Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase

Biochemistry

Volumn 39, Issue 7, 2000, Pages 1771-1777

  Digits, Jennifer A ^a   Hedstrom, Lizbeth ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; TIAZOFURIN;

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG RESISTANCE; DRUG SELECTIVITY; GENE MUTATION; PRIORITY JOURNAL; TRICHOMONAS FOETUS;

ADENOSINE DIPHOSPHATE; ANIMALS; CRICETINAE; CRICETULUS; DRUG RESISTANCE; DRUG SYNERGISM; ENZYME INHIBITORS; HUMANS; IMP DEHYDROGENASE; MUTAGENESIS, SITE-DIRECTED; MYCOPHENOLIC ACID; NAD; RIBAVIRIN; SPECTROMETRY, FLUORESCENCE; TRITRICHOMONAS FOETUS; TRYPTOPHAN;

MAMMALIA; TRICHOMONAS; TRITRICHOMONAS FOETUS;

EID: 0034700967     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992288e     Document Type: Article

References (29)

1. Kaplan, A. H., Michael, S. F., Wehbie, R. S., Knigge, M. F., Paul, D. A., Everitt, L., Kempf, D. J., Norbeck, D. W., Erickson, J. W., and Swanstrom, R. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 5597-5601.
2. Smidt, M. L., Potts, K. E., Tucker, S. P., Blystone, L., Stiebel, T. R., Stallings, W. C., McDonald, J. J., Pillay, D., Richman, D. D. and Bryant, M. L. (1997) Antimicrob. Agents Chemother. 41, 515-522.
3. Tong, Y., Liu-Chen, X., Ercikan-Abali, E. A., Capiaux, G. M., Zhao, S., Banerjee, D., and Bertino, J. R. (1998) J. Biol. Chem. 273, 11611-11618.
4. Ho, D. D., Toyoshima, T. Hongmei, M., Kempf, D. J., Norbeck, D., Chen, C., Wideburg, N. E., Burt, S. K., Erickson, J. W., and Singh, M. K. (1994) J. Virol. 68, 2016-2020.
5. Jacobsen, H., Yasargil, K., Winslow, D. L., Craig, J. C., Krohn, A., Duncan, I. B., and Mous, J. (1995) Virology 206, 527-534.
6. Collins, J. R., Burt, S. K., and Erickson. J. W. (1995) Struct. Biol. 2, 334-338.
7. Erickson, J. W. (1995) Nat. Struct. Biol. 2, 523-529.
8. Farazi, T., Leichman, J., Harris, T., Gaboon, M., and Hedstrom, L. (1997) J. Biol. Chem. 272, 961-965.
9. Digits, J. A., and Hedstrom, L. (1999) Biochemistry 38, 15388-15397.
10. Sintchak, M. D., Fleming, M. A., Futer, O., Raybuck, S. A., Chambers, S. P., Caron, P. R., Murcko, M. A., and Wilson, K. P. (1996) Cell 85, 921-930.
11. Link, J. O., and Straub, K. (1996) J. Am, Chem. Soc. 118, 2091-2092.
12. Hedstrom, L., and Wang, C. C. (1990) Biochemistry 29, 849-554.
13. Wu, J. C., Carr, S. F., Antonino, L. C., Papp, E., and Pease, J. H. B. (1995) FASEB Abstr. 9, 472.
14. Fleming, M. A., Chambers, S. P., Connelly, P. R., Nimmersgen, E., Fox, T., Bruzzese, F. J., Hoe, F. J., Fulghem, J. R., Livingston, D. J., Stuver, C. M., Sintchak, M. D., Wilson, K. P., and Thomson, J. A. (1996) Biochemistry 35, 6990-6997.
15. Whitby, F. G., Luecke, H., Kuhn, P., Somoza, J. R., Huete-Perez, J. A., Phillips, J. D., Hill, C. P., Fletterick, R. J., and Wang, C. C. (1997) Biochemistry 36, 10666-10674.
16. Colby, T. D., Vanderveen, K., Strickler, M. D., Markham, G. D., and Goldstein, B. M. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 3531-3536.
17. Zhang, R., Evans, G., Rotella, F. J., Westbrook, E. M., Beno, D., Huberman, E., Joachimiak, A., and Collart, F. R. (1999) Biochemistry 38, 4691-4700.
18. Digits, J. A., and Hedstrom, L.( 1999) Biochemistry 38, 2295-2306.
19. Cleland, W. W. (1963) Biochim. Biophys. Acta 67, 104-137.
20. Marquez, V. E., Tseng, C. K. H., Gebeyehu, G., Cooney, D. A., Ahluwalia, G. S., Kelley, J. A., Dalal, M., Fuller, R. W., Wilson, Y. A., and Johns. D. G. (1986) J. Med. Chem. 29, 1726-1731.
21. Hager, R. W., Collant, F. R., Huberman, E., and Mitchell, B. S. (1995) Biochem. Phamacol. 49, 1323-1329.
22. Yamada, Y., Natsumeda, Y., and Weber, G. (1988) Biochemistry 27, 2193-2196.
23. Jencks, W. P. (1981 ) Proc. Natl. Acad. Sci. U.S.A. 78, 4046-4050.
24. Nakamura, C. E., and Abeles, R. H. (1985) Biochemistry 24, 1364-1376.
25. Schimerlik, M. I., and Cleland, W. W. (1977) Biochemistry 16, 565-570.
26. Northrop, D. B., and Cleland, W. W. (1974) J. Biol. Chem. 249, 2928-2931.
27. Cleland, W. W. (1997) Adv. Enzymol. Relat. Areas Mol. Biol. 45, 273-387.
28. Yonetani, T., and Theorell, H. (1964) Arch. Biochem. Biophys. 106, 2193-2196.
29. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.