Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin

Toxicology and Applied Pharmacology

Volumn 226, Issue 1, 2008, Pages 30-37

  Kalra, Neetu ^a   Bhui, Kulpreet ^a   Roy, Preeti ^a   Srivastava, Smita ^a   George, Jasmine ^a   Prasad, Sahdeo ^a   Shukla, Yogeshwer ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Apoptosis; Bromelain; Cox 2; MAPK; Mouse skin; NF B

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; BROMELAIN; CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; FEMALE; FRUIT; METASTASIS INHIBITION; MOUSE; NONHUMAN; PINEAPPLE; PLANT STEM; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SKIN PAPILLOMA; THROMBOSIS; TUMOR VOLUME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BROMELAINS; CYCLOOXYGENASE 2; FEMALE; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SKIN; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEIN P53;

ANANAS; ANANAS COMOSUS;

EID: 36849030829     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.08.012     Document Type: Article

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