
-
The role of exercise for weight loss and maintenance
-
Donnely JE, Smith B, Jacobsen DJ, Kirk E, Du Bose K, Hyder M, et al. The role of exercise for weight loss and maintenance. Bets Pract Res Clin Gastroenterol 2004; 18: 1009-29.
-
(2004)
Bets Pract Res Clin Gastroenterol
, vol.18
, pp. 1009-1029
-
-
Donnely, J.E.1
Smith, B.2
Jacobsen, D.J.3
Kirk, E.4
Du Bose, K.5
Hyder, M.6
-
66
-
-
0036317019
-
Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway
-
Luciano E, Carneiro EM, Carvalho CR, Carvalheira JB, Peres SB, Reis MA, et al. Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol 2002; 147: 149-57.
-
(2002)
Eur J Endocrinol
, vol.147
, pp. 149-157
-
-
Luciano, E.1
Carneiro, E.M.2
Carvalho, C.R.3
Carvalheira, J.B.4
Peres, S.B.5
Reis, M.A.6
-
67
-
-
0032954067
-
Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes
-
Kennedy JW, Hirshman MF, Gervino EV, Ocel JV, Forse RA, Hoenig SJ, et al. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes 1999; 48: 1192-7.
-
(1999)
Diabetes
, vol.48
, pp. 1192-1197
-
-
Kennedy, J.W.1
Hirshman, M.F.2
Gervino, E.V.3
Ocel, J.V.4
Forse, R.A.5
Hoenig, S.J.6
-
68
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
Fowler, S.E.3
Hamman, R.F.4
Lachin, J.M.5
Walker, E.A.6
-
69
-
-
0031978984
-
Exercise, glucose transport, and insulin sensitivity
-
Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 1998; 49: 235-61.
-
(1998)
Annu Rev Med
, vol.49
, pp. 235-261
-
-
Goodyear, L.J.1
Kahn, B.B.2
-
70
-
-
0036021855
-
Invited review: Effects of acute exercise and exercise training on insulin resistance
-
Henriksen EJ. Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002; 93: 788-96.
-
(2002)
J Appl Physiol
, vol.93
, pp. 788-796
-
-
Henriksen, E.J.1
-
71
-
-
0036067028
-
Insulin signaling after exercise in insulin receptor substrate-2-deficient mice
-
Howlett KF, Sakamoto K, Hirshman MF, Aschenbach WG, Dow M, White MF, et al. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes 2002; 51: 479-83.
-
(2002)
Diabetes
, vol.51
, pp. 479-483
-
-
Howlett, K.F.1
Sakamoto, K.2
Hirshman, M.F.3
Aschenbach, W.G.4
Dow, M.5
White, M.F.6
-
72
-
-
0032697037
-
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice
-
Wojtaszewski JF, Higaki Y, Hirshman MF, Michael MD, Dufresne SD, Kahn CR, et al. Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. J Clin Invest 1999; 104: 1257-64.
-
(1999)
J Clin Invest
, vol.104
, pp. 1257-1264
-
-
Wojtaszewski, J.F.1
Higaki, Y.2
Hirshman, M.F.3
Michael, M.D.4
Dufresne, S.D.5
Kahn, C.R.6
-
73
-
-
0030853559
-
Meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention
-
Miller WC, Koceja DM, Hamilton EJA. Meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention. Int J Obes Relat Metab Disord 1997; 21: 941-7.
-
(1997)
Int J Obes Relat Metab Disord
, vol.21
, pp. 941-947
-
-
Miller, W.C.1
Koceja, D.M.2
Hamilton, E.J.A.3
-
74
-
-
33645732140
-
Physical activity and long-term maintenance of weight loss
-
Pronk NP, Wing RR, Hamilton EJ. Physical activity and long-term maintenance of weight loss. Obes Res 1994; 2: 587-91.
-
(1994)
Obes Res
, vol.2
, pp. 587-591
-
-
Pronk, N.P.1
Wing, R.R.2
Hamilton, E.J.3
-
75
-
-
0028818087
-
Lesion of central nucleus of amygdala promotes fat gain without preventing effect of exercise on energy balance
-
Bovetto S, Richard D. Lesion of central nucleus of amygdala promotes fat gain without preventing effect of exercise on energy balance. Am J Physiol 1995; 269: R781-6.
-
(1995)
Am J Physiol
, vol.269
-
-
Bovetto, S.1
Richard, D.2
-
76
-
-
0025118414
-
Involvement of corticotropin-releasing factor in the anorexia induced by exercise
-
Rivest S, Richard D. Involvement of corticotropin-releasing factor in the anorexia induced by exercise. Brain Res Bull 1990; 25: 169-72.
-
(1990)
Brain Res Bull
, vol.25
, pp. 169-172
-
-
Rivest, S.1
Richard, D.2
-
77
-
-
33745224150
-
Integration of feeding and spontaneous physical activity: Role for orexin
-
Kotz CM. Integration of feeding and spontaneous physical activity: role for orexin. Physiol Behav 2006; 88: 294-301.
-
(2006)
Physiol Behav
, vol.88
, pp. 294-301
-
-
Kotz, C.M.1
-
78
-
-
33749170808
-
Eje hipotálamo-pituitario: Efectos del entrenamiento físico en ratas Wistar con administración de dexametasona
-
Pauli JR, Gomes RJ, Luciano E. Eje hipotálamo-pituitario: efectos del entrenamiento físico en ratas Wistar con administración de dexametasona. Rev Neurol 2006; 42: 325-31.
-
(2006)
Rev Neurol
, vol.42
, pp. 325-331
-
-
Pauli, J.R.1
Gomes, R.J.2
Luciano, E.3
-
79
-
-
0031019661
-
Brain monoamines, exercise, and behavioral stress: Animal models
-
Dishman RK. Brain monoamines, exercise, and behavioral stress: animal models. Med Sci Sports Exerc 1997; 29: 63-74.
-
(1997)
Med Sci Sports Exerc
, vol.29
, pp. 63-74
-
-
Dishman, R.K.1
-
80
-
-
0010330438
-
Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
-
Neeper SA, Gómez-Pinilla F, Choi J, Cotman CW. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 1996; 726: 49-56.
-
(1996)
Brain Res
, vol.726
, pp. 49-56
-
-
Neeper, S.A.1
Gómez-Pinilla, F.2
Choi, J.3
Cotman, C.W.4
-
81
-
-
0021717476
-
Chronic norepinephrine injection into the hypothalamic paraventricular nucleus produces hyperphagia and increased body weight in the rat
-
Leibowitz SF, Roossin P, Rosenn M. Chronic norepinephrine injection into the hypothalamic paraventricular nucleus produces hyperphagia and increased body weight in the rat. Pharmacol Biochem Behav 1984; 21: 801-8.
-
(1984)
Pharmacol Biochem Behav
, vol.21
, pp. 801-808
-
-
Leibowitz, S.F.1
Roossin, P.2
Rosenn, M.3
-
82
-
-
0019582884
-
Increased food intake, body weight, and adiposity in rats after regional neurochemical depletion of serotonin
-
Waldbillig RJ, Bartness TJ, Stanley BG. Increased food intake, body weight, and adiposity in rats after regional neurochemical depletion of serotonin. J Comp Physiol Psychol 1981; 95: 391-405.
-
(1981)
J Comp Physiol Psychol
, vol.95
, pp. 391-405
-
-
Waldbillig, R.J.1
Bartness, T.J.2
Stanley, B.G.3
-
83
-
-
0033592920
-
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
-
Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A 1999; 96: 15239-44.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 15239-15244
-
-
Lyons, W.E.1
Mamounas, L.A.2
Ricaurte, G.A.3
Coppola, V.4
Reid, S.W.5
Bora, S.H.6
-
84
-
-
15444363197
-
Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima fatty rats: Role of hypothalamic signaling
-
Bi S, Scott KA, Hyun J, Ladenheim EE, Moran TH. Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima fatty rats: role of hypothalamic signaling. Endocrinology 2005; 146: 1676-85.
-
(2005)
Endocrinology
, vol.146
, pp. 1676-1685
-
-
Bi, S.1
Scott, K.A.2
Hyun, J.3
Ladenheim, E.E.4
Moran, T.H.5
-
85
-
-
0038306201
-
Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats
-
Shin MS, Kim H, Chang HK, Lee TH, Jang MH, Shin MC, et al. Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats. Neurosci Lett 2003; 346: 157-60.
-
(2003)
Neurosci Lett
, vol.346
, pp. 157-160
-
-
Shin, M.S.1
Kim, H.2
Chang, H.K.3
Lee, T.H.4
Jang, M.H.5
Shin, M.C.6
-
86
-
-
33750591273
-
Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats
-
Flores MB, Fernandes MF, Ropelle ER, Faria MC, Ueno M, Velloso LA, et al. Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes 2006; 55: 2554-61.
-
(2006)
Diabetes
, vol.55
, pp. 2554-2561
-
-
Flores, M.B.1
Fernandes, M.F.2
Ropelle, E.R.3
Faria, M.C.4
Ueno, M.5
Velloso, L.A.6
-
87
-
-
2942702298
-
The metabolic role of IL-6 produced during exercise: Is IL-6 an exercise factor?
-
Pedersen BK, Steenberg A, Fischer C, Keller C, Keller P, Plomgaard P, et al. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proc Nutr Soc 2004; 63: 263-7.
-
(2004)
Proc Nutr Soc
, vol.63
, pp. 263-267
-
-
Pedersen, B.K.1
Steenberg, A.2
Fischer, C.3
Keller, C.4
Keller, P.5
Plomgaard, P.6
-
88
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, et al. Hypothalamic mTOR signaling regulates food intake. Science 2006; 312: 927-30.
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
-
89
-
-
34147159710
-
-
Febbraio MA. gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest 2007; 117: 841-9.
-
Febbraio MA. gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest 2007; 117: 841-9.
-
-
-
-
90
-
-
33746075210
-
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
-
Janoschek R, Plum L, Koch L, Munzberg H, Diano S, Bruning JC. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proc Natl Acad Sci U S A 2006; 103: 10707-12.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 10707-10712
-
-
Janoschek, R.1
Plum, L.2
Koch, L.3
Munzberg, H.4
Diano, S.5
Bruning, J.C.6
-
91
-
-
0346157324
-
Acquiring signaling specificity from the receptor gp130
-
Ernst M, Jenkins BJ. Acquiring signaling specificity from the receptor gp130. Trends Genet 2004; 20: 23-32.
-
(2004)
Trends Genet
, vol.20
, pp. 23-32
-
-
Ernst, M.1
Jenkins, B.J.2
-
92
-
-
0029860791
-
Modulation of insulin activities by leptin
-
Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-8.
-
(1996)
Science
, vol.274
, pp. 1185-1188
-
-
Cohen, B.1
Novick, D.2
Rubinstein, M.3
-
93
-
-
0028279791
-
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
-
Boulton TG, Stahl N, Yancopoulos GD. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 1994; 269: 11648-55.
-
(1994)
J Biol Chem
, vol.269
, pp. 11648-11655
-
-
Boulton, T.G.1
Stahl, N.2
Yancopoulos, G.D.3
|