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Volumn 6, Issue 6, 2006, Pages 908-915

Enhancement of cytokine-mediated NF-κB activation by phosphatidylinositol 3-kinase inhibitors in monocytic cells

Author keywords

Interleukin 1; Nuclear factor B; Phosphatidylinositol 3 kinase; THP 1; Tumor necrosis factor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; CYCLOOXYGENASE 2; CYTOKINE; DNA; I KAPPA B; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; LY 303511; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 33646087878     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2006.01.007     Document Type: Article
Times cited : (28)

References (23)
  • 1
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle P.A., and Henkel T. Function and activation of NF-κB in the immune system. Annu Rev Immunol 12 (1994) 141-179
    • (1994) Annu Rev Immunol , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 2
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden M.S., and Ghosh S. Signaling to NF-κB. Genes Dev 18 (2004) 2195-2224
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 3
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation
    • Viatour P., Merville M.P., Bours V., and Chariot A. Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Trends Biochem Sci 30 (2005) 43-52
    • (2005) Trends Biochem Sci , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 4
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2 (2002) 489-501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 0442323485 scopus 로고    scopus 로고
    • LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism
    • Choi E.K., Park H.J., Ma J.S., Lee H.C., Kang H.C., Kim B.G., et al. LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Lett 559 (2004) 141-144
    • (2004) FEBS Lett , vol.559 , pp. 141-144
    • Choi, E.K.1    Park, H.J.2    Ma, J.S.3    Lee, H.C.4    Kang, H.C.5    Kim, B.G.6
  • 7
    • 0030695187 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NF-κB and AP-1 activation
    • Reddy S.A., Huang J.H., and Liao W.S. Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NF-κB and AP-1 activation. J Biol Chem 272 (1997) 29167-29173
    • (1997) J Biol Chem , vol.272 , pp. 29167-29173
    • Reddy, S.A.1    Huang, J.H.2    Liao, W.S.3
  • 8
    • 0033517189 scopus 로고    scopus 로고
    • NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes O.N., Mayo L.D., Gustin J.A., Pfeffer S.R., Pfeffer L.M., Donner D.B., et al. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401 (1999) 82-85
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 9
    • 0345826140 scopus 로고    scopus 로고
    • Cell type-specific expression of the IκB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-κB activation
    • Gustin J.A., Ozes O.N., Akca H., Pincheira R., Mayo L.D., Li Q., et al. Cell type-specific expression of the IκB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-κB activation. J Biol Chem 279 (2004) 1615-1620
    • (2004) J Biol Chem , vol.279 , pp. 1615-1620
    • Gustin, J.A.1    Ozes, O.N.2    Akca, H.3    Pincheira, R.4    Mayo, L.D.5    Li, Q.6
  • 10
    • 0033563141 scopus 로고    scopus 로고
    • Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages
    • Diaz-Guerra M.J., Castrillo A., Martin-Sanz P., and Bosca L. Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages. J Immunol 162 (1999) 6184-6190
    • (1999) J Immunol , vol.162 , pp. 6184-6190
    • Diaz-Guerra, M.J.1    Castrillo, A.2    Martin-Sanz, P.3    Bosca, L.4
  • 11
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha M., and Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 277 (2002) 32124-32132
    • (2002) J Biol Chem , vol.277 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 12
    • 22544445221 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4
    • Aksoy E., Vanden Berghe W., Detienne S., Amraoui Z., Fitzgerald K.A., Haegeman G., et al. Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4. Eur J Immunol 35 (2005) 2200-2209
    • (2005) Eur J Immunol , vol.35 , pp. 2200-2209
    • Aksoy, E.1    Vanden Berghe, W.2    Detienne, S.3    Amraoui, Z.4    Fitzgerald, K.A.5    Haegeman, G.6
  • 13
    • 0035115257 scopus 로고    scopus 로고
    • S6K is differentially inhibited by LY294002 and wortmannin
    • S6K is differentially inhibited by LY294002 and wortmannin. Endocrinology 142 (2001) 498-501
    • (2001) Endocrinology , vol.142 , pp. 498-501
    • Adi, S.1    Wu, N.Y.2    Rosenthal, S.M.3
  • 14
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos C.J., Matter W.F., Hui K.Y., and Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269 (1994) 5241-5248
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 15
    • 8044257699 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
    • Blommaart E.F., Krause U., Schellens J.P., Vreeling-Sindelarova H., and Meijer A.J. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 243 (1997) 240-246
    • (1997) Eur J Biochem , vol.243 , pp. 240-246
    • Blommaart, E.F.1    Krause, U.2    Schellens, J.P.3    Vreeling-Sindelarova, H.4    Meijer, A.J.5
  • 16
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
    • Schmedtje Jr. J.F., Ji Y.S., Liu W.L., DuBois R.N., and Runge M.S. Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272 (1997) 601-608
    • (1997) J Biol Chem , vol.272 , pp. 601-608
    • Schmedtje Jr., J.F.1    Ji, Y.S.2    Liu, W.L.3    DuBois, R.N.4    Runge, M.S.5
  • 17
    • 0034077529 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade
    • Lasa M., Mahtani K.R., Finch A., Brewer G., Saklatvala J., Clark A.R., et al. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol 20 (2000) 4265-4274
    • (2000) Mol Cell Biol , vol.20 , pp. 4265-4274
    • Lasa, M.1    Mahtani, K.R.2    Finch, A.3    Brewer, G.4    Saklatvala, J.5    Clark, A.R.6
  • 18
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
    • Delhase M., Hayakawa M., Chen Y., and Karin M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284 (1999) 309-313
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 19
    • 0141532262 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S. Toll-like receptor signaling. J Biol Chem 278 (2003) 38105-38108
    • (2003) J Biol Chem , vol.278 , pp. 38105-38108
    • Akira, S.1
  • 20
    • 0037204948 scopus 로고    scopus 로고
    • TNF-R1 signaling: a beautiful pathway
    • Chen G., and Goeddel D.V. TNF-R1 signaling: a beautiful pathway. Science 296 (2002) 1634-1635
    • (2002) Science , vol.296 , pp. 1634-1635
    • Chen, G.1    Goeddel, D.V.2
  • 21
    • 14044277556 scopus 로고    scopus 로고
    • Redox regulation of NF-κB activation: distinct redox regulation between the cytoplasm and the nucleus
    • Kabe Y., Ando K., Hirao S., Yoshida M., and Handa H. Redox regulation of NF-κB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal 7 (2005) 395-403
    • (2005) Antioxid Redox Signal , vol.7 , pp. 395-403
    • Kabe, Y.1    Ando, K.2    Hirao, S.3    Yoshida, M.4    Handa, H.5
  • 22
    • 0036177671 scopus 로고    scopus 로고
    • Cyclooxygenase-2: a therapeutic target
    • Turini M.E., and DuBois R.N. Cyclooxygenase-2: a therapeutic target. Annu Rev Med 53 (2002) 35-57
    • (2002) Annu Rev Med , vol.53 , pp. 35-57
    • Turini, M.E.1    DuBois, R.N.2
  • 23
    • 0037031924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
    • Monick M.M., Robeff P.K., Butler N.S., Flaherty D.M., Carter A.B., Peterson M.W., et al. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem 277 (2002) 32992-33000
    • (2002) J Biol Chem , vol.277 , pp. 32992-33000
    • Monick, M.M.1    Robeff, P.K.2    Butler, N.S.3    Flaherty, D.M.4    Carter, A.B.5    Peterson, M.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.