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Volumn 28, Issue 11, 1998, Pages 1041-1047

Trimethadione metabolism by human liver cytochrome P450: Evidence for the involvement of CYP2E1

Author keywords

[No Author keywords available]

Indexed keywords

CHLORZOXAZONE; CYTOCHROME P450; DIMETHADIONE; DIMETHYLNITROSAMINE; FLUCONAZOLE; LIVER ENZYME; MEPHENYTOIN; PARACETAMOL; PHENACETIN; QUINIDINE; TOLBUTAMIDE; TRIMETHADIONE;

EID: 7844237876     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982598238930     Document Type: Article
Times cited : (21)

References (15)
  • 1
    • 0343892023 scopus 로고
    • Determination of trimethadione and metharbital by rat liver microsomal enzymes: Substrate concentration-yield relationships and competition between substrates
    • BUTLER, T. C. and POOLE, D. T., 1965, Determination of trimethadione and metharbital by rat liver microsomal enzymes: substrate concentration-yield relationships and competition between substrates. Biochemical Pharmacology, 14, 937-942.
    • (1965) Biochemical Pharmacology , vol.14 , pp. 937-942
    • Butler, T.C.1    Poole, D.T.2
  • 2
    • 0027996327 scopus 로고
    • Terfenadine metabolism in human liver: In vitro inhibition by macrolide antibiotics and azole antifungals
    • JURIMA-ROMET, M., CRAWFORD, K., CYR, T. and INAB, T., 1994, Terfenadine metabolism in human liver: in vitro inhibition by macrolide antibiotics and azole antifungals. Drug Metabolism and Disposition, 22, 849-857.
    • (1994) Drug Metabolism and Disposition , vol.22 , pp. 849-857
    • Jurima-Romet, M.1    Crawford, K.2    Cyr, T.3    Inab, T.4
  • 4
    • 0021142501 scopus 로고
    • A method for estimation of hepatic drug-metabolizing capacity; determination of concentration of trimethadione and its metabolite in human serum
    • KOBAYASHI, S., TANAKA, E., OGUCHI, K., YOSHIDA, T., KUROIWA, Y. and YASUHARA, H., 1984, A method for estimation of hepatic drug-metabolizing capacity; determination of concentration of trimethadione and its metabolite in human serum. Journal of Pharmaco-Bio Dynamics, 7, 329-335.
    • (1984) Journal of Pharmaco-Bio Dynamics , vol.7 , pp. 329-335
    • Kobayashi, S.1    Tanaka, E.2    Oguchi, K.3    Yoshida, T.4    Kuroiwa, Y.5    Yasuhara, H.6
  • 5
    • 0028052944 scopus 로고
    • Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity
    • NAKAMURA, M., TANAKA, E., MISAWA, S., SHIMADA, T., IMAOKA, S. and FUNAE, Y., 1994, Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity. Biochemical Pharmacology, 47, 247-251.
    • (1994) Biochemical Pharmacology , vol.47 , pp. 247-251
    • Nakamura, M.1    Tanaka, E.2    Misawa, S.3    Shimada, T.4    Imaoka, S.5    Funae, Y.6
  • 6
    • 7844236023 scopus 로고
    • The effects of inducers of different types of cytochrome P450 isozymes on serum dimethadione/trimethadione ratio in rats
    • NISHIMURA, Y., KOBAYASHI, S., KURATA, N., UCHIDA, E. and YASUHARA, H., 1992, The effects of inducers of different types of cytochrome P450 isozymes on serum dimethadione/trimethadione ratio in rats. Showa University Journal of Medical Sciences, 4, 7-14.
    • (1992) Showa University Journal of Medical Sciences , vol.4 , pp. 7-14
    • Nishimura, Y.1    Kobayashi, S.2    Kurata, N.3    Uchida, E.4    Yasuhara, H.5
  • 7
    • 0028986144 scopus 로고
    • The effects of inhibitors and substrates of different types of cytochrome P450 isozymes on serum dimethadione/ trimethadione ratio in rats in vivo
    • NISHIMURA, Y., KURATA, N., KOBAYASHI, S., UCHIDA, E. and YASUHARA, H., 1995, The effects of inhibitors and substrates of different types of cytochrome P450 isozymes on serum dimethadione/ trimethadione ratio in rats in vivo. Research Communications in Chemical Pathology and Pharmacology, 87, 145-154.
    • (1995) Research Communications in Chemical Pathology and Pharmacology , vol.87 , pp. 145-154
    • Nishimura, Y.1    Kurata, N.2    Kobayashi, S.3    Uchida, E.4    Yasuhara, H.5
  • 11
    • 0022402354 scopus 로고
    • The effect of indomethacin on hepatic drug-oxidizing capacity in the rat: Trimethadione and antipyrine metabolism as an indicator
    • TANAKA, E., KOBAYASHI, S., ARAMPHONGPHAN, A., KURATA, N., OGUCHI, K., KUROIWA, Y. and YASUHARA, H., 1985a, The effect of indomethacin on hepatic drug-oxidizing capacity in the rat: trimethadione and antipyrine metabolism as an indicator. Journal of Pharmaco-Bio Dynamics, 8, 773-779.
    • (1985) Journal of Pharmaco-Bio Dynamics , vol.8 , pp. 773-779
    • Tanaka, E.1    Kobayashi, S.2    Aramphongphan, A.3    Kurata, N.4    Oguchi, K.5    Kuroiwa, Y.6    Yasuhara, H.7
  • 12
    • 0024449432 scopus 로고
    • Simplified approach for determination of hepatic drug-oxidizing capacity using trimethadione metabolism as an indicator
    • TANAKA, E., KOBAYASHI, S., NAKAMURA, K., UCHIDA, E. and YASUHARA, H., 1989, Simplified approach for determination of hepatic drug-oxidizing capacity using trimethadione metabolism as an indicator. Biopharmaceutics and Drug Disposition, 10, 617-620.
    • (1989) Biopharmaceutics and Drug Disposition , vol.10 , pp. 617-620
    • Tanaka, E.1    Kobayashi, S.2    Nakamura, K.3    Uchida, E.4    Yasuhara, H.5
  • 15
    • 0022350942 scopus 로고
    • Effects of cimetidine and diethylaminoethyl 2,2-diphenylvalerate HCL(SKF525-A) on trimethadione metabolism in the rat
    • TANAKA, E., MISAWA, S. and KUROIWA, Y., 1985c, Effects of cimetidine and diethylaminoethyl 2,2-diphenylvalerate HCL(SKF525-A) on trimethadione metabolism in the rat. Journal of Pharmaco-Bio Dynamics, 8, 767-772.
    • (1985) Journal of Pharmaco-Bio Dynamics , vol.8 , pp. 767-772
    • Tanaka, E.1    Misawa, S.2    Kuroiwa, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.