Arecoline-induced growth arrest and p21WAF1 expression are dependent on p53 in rat hepatocytes

Toxicology

Volumn 243, Issue 1-2, 2008, Pages 1-10

  Chou, Wen Wen ^a   Guh, Jinn Yuh ^a,b   Tsai, Jung Fa ^a,b   Hwang, Chi Ching ^a   Chen, Hung Chun ^a,b   Huang, Jau Shyang ^c   Yang, Yu Lin ^c   Hung, Wen Chun ^d   Chuang, Lea Yea ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Areca catechu; Cell cycle; Cytotoxicity; Genotoxicity; Hepatocyte

Indexed keywords

ARECOLINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; MESSENGER RNA; PIFITHRIN ALPHA; PROTEIN P53; SERINE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; BETEL NUT; CELL CLONE; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; GROWTH INHIBITION; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; TIME; TOXICITY TESTING; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; ARECA; ARECOLINE; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; MUTAGENS; RATS; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53;

ARECA CATECHU; MUS; PIPER BETEL; RATTUS;

EID: 37049024088     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.09.003     Document Type: Article

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