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Volumn 81, Issue 6, 2007, Pages 1232-1250

High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOX P 2; UNCLASSIFIED DRUG;

EID: 36749013035     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/522238     Document Type: Article
Times cited : (202)

References (67)
  • 1
    • 85031447174 scopus 로고    scopus 로고
    • CGAP
    • CGAP, http://cgap.nci.nih.gov/
  • 2
    • 85031438298 scopus 로고    scopus 로고
    • DAVID
    • DAVID, http://niaid.abcc.ncifcrf.gov/
  • 3
    • 85031447912 scopus 로고    scopus 로고
    • FUZZNUC
    • FUZZNUC, http://bioweb.pasteur.fr/seqanal/interfaces/fuzznuc.html
  • 5
    • 85031449516 scopus 로고    scopus 로고
    • Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/ Omim/ (for FOXP2, developmental verbal dyspraxia, and Silver-Russell syndrome)
    • Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/ Omim/ (for FOXP2, developmental verbal dyspraxia, and Silver-Russell syndrome)
  • 6
    • 85031438966 scopus 로고    scopus 로고
    • WebGestalt, http://bioinfo.vanderbilt.edu/webgestalt/
    • WebGestalt
  • 7
    • 0038571125 scopus 로고    scopus 로고
    • Deciphering the genetic basis of speech and language disorders
    • Fisher SE, Lai CS, Monaco AP (2003) Deciphering the genetic basis of speech and language disorders. Annu Rev Neurosci 26:57-80
    • (2003) Annu Rev Neurosci , vol.26 , pp. 57-80
    • Fisher, S.E.1    Lai, C.S.2    Monaco, A.P.3
  • 9
    • 0035807360 scopus 로고    scopus 로고
    • A forkhead-domain gene is mutated in a severe speech and language disorder
    • Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP (2001) A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413:519-523
    • (2001) Nature , vol.413 , pp. 519-523
    • Lai, C.S.1    Fisher, S.E.2    Hurst, J.A.3    Vargha-Khadem, F.4    Monaco, A.P.5
  • 11
    • 0036190947 scopus 로고    scopus 로고
    • Behavioural analysis of an inherited speech and language disorder: Comparison with acquired aphasia
    • Watkins KE, Dronkers NF, Vargha-Khadem F (2002) Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia. Brain 125:452-464
    • (2002) Brain , vol.125 , pp. 452-464
    • Watkins, K.E.1    Dronkers, N.F.2    Vargha-Khadem, F.3
  • 15
    • 0036387193 scopus 로고    scopus 로고
    • Forkhead transcription factors: Key players in development and metabolism
    • Carlsson P, Mahlapuu M (2002) Forkhead transcription factors: key players in development and metabolism. Dev Biol 250:1-23
    • (2002) Dev Biol , vol.250 , pp. 1-23
    • Carlsson, P.1    Mahlapuu, M.2
  • 17
    • 16644382513 scopus 로고    scopus 로고
    • Human FOX gene family (review)
    • Katoh M, Katoh M (2004) Human FOX gene family (review). Int J Oncol 25:1495-1500
    • (2004) Int J Oncol , vol.25 , pp. 1495-1500
    • Katoh, M.1    Katoh, M.2
  • 19
    • 0030722976 scopus 로고    scopus 로고
    • Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body
    • Wehr R, Mansouri A, de Maeyer T, Gruss P (1997) Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body. Development 124:4447-4456
    • (1997) Development , vol.124 , pp. 4447-4456
    • Wehr, R.1    Mansouri, A.2    de Maeyer, T.3    Gruss, P.4
  • 20
    • 0042591396 scopus 로고    scopus 로고
    • Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors
    • Wang B, Lin D, Li C, Tucker P (2003) Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. J Biol Chem 278:24259-24268
    • (2003) J Biol Chem , vol.278 , pp. 24259-24268
    • Wang, B.1    Lin, D.2    Li, C.3    Tucker, P.4
  • 23
    • 0142153166 scopus 로고    scopus 로고
    • FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder
    • Lai CS, Gerrelli D, Monaco AP, Fisher SE, Copp AJ (2003) FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain 126:2455-2462
    • (2003) Brain , vol.126 , pp. 2455-2462
    • Lai, C.S.1    Gerrelli, D.2    Monaco, A.P.3    Fisher, S.E.4    Copp, A.J.5
  • 25
    • 29244467422 scopus 로고    scopus 로고
    • The eloquent ape: Genes, brains and the evolution of language
    • Fisher SE, Marcus GF (2006) The eloquent ape: genes, brains and the evolution of language. Nat Rev Genetics 7:9-20
    • (2006) Nat Rev Genetics , vol.7 , pp. 9-20
    • Fisher, S.E.1    Marcus, G.F.2
  • 26
    • 33646510364 scopus 로고    scopus 로고
    • Genome-wide analysis of protein-DNA interactions
    • Kim TH, Ren B (2006) Genome-wide analysis of protein-DNA interactions. Annu Rev Genomics Hum Genet 7:81-102
    • (2006) Annu Rev Genomics Hum Genet , vol.7 , pp. 81-102
    • Kim, T.H.1    Ren, B.2
  • 27
    • 36749050396 scopus 로고    scopus 로고
    • Spiteri E, Konopka G, Coppola G, Bomar J, Oldham M, Ou J, Vernes SC, Fisher SE, Ren B, Geschwind DH (2007) Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet 81:1144-1157 (in this issue)
    • Spiteri E, Konopka G, Coppola G, Bomar J, Oldham M, Ou J, Vernes SC, Fisher SE, Ren B, Geschwind DH (2007) Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet 81:1144-1157 (in this issue)
  • 28
    • 0348166011 scopus 로고    scopus 로고
    • Probing chromatin immunoprecipitates with CpG-island microarrays to identify genomic sites occupied by DNA-binding proteins
    • Oberley MJ, Farnham PJ (2003) Probing chromatin immunoprecipitates with CpG-island microarrays to identify genomic sites occupied by DNA-binding proteins. Methods Enzymol 371:577-596
    • (2003) Methods Enzymol , vol.371 , pp. 577-596
    • Oberley, M.J.1    Farnham, P.J.2
  • 30
    • 0242333835 scopus 로고    scopus 로고
    • Normalization of cDNA microarray data
    • Smyth GK, Speed T (2003) Normalization of cDNA microarray data. Methods 31:265-273
    • (2003) Methods , vol.31 , pp. 265-273
    • Smyth, G.K.1    Speed, T.2
  • 32
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 57:289-300
    • (1995) J R Stat Soc Ser B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 33
    • 2942550697 scopus 로고    scopus 로고
    • GOTree Machine (GOTM): A Web-based platform for interpreting sets of interesting genes using gene ontology hierarchies
    • Zhang B, Schmoyer D, Kirov S, Snoddy J (2004) GOTree Machine (GOTM): a Web-based platform for interpreting sets of interesting genes using gene ontology hierarchies. BMC Bioinformatics 5:16
    • (2004) BMC Bioinformatics , vol.5 , pp. 16
    • Zhang, B.1    Schmoyer, D.2    Kirov, S.3    Snoddy, J.4
  • 37
    • 0028353904 scopus 로고
    • The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix
    • Overdier DG, Porcella A, Costa RH (1994) The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. Mol Cell Biol 14:2755-2766
    • (1994) Mol Cell Biol , vol.14 , pp. 2755-2766
    • Overdier, D.G.1    Porcella, A.2    Costa, R.H.3
  • 38
    • 0028685490 scopus 로고
    • Fitting a mixture model by expectation maximization to discover motifs in biopolymers
    • Bailey TL, Elkan C (1994) Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc Int Conf Intell Syst Mol Biol 2:28-36
    • (1994) Proc Int Conf Intell Syst Mol Biol , vol.2 , pp. 28-36
    • Bailey, T.L.1    Elkan, C.2
  • 39
    • 0031877016 scopus 로고    scopus 로고
    • Combining evidence using pvalues: Application to sequence homology searches
    • Bailey TL, Gribskov M (1998) Combining evidence using pvalues: application to sequence homology searches. Bioinformatics 14:48-54
    • (1998) Bioinformatics , vol.14 , pp. 48-54
    • Bailey, T.L.1    Gribskov, M.2
  • 40
    • 85074914953 scopus 로고    scopus 로고
    • A PCR primer bank for quantitative gene expression analysis
    • Wang X, Seed B (2003) A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res 31:e154
    • (2003) Nucleic Acids Res , vol.31
    • Wang, X.1    Seed, B.2
  • 44
    • 0347986673 scopus 로고    scopus 로고
    • Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions
    • Li S, Weidenfeld J, Morrisey EE (2004) Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol 24:809-822
    • (2004) Mol Cell Biol , vol.24 , pp. 809-822
    • Li, S.1    Weidenfeld, J.2    Morrisey, E.E.3
  • 45
    • 0028293909 scopus 로고
    • Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro
    • Yoon JB, Li G, Roeder RG (1994) Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. Mol Cell Biol 14:1776-1785
    • (1994) Mol Cell Biol , vol.14 , pp. 1776-1785
    • Yoon, J.B.1    Li, G.2    Roeder, R.G.3
  • 47
    • 2542559015 scopus 로고    scopus 로고
    • Wnt genes define distinct boundaries in the developing human brain: Implications for human forebrain patterning
    • Abu-Khalil A, Fu L, Grove EA, Zecevic N, Geschwind DH (2004) Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. J Comp Neurol 474:276-288
    • (2004) J Comp Neurol , vol.474 , pp. 276-288
    • Abu-Khalil, A.1    Fu, L.2    Grove, E.A.3    Zecevic, N.4    Geschwind, D.H.5
  • 48
    • 33750391166 scopus 로고    scopus 로고
    • Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway
    • Zhou CJ, Borello U, Rubenstein JL, Pleasure SJ (2006) Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience 142:1119-1131
    • (2006) Neuroscience , vol.142 , pp. 1119-1131
    • Zhou, C.J.1    Borello, U.2    Rubenstein, J.L.3    Pleasure, S.J.4
  • 49
    • 0027997502 scopus 로고
    • Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    • Urbanek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M (1994) Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79:901-912
    • (1994) Cell , vol.79 , pp. 901-912
    • Urbanek, P.1    Wang, Z.Q.2    Fetka, I.3    Wagner, E.F.4    Busslinger, M.5
  • 50
    • 0032516040 scopus 로고    scopus 로고
    • Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein
    • Rudolph D, Tafuri A, Gass P, Hammerling GJ, Arnold B, Schutz G (1998) Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci USA 95:4481-4486
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4481-4486
    • Rudolph, D.1    Tafuri, A.2    Gass, P.3    Hammerling, G.J.4    Arnold, B.5    Schutz, G.6
  • 51
    • 0037171782 scopus 로고    scopus 로고
    • Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB
    • Lonze BE, Riccio A, Cohen S, Ginty DD (2002) Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34:371-385
    • (2002) Neuron , vol.34 , pp. 371-385
    • Lonze, B.E.1    Riccio, A.2    Cohen, S.3    Ginty, D.D.4
  • 52
    • 0037171762 scopus 로고    scopus 로고
    • Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory
    • Pittenger C, Huang YY, Paletzki RF, Bourtchouladze R, Scanlin H, Vronskaya S, Kandel ER (2002) Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron 34:447-462
    • (2002) Neuron , vol.34 , pp. 447-462
    • Pittenger, C.1    Huang, Y.Y.2    Paletzki, R.F.3    Bourtchouladze, R.4    Scanlin, H.5    Vronskaya, S.6    Kandel, E.R.7
  • 53
    • 0141755155 scopus 로고    scopus 로고
    • NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system
    • Breslin MB, Zhu M, Lan MS (2003) NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. J Biol Chem 278:38991-38997
    • (2003) J Biol Chem , vol.278 , pp. 38991-38997
    • Breslin, M.B.1    Zhu, M.2    Lan, M.S.3
  • 56
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF (2001) Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem 276:37672-37679
    • (2001) J Biol Chem , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 57
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY (2007) Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445:936-940
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 58
    • 1842524183 scopus 로고    scopus 로고
    • The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2
    • Bird AJ, Blankman E, Stillman DJ, Eide DJ, Winge DR (2004) The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2. EMBO J 23:1123-1132
    • (2004) EMBO J , vol.23 , pp. 1123-1132
    • Bird, A.J.1    Blankman, E.2    Stillman, D.J.3    Eide, D.J.4    Winge, D.R.5
  • 59
    • 0034996711 scopus 로고    scopus 로고
    • Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast
    • Washburn BK, Esposito RE (2001) Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast. Mol Cell Biol 21:2057-2069
    • (2001) Mol Cell Biol , vol.21 , pp. 2057-2069
    • Washburn, B.K.1    Esposito, R.E.2
  • 60
    • 27944489086 scopus 로고    scopus 로고
    • An evolutionary perspective on FoxP2: Strictly for the birds?
    • Scharff C, Haesler S (2005) An evolutionary perspective on FoxP2: strictly for the birds? Curr Opin Neurobiol 15:694-703
    • (2005) Curr Opin Neurobiol , vol.15 , pp. 694-703
    • Scharff, C.1    Haesler, S.2
  • 61
    • 33749836933 scopus 로고    scopus 로고
    • Singing mice, songbirds, and more: Models for FOXP2 function and dysfunction in human speech and language
    • White SA, Fisher SE, Geschwind DH, Scharff C, Holy TE (2006) Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language. J Neurosci 26:10376-10379
    • (2006) J Neurosci , vol.26 , pp. 10376-10379
    • White, S.A.1    Fisher, S.E.2    Geschwind, D.H.3    Scharff, C.4    Holy, T.E.5
  • 62
    • 0037871862 scopus 로고    scopus 로고
    • Identifi-cation of a new member of type I Na/phosphate co-transporter in the rat kidney
    • Ishibashi K, Matsuzaki T, Takata K, Imai M (2003) Identifi-cation of a new member of type I Na/phosphate co-transporter in the rat kidney. Nephron Physiol 94:10-18
    • (2003) Nephron Physiol , vol.94 , pp. 10-18
    • Ishibashi, K.1    Matsuzaki, T.2    Takata, K.3    Imai, M.4
  • 63
    • 1242295189 scopus 로고    scopus 로고
    • Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
    • Reimer RJ, Edwards RH (2004) Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. Pflugers Arch 447:629-635
    • (2004) Pflugers Arch , vol.447 , pp. 629-635
    • Reimer, R.J.1    Edwards, R.H.2
  • 64
    • 0034802109 scopus 로고    scopus 로고
    • The Cancer Genome Anatomy Project: New resources for reading the molecular signatures of cancer
    • Strausberg RL (2001) The Cancer Genome Anatomy Project: new resources for reading the molecular signatures of cancer. J Pathol 195:31-40
    • (2001) J Pathol , vol.195 , pp. 31-40
    • Strausberg, R.L.1
  • 65
    • 33646805064 scopus 로고    scopus 로고
    • T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects
    • Beima KM, Miazgowicz MM, Lewis MD, Yan PS, Huang TH, Weinmann AS (2006) T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem 281:11992-12000
    • (2006) J Biol Chem , vol.281 , pp. 11992-12000
    • Beima, K.M.1    Miazgowicz, M.M.2    Lewis, M.D.3    Yan, P.S.4    Huang, T.H.5    Weinmann, A.S.6
  • 67
    • 0036959262 scopus 로고    scopus 로고
    • Accelerated protein evolution and origins of human-specific features: Foxp2 as an example
    • Zhang J, Webb DM, Podlaha O (2002) Accelerated protein evolution and origins of human-specific features: Foxp2 as an example. Genetics 162:1825-1835
    • (2002) Genetics , vol.162 , pp. 1825-1835
    • Zhang, J.1    Webb, D.M.2    Podlaha, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.