STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells

Experimental Cell Research

Volumn 314, Issue 2, 2008, Pages 377-386

  Onishi, Akiko ^a   Chen, Qianming ^a   Humtsoe, Joseph O ^a   Kramer, Randall H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cadherin; Intercellular adhesion; STAT3

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE; STAT1 PROTEIN; STAT3 PROTEIN; UVOMORULIN;

ARTICLE; CANCER CELL; CELL ADHESION; CELL AGGREGATION; CELL CONTACT; CONTROLLED STUDY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; MOUTH CARCINOMA; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

EID: 36749080969     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.09.018     Document Type: Article

References (50)

1. Darnell Jr. J.E. STATs and gene regulation. Science 277 (1997) 1630-1635
2. Fukada T., Hibi M., Yamanaka Y., Takahashi-Tezuka M., Fujitani Y., Yamaguchi T., Nakajima K., and Hirano T. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5 (1996) 449-460
3. Li L., and Shaw P.E. Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines. J. Biol. Chem. 277 (2002) 17397-17405
4. Gross M., Liu B., Tan J., French F.S., Carey M., and Shuai K. Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells. Oncogene 20 (2001) 3880-3887
5. Epling-Burnette P.K., Liu J.H., Catlett-Falcone R., Turkson J., Oshiro M., Kothapalli R., Li Y., Wang J.M., Yang-Yen H.F., Karras J., Jove R., and Loughran Jr. T.P. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J. Clin. Invest. 107 (2001) 351-362
6. Song L., Turkson J., Karras J.G., Jove R., and Haura E.B. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene 22 (2003) 4150-4165
7. Kim E.J., Park J.I., and Nelkin B.D. IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. J. Biol. Chem. 280 (2005) 4913-4920
8. Grandis J.R., Drenning S.D., Zeng Q., Watkins S.C., Melhem M.F., Endo S., Johnson D.E., Huang L., He Y., and Kim J.D. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 4227-4232
9. Zhong Z., Wen Z., and Darnell Jr. J.E. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264 (1994) 95-98
10. Cao X., Tay A., Guy G.R., and Tan Y.H. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 16 (1996) 1595-1603
11. Vignais M.L., and Gilman M. Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system. Mol. Cell. Biol. 19 (1999) 3727-3735
12. Niu G., Wright K.L., Huang M., Song L., Haura E., Turkson J., Zhang S., Wang T., Sinibaldi D., Coppola D., Heller R., Ellis L.M., Karras J., Bromberg J., Pardoll D., Jove R., and Yu H. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21 (2002) 2000-2008
13. Turkson J., Bowman T., Garcia R., Caldenhoven E., De Groot R.P., and Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol. Cell. Biol. 18 (1998) 2545-2552
14. Bromberg J., and Darnell Jr. J.E. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19 (2000) 2468-2473
15. Amin H.M., McDonnell T.J., Ma Y., Lin Q., Fujio Y., Kunisada K., Leventaki V., Das P., Rassidakis G.Z., Cutler C., Medeiros L.J., and Lai R. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene 23 (2004) 5426-5434
16. Zhang F., Li C., Halfter H., and Liu J. Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 22 (2003) 894-905
17. Mehlen P., and Puisieux A. Metastasis: a question of life or death. Nat. Rev., Cancer 6 (2006) 449-458
18. Kantak S.S., and Kramer R.H. E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells. J. Biol. Chem. 273 (1998) 16953-16961
19. Fouquet S., Lugo-Martinez V.H., Faussat A.M., Renaud F., Cardot P., Chambaz J., Pincon-Raymond M., and Thenet S. Early loss of E-cadherin from cell-cell contacts is involved in the onset of Anoikis in enterocytes. J. Biol. Chem. 279 (2004) 43061-43069
20. Kang H.G., Jenabi J.M., Zhang J., Keshelava N., Shimada H., May W.A., Ng T., Reynolds C.P., Triche T.J., and Sorensen P.H. E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res. 67 (2007) 3094-3105
21. Hofmann C., Obermeier F., Artinger M., Hausmann M., Falk W., Schoelmerich J., Rogler G., and Grossmann J. Cell-cell contacts prevent anoikis in primary human colonic epithelial cells. Gastroenterology 132 (2007) 587-600
22. Steinman R.A., Wentzel A., Lu Y., Stehle C., and Grandis J.R. Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2. Oncogene 22 (2003) 3608-3615
23. Anagnostopoulou A., Vultur A., Arulanandam R., Cao J., Turkson J., Jove R., Kim J.S., Glenn M., Hamilton A.D., and Raptis L. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer Lett. 242 (2006) 120-132
24. Boukamp P., Petrussevska R.T., Breitkreutz D., Hornung J., Markham A., and Fusenig N.E. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106 (1988) 761-771
25. Momose F., Araida T., Negishi A., Ichijo H., Shioda S., and Sasaki S. Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas. J. Oral. Pathol. Med. 18 (1989) 391-395
26. Jetten A.M., Kim J.S., Sacks P.G., Rearick J.I., Lotan D., Hong W.K., and Lotan R. Inhibition of growth and squamous-cell differentiation markers in cultured human head and neck squamous carcinoma cells by beta-all-trans retinoic acid. Int. J. Cancer 45 (1990) 195-202
27. Volberg T., Geiger B., Kartenbeck J., and Franke W.W. Changes in membrane-microfilament interaction in intercellular adherens junctions upon removal of extracellular Ca2+ ions. J. Cell Biol. 102 (1986) 1832-1842
28. Fry D.W., Bridges A.J., Denny W.A., Doherty A., Greis K.D., Hicks J.L., Hook K.E., Keller P.R., Leopold W.R., Loo J.A., McNamara D.J., Nelson J.M., Sherwood V., Smaill J.B., Trumpp-Kallmeyer S., and Dobrusin E.M. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 12022-12027
29. Levy D.E., and Darnell Jr. J.E. Stats: transcriptional control and biological impact. Nat. Rev., Mol. Cell Biol. 3 (2002) 651-662
30. Calo V., Migliavacca M., Bazan V., Macaluso M., Buscemi M., Gebbia N., and Russo A. STAT proteins: from normal control of cellular events to tumorigenesis. J. Cell. Physiol. 197 (2003) 157-168
31. Xi S., Gooding W.E., and Grandis J.R. In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene 24 (2005) 970-979
32. Lord J.D., McIntosh B.C., Greenberg P.D., and Nelson B.H. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5. J. Immunol. 164 (2000) 2533-2541
33. Vultur A., Cao J., Arulanandam R., Turkson J., Jove R., Greer P., Craig A., Elliott B., and Raptis L. Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene 23 (2004) 2600-2616
34. Mattila E., Pellinen T., Nevo J., Vuoriluoto K., Arjonen A., and Ivaska J. Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP. Nat. Cell Biol. 7 (2005) 78-85
35. Sun S., and Steinberg B.M. PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. J. Gen. Virol. 83 (2002) 1651-1658
36. Zhang X., Blenis J., Li H.C., Schindler C., and Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267 (1995) 1990-1994
37. Wen Z., and Darnell Jr. J.E. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 25 (1997) 2062-2067
38. Turkson J., and Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19 (2000) 6613-6626
39. Murray P.J. The JAK-STAT signaling pathway: input and output integration. J. Immunol. 178 (2007) 2623-2629
40. Silva C.M. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 23 (2004) 8017-8023
41. Quadros M.R., Peruzzi F., Kari C., and Rodeck U. Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes. Cancer Res. 64 (2004) 3934-3939
42. Olayioye M.A., Beuvink I., Horsch K., Daly J.M., and Hynes N.E. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J. Biol. Chem. 274 (1999) 17209-17218
43. Ren Z., and Schaefer T.S. ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. J. Biol. Chem. 277 (2002) 38486-38493
44. Sriuranpong V., Park J.I., Amornphimoltham P., Patel V., Nelkin B.D., and Gutkind J.S. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. 63 (2003) 2948-2956
45. Wheelock M.J., and Johnson K.R. Cadherin-mediated cellular signaling. Curr. Opin. Cell Biol. 15 (2003) 509-514
46. Pece S., and Gutkind J.S. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J. Biol. Chem. 275 (2000) 41227-41233
47. Liu W.F., Nelson C.M., Pirone D.M., and Chen C.S. E-cadherin engagement stimulates proliferation via Rac1. J. Cell Biol. 173 (2006) 431-441
48. Hulit J., Suyama K., Chung S., Keren R., Agiostratidou G., Shan W., Dong X., Williams T.M., Lisanti M.P., Knudsen K., and Hazan R.B. N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation. Cancer Res. 67 (2007) 3106-3116
49. Nakamura T., Kato Y., Fuji H., Horiuchi T., Chiba Y., and Tanaka K. E-cadherin-dependent intercellular adhesion enhances chemoresistance. Int. J. Mol. Med. 12 (2003) 693-700
50. Shen X., and Kramer R.H. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am. J. Pathol. 165 (2004) 1315-1329