Approaches to acrylamide physiologically based toxicokinetic modeling for exploring child-adult dosimetry differences

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 24, 2007, Pages 2033-2055

  Walker, Katherine ^a   Hattis, Dale ^a   Russ, Abel ^a   Sonawane, Bob ^b   Ginsberg, Gary ^c  

^a CLARK UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c Connecticut Department of Public Health ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; CYTOCHROME P450 2E1; DNA; EPOXIDE HYDROLASE; GLUTATHIONE; GLYCIDAMIDE;

AREA UNDER THE CURVE; ARTICLE; CALIBRATION; DNA ADDUCT; DOSIMETRY; LIVER MICROSOME METABOLISM; METABOLIC CAPACITY; MONTE CARLO METHOD; PRIORITY JOURNAL; TOXICOKINETICS;

ACRYLAMIDE; ADOLESCENT; ADULT; ANIMALS; CHILD; CHILD, PRESCHOOL; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; FOOD CONTAMINATION; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; INFANT; INFANT, NEWBORN; LIVER; MODELS, BIOLOGICAL; MONTE CARLO METHOD; RATS;

RATTUS;

EID: 36749060059     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390701601202     Document Type: Article

References (103)

1. Alcorn, J., and McNamara, P. J. 2002. Ontogeny of hepatic and renal systemic clearance pathways in infants. Part II. Clin. Pharmacokinet. 41:1077-1094.
2. Altman, P. L., and Dittmer, D. S. 1962. Growth including reproduction and morphological development. Washington, D.: Federation of American Scientists for Experimental Biology.
3. Andersen, M. E., Scimeca, J., and Olin, S. S. 2005. Kinetic and mechanistic data needs for a human physiologically based pharmacokinetic model for acrylamide. Adv. Exp. Med. Biol. 561:117-125.
4. Beckett, G. J., Howie, A. F., Hume, R., Matharoo B.,, Hiley, C., Jones, P., and Strange, R. C. 1990. Human glutathione S-transferases: Radioimmunoassay studies on the expression of alpha-, mu- and pi-class isoenzymes in developing lung and kidney. Biochim. Biophys. Acta 1036:176-182.
5. Bergmark, E., Calleman, C. J., and Costa, L. G. 1991. Formation of hemoglobin adducts of acrylamide and its epoxice metabolite glycidamide in the rat. Toxicol. Appl. Pharmacol. 111:352-363.
6. Besaratinia, A., and Pfeifer, G. P. 2004. Genotoxicity of acrylamide and glycidamide. JNCI 96:1023-1029.
7. Boettcher, M. I., Schettgen, T., Kutting, B., Pischetsrieder, M., and Angerer, J. 2005. Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population. Mutat. Res. 580:167-176.
8. Burk, R., and Hill, K. 1995. Reduced glutathione release into rat plasma by extrahepatic tissues. Am. J. Physiol. 269:G396-G399.
9. Calleman, C. J., Wu, Y., Tan, G., Bergmark, E., Zhang, S., Deng, H., Wang, Y., Crofton, K. M., Fennell, T., and Costa, L. G. 1994. Relationships between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. Toxicol. Appl. Pharmacol. 126:361-367.
10. Calleman, C. J. 1996. The metabolism and pharmacokinetics of acrylamide: Implications for mechanisms of toxicity and human risk estimation. Drug Metab. Rev. 28:527-590.
11. Center for the Evaluation of Risks to Human Reproduction. 2004. NTPCERHR Expert Panel report on the reproductive and developmental toxicity of acrylamide. Washington, DC: National Toxicology Program, U. S. Department of Health and Human Services.
12. Chantry, C. J., Rodriguez, J. L., Febo, I., Diaz, C., and Rodriguez-Orengo, J. F. 1999. Plasma glutathione concentrations in non-infected infants born from HIV-infected mothers: Developmental profile. Puerto Rican Health Sci. J. 18:267-272.
13. Clewell, H. J., Teeguarden, J., McDonald, J. T., Sarangapani, R., Lawrence, G., Covington, T., Gentry, R., and Shipp, A. 2002. Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Crit. Rev. Toxicol. 32:329-389.
14. Clewell, H. J., Gentry, P. R., Covington, T. R., Saragnapani, R., Teeguarden, J. G. 2004. Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Toxicol. Sci. 79:381-393.
15. Costa, L. G., Deng, H., Gregotti, C., Manzo, L., Faustman, E. M., Bergmark, E., and Calleman, C. J. 1992. Comparative studies on the neuro- and reproductive toxicity of acrylamide and its epoxide metabolite glycidamide in the rat. Neurotoxicology 13:219-224.
16. Cresteil, T., Beaune, P., Kremers, P., Celier, C., Guengerich, F. P., and Leroux, J.-P. 1985. Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes. Eur. J. Biochem. 151:345-350.
17. Cresteil, T. 1998. Onset of xenobiotic metabolism in children: Toxicological implications. Food Addit. Contam. 15(Suppl.):45-51.
18. D'Souza, R. W., Francis, W. R., and Andersen, M. E. 1988. Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure. J. Pharmacol. Exp. Ther. 245:563-568.
19. 3H]diisopropylfluorophosphate ([3H]DFP) method. Fundam. Appl. Toxicol. 9:271-276.
20. DiNovi, M., and Howard, D. 2004. The updated exposure assessment for acrylamide. Presentation at the JIFSAN meeting entitled "Acrylamide in Food: Update - Scientific Issues, Uncertainties, and Research Strategies," Chicago, April 13, 2004. Available at http://www.jifsan.umd.edu/acrylamide2004. htm.
21. Doerge, D. R., Young, J. F., McDaniel, L. P., Twaddle, N. C., and Churchwell, M. I. 2005a. Toxicokinetics of acrylamide and glycidamide in B6C3F(1) mice. Toxicol. Appl. Pharmacol. 202:258-267.
22. Doerge, D. R., Gamboa da Costa, G., McDaniel, L. P., Churchwell, M. I., Twaddle, N. C. and Beland, F. A. 2005b. DNA adducts derived from administration of acrylamide and glycidamide to mice and rats. Mutat. Res. 580:131-141.
23. Doerge, D. R., Young, J. F., McDaniel, L. P., Twaddle, N.C., Churchwell, M. I. 2005c. Toxicokinetics of acrylamide and glycidamine in Fischer 344 rats. Toxicol. Appl. Pharmacol. 208:199-209.
24. Dorne, J. L. C. M., Walton, K., and Renwick, A. G. 2001. Uncertainty factors for chemical risk assessment: human variability in the pharmacokinetics of CYP1A2 probe substrates. Food Chem. Toxicol. 39: 681-696.
25. Dybing, E., and Sanner, T. 2003. Risk assessment of acrylamide in foods. Toxicol Sci. 75:7-15.
26. Fennell, T. R., Snyder, R. W., Krol, W. L., and Sumner, S. C. J. 2003. Comparison of the hemoglobin adducts formed by administration of N-methylolacrylamide and acrylamide to rats. Toxicol. Sci. 71: 164-175.
27. Fennell, T., Snyder, R., Burgess, J. P., and Friedman, M. A. 2004. Metabolism and hemoglobin adducts of [1,2,3-13c3] acrylamide in humans. Abstract No. 845, Society of Toxicology meeting, Baltimore, March.
28. Fennell, T. R., Sumner, S. C., Snyder, R. W., Burgess, J., Spicer, R., Bridson, W. E., and Friedman, M. A. 2005. Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicol. Sci. 85:447-459.
29. Friedman, M. A., Dulak, L. H., and Stedham, M. A. 1995. A lifetime oncogenicity study in rats with acrylamide. Fundam. Appl. Toxicol. 27:95-105.
30. Gallagher, E. P., and Gardner, J. L. 2002. Comparative expression of two alpha class glutathione S-transferases in human adult and prenatal liver tissues. Biochem. Pharmacol. 63:2025-2036.
31. Generoso, W. M., Sega G. A., Lockhart, A. M., Hughes, L. A., Cain, K. T., Cacheiro, N. L., and Shelby, M. D. 1996. Dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide. Mutat. Res. 371:175-183.
32. Ghanayem, B. I., Witt, K. L., El-Hadri, L., Hoffler, U., Kissling, G. E., Shelby, M. D., and Bishop, J. B. 2005. Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: Evidence supporting a glycidamide-mediated effect. Biol. Reprod. 72:157-163.
33. Ginsberg, G. L., Pepelko, W. E., Goble, R. L., and Hattis, D. B. 1996. Comparison of contact site cancer potency across dose routes: Case study with epichlorohydrin. Risk Anal. 16:667-681.
34. Ginsberg, G., Smolenski, S., Hattis, D., and Sonawane, B. 2002. Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: Implications for risk assessment. Regul. Toxicol. Pharmacol. 38:297-309.
35. Ginsberg, G. 2003. Assessing cancer risks from short-term exposures in children. Risk Anal. 23:19-34.
36. Ginsberg, G., Smolenski, S., Neafsey, P., Hattis, D., and Walker, K. 2003. Genetic polymorphism database: Analysis of the influence of polymorphisms on inter-individual variability in xenobiotic metabolism. Report to the U.S. EPA Office of Research and Development. Washington, DC. Review draft.
37. Ginsberg, G., Hattis, D., and Sonawane, B. 2004a. Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants. Toxicol. Appl. Pharmacol. 198:164-183.
38. Ginsberg, G., Hattis, D., Russ, A., and Sonawane, B. 2004b. Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. J. Toxicol. Environ. Health A 67:297-329.
39. Hagmar, L., Wirfalt, E., Paulsson, B., and Tornqvist, M. 2005. Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender. Mutat. Res. 580:157-165.
40. Hashimoto, K., and Tanii, H. 1985. Mutagenicity of acrylamide and its analogues in Salmonella typhimurium. Mutat. Res. 158:129-133.
41. Hassett, C., Lin, J., Carty, C. L., Laurenzana, E. M., and Omiecinski, C. J. 1997. Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression. Arch. Biochem. Biophys. 337:275-283.
42. Hattis, D., and Shapiro, K. 1990 Analysis of dose/time/response relationships for chronic toxic effects - The case of acrylamide. NeuroToxicology 11:219-236.
43. Hattis, D., Goble, R., Russ, A., Chu, M., and Ericson, J. 2004. Age-related differences in susceptibility to carcinogenesis - A quantitative analysis of empirical animal bioassay data. Environ. Health Perspect. 112:1152-1158.
44. Hattis, D., Goble, R., and Chu, M. 2005. Age-related differences in susceptibility to carcinogenesis. II. Approaches for application and uncertainty analyses for individual genetically acing carcinogens. Environ. Health Perspect. 113:509-516.
45. Hiley, C., Fryer, A., Bell, J., Hume, R., and Strange, R. C. 1988. The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. Biochem. J. 254:255-259.
46. Holt, D. E., Hurley, R., and Harvey, D. 1995. Metabolism of chloramphenicol by glutathione S-transferase in human fetal and neonatal liver. Biol. Neonate 67:230-239.
47. International Commission on Radiological Protection. 1975. Report of the Task Force on the Reference Man. Oxford: Pergamon Press.
48. Johnson, K. A., Gorzinski, S. J., Bodner, K. M., Campbell, R. A., Wolf, C. H., Friedman, M. A., and Mast, R. W. 1986. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol. Appl. Pharmacol. 85:154-168.
49. Johnsrud, E. K., Koukouritaki, S. B., Divakaran, K., Brunengraber, L. L., Hines, R. N., and McCarver, D. G. 2003. Human hepatic CYP2E1 expression during development. J. Pharmacol. Exp. Ther. 307:402-407.
50. Kedderis, G. L., Teo, S. K., Batra, R., Held, S. D., and Gargas, M. L. 1996. Refinement and verification of the physiologically based dosimetry description for acrylonitrile in rats. Toxicol. Appl. Pharmacol. 140:422-435.
51. Kedderis, G. L. 1997. Extrapolation of in vitro enzyme induction data to humans in vivo. Chem. Biol. Interact. 107:109-121.
52. Kirman, C. R., Gargas, M. L., Deskin, R., Tonner-Navarro, L., and Andersen, M. E. 2003. A physiologically based pharmacokinetic model for acrylamide and its metabolite, glycidamide, in the rat. J. Toxicol. Environ. Health A 66:253-274.
53. Kohn, M.C., and Melnick, R. L. 2001. Physiological modeling of butadiene disposition in mice and rats. Chem. Biol. Interact. 135-136:285-301.
54. Konings, E. J. M., Baars, A. J., van Klaveren, J. D., Spanjer, M. C., Rensen, P. M., Hiemstra, M., van Kooij, J. A., and Peters, P. W. J. 2003. Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem. Toxicol. 41:1569-1579.
55. Kroetz, D. L., Kerr, B. M., McFarland, L. V., Loiseau, P., Wilensky, A. J., and Levy, R. H. (1993). Measurement of in vivo microsomal epoxide hydrolase activity in white subjects. Clin. Pharmacol. Ther. 53:306-315.
56. Kurata, N., Nishimura, Y., Iwase, M., Fischer, N. E., Tang, B. K., Inaba, T., and Yasuhara, H. 1998. Trimethadione metabolism by human liver cytochrome P450: Evidence for the involvement of CYP2E1. Xenobiotica 28:1041-1047.
57. Lambert, G. H., and Thorgeirsson, S. S. 1976. Glutathione in the developing mouse liver. I. Development curve and depletion after acetaminophen treatment. Biochem. Pharmacol. 25:1777-1781.
58. Lopachin, R. M., and Lehning, E. J. 1994. Acrylamide-induced distal axon degeneration: A proposed mechanism of action. NeuroToxicology 15:247-260.
59. Lucas, D., Menez, C., Girre, C., Berthou, F., Bodenez, P., Joannet, I., Hispard, E., Bardou, L., and Menez, J. 1995. Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics 5:298-304.
60. Mathew, J., Cattan, A. R., Hall, A. G., Hines, J. E., Nelson, R., Eastham, E., and Burt, A. D. 1992. Glutathione S-transferases in neonatal liver disease. J. Clin. Pathol. 45:679-683.
61. Meek, M. E., Renwick, A., Ohanian, E., Dourson, M., Lake, B., Naumann, B. D., and Vu, V. 2002. International Programme on Chemical Safety. Guidelines for application of chemical-specific adjustment factors in dose/concentration- response assessment. Toxicology 181-182:115-120.
62. Mera, N., Ohmori, S., Itahashi, K., Kiuchi, M., Igarashi, T., Rikihisa, T., and Kitada, M. 1994. Immunochemical evidence for the occurrence of Mu class glutathione S-transferase in human fetal livers. J. Biochem. (Tokyo) 116:315-320.
63. Miller, M. J., Carder, D. E., and Sipes, I. G. 1982. Pharmacokinetics of acrylamide in Fischer-344 rats. Toxicol. Appl. Pharmacol. 63:36-44.
64. Morel, F., Rauch, C., Coles, B., LeFerrec, E., and Guillouzo, A. (2002) The human glutathione transferase alpha locus: Genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. Pharmacogenetics 12:277-286.
65. Nakamura, H., Tanaka, E., Ishikawa, A., Fukao, K., Tsuji, K., and Ohkawa, H. 1998. Age-related changes in hepatic drug-oxidizing activity using trimethadione as a probe drug in humans. Hepatol. Res. 12:85-92.
66. National Resource Council. 1993. Pesticides in the diets of infants and children. Washington, DC: National Academy Press.
67. National Research Council. 2000. Scientific frontiers in developmental toxicology and risk assssment. Washington, DC: National Academy Press.
68. Nemeth, I., and Boda, D. 1994. Blood gluathione redox ratio as a parameter of oxidative stress in premature infants with IRDS. Free Radical Biol. Med. 16:347-353.
69. Omiecinski, C. J., Archer, L., and Swenson, L. 1994. Developmental expression of human microsomal epoxide hydrolase. J. Pharmacol. Exp. Ther. 269:417-423.
70. O'Shea, D., Davis, S., Kim, R., and Wilkinson, G. 1994. Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity. Clin.Pharmacol. Ther. 56:359-367.
71. Papp, A., Nemeth, I., Karg, E., and Papp, E. 1999. Glutathione status in retinopathy of prematurity. Free Radical Biol. Med. 27:738-743.
72. Paterson, S., and Mackay, D. 1989. Correlation of tissue, blood, and air partition coefficients of volatile organic chemicals. Br. J. Ind. Med. 46:321-328.
73. Paulsson, B., Rannug, A., Henderson, A.P., Golding, B. T., Tornqvist, M., and Warholm, M. 2005. In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. Mutat. Res. 580:53-59.
74. Pelekis, M., Gephart, L. A., and Lerman, S. E. 2001. Physiological-model- based derivation of the adult and child pharmacokinetic intraspecies uncertainty factors for volatile organic compounds. Regul. Toxicol. Pharmacol. 33:12-20.
75. Poulin, P., and Krishnan, K. 1995. A biologically-based algorithm for predicting blood:air partition coefficients of organic chemicals. Hum. Exp. Toxicol. 14:273-280.
76. Poulin, P., and Krishnan, K. 1996a. A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoblobin. Toxicol. Appl. Pharmacol. 136:131-137.
77. Poulin, P., and Krishnan, K. 1996b. A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals. Toxicol. Appl. Pharmacol. 136:126-130.
78. Price, K., Haddad, S., and Krishnan, K. 2003a. Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children. J. Toxicol. Environ. Health A 66:417-433.
79. Price, P. S., Conolly, R. B., Chaisson, C. F., Gross, E. A., Young, J. S., Mathis, E. T., Tedder, D. T. 2003b. Modeling inter-individual variation in physiological factors used in PBPK models of humans. Crit. Rev. Toxicol. 33:469-503.
80. Puppel, N., Tjaden, Z., Fueller, F., and Marko, D. 2005. DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells. Mutat. Res. 580:71-80.
81. Qanungo, S., and Mukherjea, M. 2000. Ontogenic profile of some antioxidants and lipid peroxidation in human placental and fetal tissues. Mol. Cell. Biochem. 215:11-19.
82. Raijmakers, M. T. M., Steegers E. A. P., and Peters W. H. M. 2001. Glutathione S-transferases and thiol concentrations in embryonic and early fetal tissues. Hum. Reprod. 16:2445-2450.
83. Ramsey, J., Young, J., and Gorzinski, S. 1984. Acrylamide: Toxicodynamics in rats. Midland, MI: Dow Chemical USA.
84. Ratanasavanh, D., Beaune, P., Morel, F., Flinois, J.-P., Guengerich, F. P., and Guillouzo, A. 1991. Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age. Hepatology 13:1142-1151.
85. Raymer, J. H., Sparacino, C. M., Velez, G. R., Padilla, S., MacPhail, R. C., and Crofton, K. M. 1993. Determination of acrylamide in rat serum and sciatic nerve by gas chromatography-electron-capture detection. J. Chromatogr. 619: 223-234.
86. Rees, D. C., and Hattis, D. 1994. Developing quantitative strategies for animal to human extrapolation. In Principles and methods of toxicology, 3rd ed., ed. A. W. Hayes, pp. 275- 315. New York: Raven Press.
87. Renwick, A., Dorne, J. L., and Walton, K. 2000. An analysis of the need for an additional uncertainty factor for infants and children. Regul. Toxicol Pharmacol. 31:286-296.
88. Rollins, D., Larsson, A., Steen, B., Krishnaswamy, K., Hagenfeldt, L., Moldeus, P., and Rane, A. 1981. Glutathione and gamma-glutamyl cycle enzymes in human fetal liver. J. Pharmacol. Exp. Ther. 217:697-700.
89. Sorgel, F., Weissenbacher, R., Kinzig-Schippers, M., Holman, A., Illauer, M., Skott, A., and Landersdorfer, C. 2002. Acrylamide: Increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans. Chemotherapy 48:267-274.
90. Sprenger, R., Schlagenhaufer, R., Kerb, R., Bruhn, C., Brockmoller, J., Roots, I., and Brinkmann, U. 2000. Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. Pharmacogenetics 10:557-565.
91. Strange, R. C., Davis, B. A., Faulder, C. G., Cotton, W., Bain, A. D., Hopkinson, D. A., and Hume, R. 1985. The human glutathione S-transferases: Developmental aspects of the GST1, GST2, and GST3 loci. Biochem. Genet. 23:1011-1028.
92. Strange, R. C., Howie, A. F., Hume, R., Matharoo, B., Bell, J., Hiley, C., Jones, P., and Beckett, G. J. 1989. The developmental expression of alpha-, mu- and pi-class glutathione S-tranferases in human liver. Biochem. Biophys. Acta 993:186-190.
93. Sumner, S. C., Williams, C. C., Snyder, R. W., Krol, W. L., Asgharian, B., and Fennel, T. R. 2003. Acrylamide: A comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure. Toxicol. Sci. 75:260-270.
94. 13C]acrylamide in rats and mice using 13C nuclear magnetic resonance spectroscopy. Chem. Res. Toxicol. 5:81-89.
95. Sweeney, L., Schlosser, P. M., Medinsky, M. A., and Bond, J. A. 1997. Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2-epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats. Carcinogenesis 18:611-625.
96. Tanaka, E., Terada, M., and Misawa, S. 2000. Cytochrome P450 2E1: Its clinical and toxicological role. J. Clin. Pharmacol. Ther. 25:165-175.
97. Tareke, E., Rydberg, P., Karlsson, P., Eriksson, S., and Tornqvist, M. 2002. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J. Agric. Food Chem. 50:4998-5006.
98. Tong, G. C., Cornwell, W. K., and Means, G. E. 2004. Reactions of acrylamide with glutathione and serum albumin. Toxicol. Lett. 147:127-131.
99. Treluyer, J. M., Cheron, G., Sonnier, M., and Cresteil, T. 1996. Cytochrome P-450 expression in sudden infant death syndrome. Biochem. Pharmacol. 52:497-504.
100. U.S. Environmental Protection Agency. 2005. Supplemental guidance for assessing susceptibility from early life exposure to carcinogens. EPA/630/R-03/003F. Available at http://www.epa.gov/cancerguidelines.
101. Vieira, I., Sonnier, M., and Crestiel, T. 1996. Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. Eur. J. Biochem. 238:476-483.
102. Walker, K., Hattis, D., Russ, A., and Ginsberg, G. 2004. Physiologically-based toxicokinetic modeling for acrylamide - Risk implications of polymorphisms and developmental changes in selected metabolic enzymes. Report from the George Perkins Marsh Institute, Clark University, and the Connecticut Department of Public Health to the U. S. Environmental Protection Agency under Cooperative Agreement 827195-0, December.
103. Wormhoudt, L., Commandeur, J., and Vermeulen, N. 1999. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity. Crit. Rev. Toxicol. 29:59-124.